Abstract
| Original language | English |
|---|---|
| Journal | European Journal of Nutrition |
| DOIs | |
| Publication status | Published - 2019 |
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B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study. / Oliai Araghi, Sadaf; Braun, Kim V. E.; van der Velde, Nathalie; van Dijk, Suzanne C.; van Schoor, Natasja M.; Zillikens, M. Carola; de Groot, Lisette C. P. G. M.; Uitterlinden, Andre G.; Stricker, Bruno H.; Voortman, Trudy; Kiefte-de Jong, Jessica C.
In: European Journal of Nutrition, 2019.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study
AU - Oliai Araghi, Sadaf
AU - Braun, Kim V. E.
AU - van der Velde, Nathalie
AU - van Dijk, Suzanne C.
AU - van Schoor, Natasja M.
AU - Zillikens, M. Carola
AU - de Groot, Lisette C. P. G. M.
AU - Uitterlinden, Andre G.
AU - Stricker, Bruno H.
AU - Voortman, Trudy
AU - Kiefte-de Jong, Jessica C.
PY - 2019
Y1 - 2019
N2 - Purpose: Higher folate and vitamin-B12 have been linked to lower risk of overweight. However, whether this is a causal effect of these B-vitamins on obesity risk remains unclear and evidence in older individuals is scarce. This study aimed to assess the role of B-vitamin supplementation and levels on body composition in older individuals. Methods: A double-blind, randomized controlled trial in 2919 participants aged ≥ 65 years with elevated homocysteine levels. The intervention comprised a 2-year supplementation with a combination of folic acid (400 µg) and vitamin B12 (500 µg), or with placebo. Serum folate, vitamin-B12, active vitamin-B12 (HoloTC), methylmalonic acid (MMA), and anthropometrics were measured at baseline and after 2 years of follow-up. Dietary intake of folate and vitamin-B12 was measured at baseline in a subsample (n = 603) using a validated food-frequency questionnaire. Fat mass index (FMI) and fat-free mass index (FFMI) were assessed with Dual Energy X-ray absorptiometry (DXA). Results: Cross-sectional analyses showed that a 1 nmol/L higher serum folate was associated with a 0.021 kg/m 2 lower BMI (95% CI − 0.039; − 0.004). Higher HoloTC (per pmol/L log-transformed) was associated with a 0.955 kg/m 2 higher FMI (95% CI 0.262; 1.647), and higher MMA (per μgmol/L) was associated with a 1.108 kg/m 2 lower FMI (95% CI − 1.899; − 0.316). However, random allocation of B-vitamins did not have a significant effect on changes in BMI, FMI or FFMI during 2 years of intervention. Conclusions: Although observational data suggested that folate and vitamin B12 status are associated with body composition, random allocation of a supplement with both B-vitamins combined versus placebo did not confirm an effect on BMI or body composition.
AB - Purpose: Higher folate and vitamin-B12 have been linked to lower risk of overweight. However, whether this is a causal effect of these B-vitamins on obesity risk remains unclear and evidence in older individuals is scarce. This study aimed to assess the role of B-vitamin supplementation and levels on body composition in older individuals. Methods: A double-blind, randomized controlled trial in 2919 participants aged ≥ 65 years with elevated homocysteine levels. The intervention comprised a 2-year supplementation with a combination of folic acid (400 µg) and vitamin B12 (500 µg), or with placebo. Serum folate, vitamin-B12, active vitamin-B12 (HoloTC), methylmalonic acid (MMA), and anthropometrics were measured at baseline and after 2 years of follow-up. Dietary intake of folate and vitamin-B12 was measured at baseline in a subsample (n = 603) using a validated food-frequency questionnaire. Fat mass index (FMI) and fat-free mass index (FFMI) were assessed with Dual Energy X-ray absorptiometry (DXA). Results: Cross-sectional analyses showed that a 1 nmol/L higher serum folate was associated with a 0.021 kg/m 2 lower BMI (95% CI − 0.039; − 0.004). Higher HoloTC (per pmol/L log-transformed) was associated with a 0.955 kg/m 2 higher FMI (95% CI 0.262; 1.647), and higher MMA (per μgmol/L) was associated with a 1.108 kg/m 2 lower FMI (95% CI − 1.899; − 0.316). However, random allocation of B-vitamins did not have a significant effect on changes in BMI, FMI or FFMI during 2 years of intervention. Conclusions: Although observational data suggested that folate and vitamin B12 status are associated with body composition, random allocation of a supplement with both B-vitamins combined versus placebo did not confirm an effect on BMI or body composition.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85065739249&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31076856
U2 - 10.1007/s00394-019-01985-8
DO - 10.1007/s00394-019-01985-8
M3 - Article
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
ER -