Baseline autonomic nervous system activity in female children and adolescents with conduct disorder: Psychophysiological findings from the FemNAT-CD study

Helena Oldenhof, Martin Prätzlich, Katharina Ackermann, Rosalind Baker, Molly Batchelor, Sarah Baumann, Anka Bernhard, Roberta Clanton, Dimitris Dikeos, Roberta Dochnal, Lynn Valérie Fehlbaum, Aranzazu Fernández-Rivas, Eco de Geus, Karen Gonzalez, Maider González de Artaza-Lavesa, Silvina Guijarro, Malou Gundlach, Beate Herpertz-Dahlmann, Amaia Hervas, Lucres Jansen & 20 others Linda Kersten, Gregor Kohls, Angeliki Konsta, Helen Lazaratou, I. aki Kerexeta-Lizeaga, Anne Martinelli, Tisse van Nimwegen, Ignazio Puzzo, Nora Maria Raschle, Jack Rogers, R. ka Siklósi, Areti Smaragdi, Martin Steppan, Stephane de Brito, Graeme Fairchild, Meinhard Kieser, Kerstin Konrad, Christine Freitag, Christina Stadler, Arne Popma

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: Autonomic nervous system (ANS) functioning has been widely studied in relation to antisocial behavior, such as Conduct Disorder (CD). However, research in females is scarce and findings are inconsistent. This study investigated baseline ANS activity in CD children and adolescents and tested for sex differences. Furthermore, subgroups of CD were investigated: +/‐ Limited Prosocial Emotions (LPE), +/‐ comorbid internalizing disorders (INT). Methods: Baseline ANS activity was measured by Heart Rate (HR), Heart Rate Variability (HRV; parasympathetic activity), Pre-Ejection Period (PEP; sympathetic activity), and Respiration Rate (RR). 659 females (296 CD, 363 controls) and 351 males (187 CD, 164 controls), aged 9–18 years participated. Results: Baseline HR, HRV and PEP did not differ between CD subjects and controls in both sexes. RR was higher in CD participants than controls amongst females, but not males. LPE was unrelated to ANS activity, whereas females with CD + INT presented lower HRV. Conclusions: These results suggest that baseline ANS activity is not a robust indicator for CD. However, deviant ANS activity – especially parasympathetic activity - was observed in CD females with internalizing comorbidity. The psychophysiological abnormalities observed in this subgroup are indicative of emotion regulation problems. Accordingly, this subgroup may require specific interventions.
Original languageEnglish
JournalJournal of Criminal Justice
DOIs
Publication statusE-pub ahead of print - 2018

Cite this

Oldenhof, Helena ; Prätzlich, Martin ; Ackermann, Katharina ; Baker, Rosalind ; Batchelor, Molly ; Baumann, Sarah ; Bernhard, Anka ; Clanton, Roberta ; Dikeos, Dimitris ; Dochnal, Roberta ; Fehlbaum, Lynn Valérie ; Fernández-Rivas, Aranzazu ; de Geus, Eco ; Gonzalez, Karen ; de Artaza-Lavesa, Maider González ; Guijarro, Silvina ; Gundlach, Malou ; Herpertz-Dahlmann, Beate ; Hervas, Amaia ; Jansen, Lucres ; Kersten, Linda ; Kohls, Gregor ; Konsta, Angeliki ; Lazaratou, Helen ; Kerexeta-Lizeaga, I. aki ; Martinelli, Anne ; van Nimwegen, Tisse ; Puzzo, Ignazio ; Raschle, Nora Maria ; Rogers, Jack ; Siklósi, R. ka ; Smaragdi, Areti ; Steppan, Martin ; de Brito, Stephane ; Fairchild, Graeme ; Kieser, Meinhard ; Konrad, Kerstin ; Freitag, Christine ; Stadler, Christina ; Popma, Arne. / Baseline autonomic nervous system activity in female children and adolescents with conduct disorder: Psychophysiological findings from the FemNAT-CD study. In: Journal of Criminal Justice. 2018.
@article{9587a3183d064807a22a5c941739f8d5,
title = "Baseline autonomic nervous system activity in female children and adolescents with conduct disorder: Psychophysiological findings from the FemNAT-CD study",
abstract = "Purpose: Autonomic nervous system (ANS) functioning has been widely studied in relation to antisocial behavior, such as Conduct Disorder (CD). However, research in females is scarce and findings are inconsistent. This study investigated baseline ANS activity in CD children and adolescents and tested for sex differences. Furthermore, subgroups of CD were investigated: +/‐ Limited Prosocial Emotions (LPE), +/‐ comorbid internalizing disorders (INT). Methods: Baseline ANS activity was measured by Heart Rate (HR), Heart Rate Variability (HRV; parasympathetic activity), Pre-Ejection Period (PEP; sympathetic activity), and Respiration Rate (RR). 659 females (296 CD, 363 controls) and 351 males (187 CD, 164 controls), aged 9–18 years participated. Results: Baseline HR, HRV and PEP did not differ between CD subjects and controls in both sexes. RR was higher in CD participants than controls amongst females, but not males. LPE was unrelated to ANS activity, whereas females with CD + INT presented lower HRV. Conclusions: These results suggest that baseline ANS activity is not a robust indicator for CD. However, deviant ANS activity – especially parasympathetic activity - was observed in CD females with internalizing comorbidity. The psychophysiological abnormalities observed in this subgroup are indicative of emotion regulation problems. Accordingly, this subgroup may require specific interventions.",
author = "Helena Oldenhof and Martin Pr{\"a}tzlich and Katharina Ackermann and Rosalind Baker and Molly Batchelor and Sarah Baumann and Anka Bernhard and Roberta Clanton and Dimitris Dikeos and Roberta Dochnal and Fehlbaum, {Lynn Val{\'e}rie} and Aranzazu Fern{\'a}ndez-Rivas and {de Geus}, Eco and Karen Gonzalez and {de Artaza-Lavesa}, {Maider Gonz{\'a}lez} and Silvina Guijarro and Malou Gundlach and Beate Herpertz-Dahlmann and Amaia Hervas and Lucres Jansen and Linda Kersten and Gregor Kohls and Angeliki Konsta and Helen Lazaratou and Kerexeta-Lizeaga, {I. aki} and Anne Martinelli and {van Nimwegen}, Tisse and Ignazio Puzzo and Raschle, {Nora Maria} and Jack Rogers and Sikl{\'o}si, {R. ka} and Areti Smaragdi and Martin Steppan and {de Brito}, Stephane and Graeme Fairchild and Meinhard Kieser and Kerstin Konrad and Christine Freitag and Christina Stadler and Arne Popma",
year = "2018",
doi = "10.1016/j.jcrimjus.2018.05.011",
language = "English",
journal = "Journal of Criminal Justice",
issn = "0047-2352",
publisher = "Elsevier BV",

}

Oldenhof, H, Prätzlich, M, Ackermann, K, Baker, R, Batchelor, M, Baumann, S, Bernhard, A, Clanton, R, Dikeos, D, Dochnal, R, Fehlbaum, LV, Fernández-Rivas, A, de Geus, E, Gonzalez, K, de Artaza-Lavesa, MG, Guijarro, S, Gundlach, M, Herpertz-Dahlmann, B, Hervas, A, Jansen, L, Kersten, L, Kohls, G, Konsta, A, Lazaratou, H, Kerexeta-Lizeaga, IA, Martinelli, A, van Nimwegen, T, Puzzo, I, Raschle, NM, Rogers, J, Siklósi, RK, Smaragdi, A, Steppan, M, de Brito, S, Fairchild, G, Kieser, M, Konrad, K, Freitag, C, Stadler, C & Popma, A 2018, 'Baseline autonomic nervous system activity in female children and adolescents with conduct disorder: Psychophysiological findings from the FemNAT-CD study' Journal of Criminal Justice. https://doi.org/10.1016/j.jcrimjus.2018.05.011

Baseline autonomic nervous system activity in female children and adolescents with conduct disorder: Psychophysiological findings from the FemNAT-CD study. / Oldenhof, Helena; Prätzlich, Martin; Ackermann, Katharina; Baker, Rosalind; Batchelor, Molly; Baumann, Sarah; Bernhard, Anka; Clanton, Roberta; Dikeos, Dimitris; Dochnal, Roberta; Fehlbaum, Lynn Valérie; Fernández-Rivas, Aranzazu; de Geus, Eco; Gonzalez, Karen; de Artaza-Lavesa, Maider González; Guijarro, Silvina; Gundlach, Malou; Herpertz-Dahlmann, Beate; Hervas, Amaia; Jansen, Lucres; Kersten, Linda; Kohls, Gregor; Konsta, Angeliki; Lazaratou, Helen; Kerexeta-Lizeaga, I. aki; Martinelli, Anne; van Nimwegen, Tisse; Puzzo, Ignazio; Raschle, Nora Maria; Rogers, Jack; Siklósi, R. ka; Smaragdi, Areti; Steppan, Martin; de Brito, Stephane; Fairchild, Graeme; Kieser, Meinhard; Konrad, Kerstin; Freitag, Christine; Stadler, Christina; Popma, Arne.

In: Journal of Criminal Justice, 2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Baseline autonomic nervous system activity in female children and adolescents with conduct disorder: Psychophysiological findings from the FemNAT-CD study

AU - Oldenhof, Helena

AU - Prätzlich, Martin

AU - Ackermann, Katharina

AU - Baker, Rosalind

AU - Batchelor, Molly

AU - Baumann, Sarah

AU - Bernhard, Anka

AU - Clanton, Roberta

AU - Dikeos, Dimitris

AU - Dochnal, Roberta

AU - Fehlbaum, Lynn Valérie

AU - Fernández-Rivas, Aranzazu

AU - de Geus, Eco

AU - Gonzalez, Karen

AU - de Artaza-Lavesa, Maider González

AU - Guijarro, Silvina

AU - Gundlach, Malou

AU - Herpertz-Dahlmann, Beate

AU - Hervas, Amaia

AU - Jansen, Lucres

AU - Kersten, Linda

AU - Kohls, Gregor

AU - Konsta, Angeliki

AU - Lazaratou, Helen

AU - Kerexeta-Lizeaga, I. aki

AU - Martinelli, Anne

AU - van Nimwegen, Tisse

AU - Puzzo, Ignazio

AU - Raschle, Nora Maria

AU - Rogers, Jack

AU - Siklósi, R. ka

AU - Smaragdi, Areti

AU - Steppan, Martin

AU - de Brito, Stephane

AU - Fairchild, Graeme

AU - Kieser, Meinhard

AU - Konrad, Kerstin

AU - Freitag, Christine

AU - Stadler, Christina

AU - Popma, Arne

PY - 2018

Y1 - 2018

N2 - Purpose: Autonomic nervous system (ANS) functioning has been widely studied in relation to antisocial behavior, such as Conduct Disorder (CD). However, research in females is scarce and findings are inconsistent. This study investigated baseline ANS activity in CD children and adolescents and tested for sex differences. Furthermore, subgroups of CD were investigated: +/‐ Limited Prosocial Emotions (LPE), +/‐ comorbid internalizing disorders (INT). Methods: Baseline ANS activity was measured by Heart Rate (HR), Heart Rate Variability (HRV; parasympathetic activity), Pre-Ejection Period (PEP; sympathetic activity), and Respiration Rate (RR). 659 females (296 CD, 363 controls) and 351 males (187 CD, 164 controls), aged 9–18 years participated. Results: Baseline HR, HRV and PEP did not differ between CD subjects and controls in both sexes. RR was higher in CD participants than controls amongst females, but not males. LPE was unrelated to ANS activity, whereas females with CD + INT presented lower HRV. Conclusions: These results suggest that baseline ANS activity is not a robust indicator for CD. However, deviant ANS activity – especially parasympathetic activity - was observed in CD females with internalizing comorbidity. The psychophysiological abnormalities observed in this subgroup are indicative of emotion regulation problems. Accordingly, this subgroup may require specific interventions.

AB - Purpose: Autonomic nervous system (ANS) functioning has been widely studied in relation to antisocial behavior, such as Conduct Disorder (CD). However, research in females is scarce and findings are inconsistent. This study investigated baseline ANS activity in CD children and adolescents and tested for sex differences. Furthermore, subgroups of CD were investigated: +/‐ Limited Prosocial Emotions (LPE), +/‐ comorbid internalizing disorders (INT). Methods: Baseline ANS activity was measured by Heart Rate (HR), Heart Rate Variability (HRV; parasympathetic activity), Pre-Ejection Period (PEP; sympathetic activity), and Respiration Rate (RR). 659 females (296 CD, 363 controls) and 351 males (187 CD, 164 controls), aged 9–18 years participated. Results: Baseline HR, HRV and PEP did not differ between CD subjects and controls in both sexes. RR was higher in CD participants than controls amongst females, but not males. LPE was unrelated to ANS activity, whereas females with CD + INT presented lower HRV. Conclusions: These results suggest that baseline ANS activity is not a robust indicator for CD. However, deviant ANS activity – especially parasympathetic activity - was observed in CD females with internalizing comorbidity. The psychophysiological abnormalities observed in this subgroup are indicative of emotion regulation problems. Accordingly, this subgroup may require specific interventions.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047749308&origin=inward

U2 - 10.1016/j.jcrimjus.2018.05.011

DO - 10.1016/j.jcrimjus.2018.05.011

M3 - Article

JO - Journal of Criminal Justice

JF - Journal of Criminal Justice

SN - 0047-2352

ER -