TY - JOUR
T1 - BclI glucocorticoid receptor polymorphism in relation to arterial stiffening and cardiac structure and function
T2 - The hoorn and codam studies
AU - Van Moorsel, DIrk
AU - Henry, Ronald M.
AU - Schaper, Nicolaas C.
AU - Van Greevenbroek, Marleen M.
AU - Van Rossum, Elisabeth F.
AU - Hart, Leen M.
AU - Schalkwijk, Casper G.
AU - Van Der Kallen, Carla J.
AU - Dekker, Jacqueline M.
AU - Stehouwer, Coen D.
AU - Havekes, Bas
PY - 2017
Y1 - 2017
N2 - BACKGROUND Chronic glucocorticoid excess is associated with arterial stiffening and cardiac dysfunction. The BclI glucocorticoid receptor (GR) polymorphism increases GR sensitivity and is associated with a higher body mass index (BMI) and some proxies for cardiovascular disease (CVD). Whether BclI influences arterial stiffening and cardiac dysfunction is currently unknown. Therefore, the aim of the present study was to investigate the association of the BclI polymorphism with arterial stiffening and cardiac structure and function. METHODS We conducted an observational cohort study, combining 2 cohort studies designed to investigate genetic and metabolic determinants of CVD. We genotyped 1,124 individuals (age: 64.7 ± 8.5 years) from the Hoorn study and Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study for BclI. Several arterial stiffening indices of the carotid (Hoorn and CODAM study), brachial and femoral artery and the carotid-femoral pulse wave velocity (Hoorn study only) were determined. In addition, in the Hoorn study, we determined several variables of cardiac structure and function. RESULTS We identified 155 homozygous carriers (GG), 498 heterozygous carriers (CG), and 471 noncarriers (CC) of the BclI polymorphism. BclI genotypes did not display significant differences in variables of arterial stiffening (e.g., carotid distensibility coefficient (DC): 12.41 ± 5.37 vs. 12.87 ± 5.55 10?3/kPa [mean ± SD]; P = 0.38; homozygous vs. noncarriers). In addition, no clear differences in estimates of cardiac structure and function were found. CONCLUSIONS Even though BclI is associated with a higher BMI and some proxies of CVD, our results do not support the concept that BclI carrier status is associated with greater arterial stiffening or cardiac dysfunction.
AB - BACKGROUND Chronic glucocorticoid excess is associated with arterial stiffening and cardiac dysfunction. The BclI glucocorticoid receptor (GR) polymorphism increases GR sensitivity and is associated with a higher body mass index (BMI) and some proxies for cardiovascular disease (CVD). Whether BclI influences arterial stiffening and cardiac dysfunction is currently unknown. Therefore, the aim of the present study was to investigate the association of the BclI polymorphism with arterial stiffening and cardiac structure and function. METHODS We conducted an observational cohort study, combining 2 cohort studies designed to investigate genetic and metabolic determinants of CVD. We genotyped 1,124 individuals (age: 64.7 ± 8.5 years) from the Hoorn study and Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study for BclI. Several arterial stiffening indices of the carotid (Hoorn and CODAM study), brachial and femoral artery and the carotid-femoral pulse wave velocity (Hoorn study only) were determined. In addition, in the Hoorn study, we determined several variables of cardiac structure and function. RESULTS We identified 155 homozygous carriers (GG), 498 heterozygous carriers (CG), and 471 noncarriers (CC) of the BclI polymorphism. BclI genotypes did not display significant differences in variables of arterial stiffening (e.g., carotid distensibility coefficient (DC): 12.41 ± 5.37 vs. 12.87 ± 5.55 10?3/kPa [mean ± SD]; P = 0.38; homozygous vs. noncarriers). In addition, no clear differences in estimates of cardiac structure and function were found. CONCLUSIONS Even though BclI is associated with a higher BMI and some proxies of CVD, our results do not support the concept that BclI carrier status is associated with greater arterial stiffening or cardiac dysfunction.
KW - Arterial stiffening
KW - Arterial stiffness
KW - BclI
KW - Blood pressure
KW - Cardiac function
KW - Cardiac structure
KW - Glucocorticoid receptor
KW - Glucocorticoid receptor polymorphism
KW - Glucocorticoids
KW - Hypertension
KW - Left ventricular function
KW - Rs41423247
UR - http://www.scopus.com/inward/record.url?scp=85016206025&partnerID=8YFLogxK
U2 - 10.1093/ajh/hpw196
DO - 10.1093/ajh/hpw196
M3 - Article
C2 - 28096152
AN - SCOPUS:85016206025
VL - 30
SP - 286
EP - 294
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 3
ER -