Should infective endocarditis be treated with oral antibiotics?

Research output: Contribution to journalArticleProfessional

Abstract

The recently published POET trial breaks with the established paradigm of long-term, high-dose intravenous antibiotics for all patients with endocarditis. The study involved 400 Danish patients who had endocarditis caused by Gram-positive micro-organisms and who had a favourable response to initial intravenous therapy. The IV to oral switch appeared to be non-inferior to continuing intravenous treatment. From the perspective of antibiotic stewardship, this is a step forward because a shorter period of intravenous therapy reduces catheter-associated complications. However, treating clinicians should realise that the study had strict inclusion criteria and that its results apply to selected, low-risk patients only.
Translated title of the contributionShould infective endocarditis be treated with oral antibiotics?
Original languageDutch
Article numberD3440
JournalNederlands Tijdschrift voor Geneeskunde
Volume163
Issue number15
Publication statusPublished - 1 Apr 2019

Cite this

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title = "Behandeling voor endocarditis afronden met orale antibiotica?",
abstract = "The recently published POET trial breaks with the established paradigm of long-term, high-dose intravenous antibiotics for all patients with endocarditis. The study involved 400 Danish patients who had endocarditis caused by Gram-positive micro-organisms and who had a favourable response to initial intravenous therapy. The IV to oral switch appeared to be non-inferior to continuing intravenous treatment. From the perspective of antibiotic stewardship, this is a step forward because a shorter period of intravenous therapy reduces catheter-associated complications. However, treating clinicians should realise that the study had strict inclusion criteria and that its results apply to selected, low-risk patients only.",
author = "Sigaloff, {Kim C. E.}",
year = "2019",
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language = "Dutch",
volume = "163",
journal = "Nederlands Tijdschrift voor Geneeskunde",
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Behandeling voor endocarditis afronden met orale antibiotica? / Sigaloff, Kim C. E.

In: Nederlands Tijdschrift voor Geneeskunde, Vol. 163, No. 15, D3440, 01.04.2019.

Research output: Contribution to journalArticleProfessional

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PY - 2019/4/1

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N2 - The recently published POET trial breaks with the established paradigm of long-term, high-dose intravenous antibiotics for all patients with endocarditis. The study involved 400 Danish patients who had endocarditis caused by Gram-positive micro-organisms and who had a favourable response to initial intravenous therapy. The IV to oral switch appeared to be non-inferior to continuing intravenous treatment. From the perspective of antibiotic stewardship, this is a step forward because a shorter period of intravenous therapy reduces catheter-associated complications. However, treating clinicians should realise that the study had strict inclusion criteria and that its results apply to selected, low-risk patients only.

AB - The recently published POET trial breaks with the established paradigm of long-term, high-dose intravenous antibiotics for all patients with endocarditis. The study involved 400 Danish patients who had endocarditis caused by Gram-positive micro-organisms and who had a favourable response to initial intravenous therapy. The IV to oral switch appeared to be non-inferior to continuing intravenous treatment. From the perspective of antibiotic stewardship, this is a step forward because a shorter period of intravenous therapy reduces catheter-associated complications. However, treating clinicians should realise that the study had strict inclusion criteria and that its results apply to selected, low-risk patients only.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/31050269

M3 - Article

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JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

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