Beta-adrenoceptor mediated inhibition of long-term reward-related memory reconsolidation

Leontien Diergaarde, Anton N M Schoffelmeer, Taco J De Vries

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Well-consolidated fear-related memories, once retrieved, are susceptible to disruption and require reconsolidation in order to be maintained. We examined whether reactivated reward-related memories are also susceptible to interference by evaluating the effect of propranolol (PROP), a beta-adrenergic antagonist known to impair reconsolidation of fear-related memories, on context-induced sucrose seeking. PROP administration upon reactivation reduced sucrose seeking behaviour 3 weeks post-training, indicating that reconsolidation of reward-related memories can be disrupted after a long post-training interval.

Original languageEnglish
Pages (from-to)333-6
Number of pages4
JournalBehavioural Brain Research
Volume170
Issue number2
DOIs
Publication statusPublished - 30 Jun 2006

Cite this

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title = "Beta-adrenoceptor mediated inhibition of long-term reward-related memory reconsolidation",
abstract = "Well-consolidated fear-related memories, once retrieved, are susceptible to disruption and require reconsolidation in order to be maintained. We examined whether reactivated reward-related memories are also susceptible to interference by evaluating the effect of propranolol (PROP), a beta-adrenergic antagonist known to impair reconsolidation of fear-related memories, on context-induced sucrose seeking. PROP administration upon reactivation reduced sucrose seeking behaviour 3 weeks post-training, indicating that reconsolidation of reward-related memories can be disrupted after a long post-training interval.",
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Beta-adrenoceptor mediated inhibition of long-term reward-related memory reconsolidation. / Diergaarde, Leontien; Schoffelmeer, Anton N M; De Vries, Taco J.

In: Behavioural Brain Research, Vol. 170, No. 2, 30.06.2006, p. 333-6.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Beta-adrenoceptor mediated inhibition of long-term reward-related memory reconsolidation

AU - Diergaarde, Leontien

AU - Schoffelmeer, Anton N M

AU - De Vries, Taco J

PY - 2006/6/30

Y1 - 2006/6/30

N2 - Well-consolidated fear-related memories, once retrieved, are susceptible to disruption and require reconsolidation in order to be maintained. We examined whether reactivated reward-related memories are also susceptible to interference by evaluating the effect of propranolol (PROP), a beta-adrenergic antagonist known to impair reconsolidation of fear-related memories, on context-induced sucrose seeking. PROP administration upon reactivation reduced sucrose seeking behaviour 3 weeks post-training, indicating that reconsolidation of reward-related memories can be disrupted after a long post-training interval.

AB - Well-consolidated fear-related memories, once retrieved, are susceptible to disruption and require reconsolidation in order to be maintained. We examined whether reactivated reward-related memories are also susceptible to interference by evaluating the effect of propranolol (PROP), a beta-adrenergic antagonist known to impair reconsolidation of fear-related memories, on context-induced sucrose seeking. PROP administration upon reactivation reduced sucrose seeking behaviour 3 weeks post-training, indicating that reconsolidation of reward-related memories can be disrupted after a long post-training interval.

KW - Adrenergic beta-Antagonists

KW - Analysis of Variance

KW - Animals

KW - Behavior, Animal

KW - Inhibition (Psychology)

KW - Male

KW - Memory

KW - Propranolol

KW - Rats

KW - Rats, Wistar

KW - Receptors, Adrenergic, beta

KW - Reward

KW - Time Factors

KW - Comparative Study

KW - Journal Article

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DO - 10.1016/j.bbr.2006.02.014

M3 - Article

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SP - 333

EP - 336

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

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ER -