Beta-adrenoceptor mediated inhibition of long-term reward-related memory reconsolidation

Leontien Diergaarde, Anton N M Schoffelmeer, Taco J De Vries

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Well-consolidated fear-related memories, once retrieved, are susceptible to disruption and require reconsolidation in order to be maintained. We examined whether reactivated reward-related memories are also susceptible to interference by evaluating the effect of propranolol (PROP), a beta-adrenergic antagonist known to impair reconsolidation of fear-related memories, on context-induced sucrose seeking. PROP administration upon reactivation reduced sucrose seeking behaviour 3 weeks post-training, indicating that reconsolidation of reward-related memories can be disrupted after a long post-training interval.

Original languageEnglish
Pages (from-to)333-6
Number of pages4
JournalBehavioural Brain Research
Issue number2
Publication statusPublished - 30 Jun 2006

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