TY - JOUR
T1 - Bilateral pulmonary infiltrates in a patient with ulcerative colitis receiving mesalazine
AU - Nanayakkara, Prabath W.B.
AU - De Jong, Evelien
AU - Postmus, Piet E.
PY - 2004/11/1
Y1 - 2004/11/1
N2 - A 36-year-old woman presented with a 2-month history of dry cough, bilateral pain in the upper chest, and low-grade fever. She had a 1-year history of ulcerative colitis (UC), which was treated with mesalazine. Cultures of sputum and bronchoalveolar lavage (BAL) fluid were negative. Chest radiograph and a computed tomography (CT) scan showed dense bilateral subpleural infiltrates in both upper lobes. A c-ANCA test was positive in a 1:1280 titer, and further specification showed antibodies against proteinase-3 antigen. Due to the possibility of mesalazine toxicity, this medication was stopped. Within 2 weeks, the patient's symptoms markedly improved, together with the chest roëntgenogram.
AB - A 36-year-old woman presented with a 2-month history of dry cough, bilateral pain in the upper chest, and low-grade fever. She had a 1-year history of ulcerative colitis (UC), which was treated with mesalazine. Cultures of sputum and bronchoalveolar lavage (BAL) fluid were negative. Chest radiograph and a computed tomography (CT) scan showed dense bilateral subpleural infiltrates in both upper lobes. A c-ANCA test was positive in a 1:1280 titer, and further specification showed antibodies against proteinase-3 antigen. Due to the possibility of mesalazine toxicity, this medication was stopped. Within 2 weeks, the patient's symptoms markedly improved, together with the chest roëntgenogram.
KW - c-ANCA
KW - Mesalazine
KW - Pulmonary toxicity
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=9744222627&partnerID=8YFLogxK
U2 - 10.1016/j.ejim.2004.08.007
DO - 10.1016/j.ejim.2004.08.007
M3 - Article
AN - SCOPUS:9744222627
VL - 15
SP - 470
EP - 472
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
SN - 0953-6205
IS - 7
ER -