Bilateral pulmonary infiltrates in a patient with ulcerative colitis receiving mesalazine

Prabath W.B. Nanayakkara; Evelien De Jong; Piet E. Postmus

doi:10.1016/j.ejim.2004.08.007

Bilateral pulmonary infiltrates in a patient with ulcerative colitis receiving mesalazine

Prabath W.B. Nanayakkara, Evelien De Jong, Piet E. Postmus

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A 36-year-old woman presented with a 2-month history of dry cough, bilateral pain in the upper chest, and low-grade fever. She had a 1-year history of ulcerative colitis (UC), which was treated with mesalazine. Cultures of sputum and bronchoalveolar lavage (BAL) fluid were negative. Chest radiograph and a computed tomography (CT) scan showed dense bilateral subpleural infiltrates in both upper lobes. A c-ANCA test was positive in a 1:1280 titer, and further specification showed antibodies against proteinase-3 antigen. Due to the possibility of mesalazine toxicity, this medication was stopped. Within 2 weeks, the patient's symptoms markedly improved, together with the chest roëntgenogram.

Original language	English
Pages (from-to)	470-472
Number of pages	3
Journal	European Journal of Internal Medicine
Volume	15
Issue number	7
DOIs	https://doi.org/10.1016/j.ejim.2004.08.007
Publication status	Published - 1 Nov 2004

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10.1016/j.ejim.2004.08.007

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Cite this

Nanayakkara, P. W. B., De Jong, E., & Postmus, P. E. (2004). Bilateral pulmonary infiltrates in a patient with ulcerative colitis receiving mesalazine. European Journal of Internal Medicine, 15(7), 470-472. https://doi.org/10.1016/j.ejim.2004.08.007

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title = "Bilateral pulmonary infiltrates in a patient with ulcerative colitis receiving mesalazine",

abstract = "A 36-year-old woman presented with a 2-month history of dry cough, bilateral pain in the upper chest, and low-grade fever. She had a 1-year history of ulcerative colitis (UC), which was treated with mesalazine. Cultures of sputum and bronchoalveolar lavage (BAL) fluid were negative. Chest radiograph and a computed tomography (CT) scan showed dense bilateral subpleural infiltrates in both upper lobes. A c-ANCA test was positive in a 1:1280 titer, and further specification showed antibodies against proteinase-3 antigen. Due to the possibility of mesalazine toxicity, this medication was stopped. Within 2 weeks, the patient's symptoms markedly improved, together with the chest ro{\"e}ntgenogram.",

keywords = "c-ANCA, Mesalazine, Pulmonary toxicity, Ulcerative colitis",

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AU - Nanayakkara, Prabath W.B.

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AU - Postmus, Piet E.

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AB - A 36-year-old woman presented with a 2-month history of dry cough, bilateral pain in the upper chest, and low-grade fever. She had a 1-year history of ulcerative colitis (UC), which was treated with mesalazine. Cultures of sputum and bronchoalveolar lavage (BAL) fluid were negative. Chest radiograph and a computed tomography (CT) scan showed dense bilateral subpleural infiltrates in both upper lobes. A c-ANCA test was positive in a 1:1280 titer, and further specification showed antibodies against proteinase-3 antigen. Due to the possibility of mesalazine toxicity, this medication was stopped. Within 2 weeks, the patient's symptoms markedly improved, together with the chest roëntgenogram.

KW - c-ANCA

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