Tumorlokalisaties op PSMA-PET/CT bij patiënten met een persisterend meetbaar PSA na een radicale prostatectomie

Translated title of the contribution: Biochemical persistence of prostate-specific antigen after robot-assisted laparoscopic radical prostatectomy: tumor localizations using PSMA-PET/CT imaging

Rosemarijn H. Ettema, Dennie Meijer*, Maarten L. Donswijk, Yves J.L. Bodar, Pim J. van Leeuwen, Henk G. van der Poel, Wouter V. Vogel, Jakko A. Nieuwenhuijzen, N. Harry Hendrikse, Daniela E. Oprea-Lager, André N. Vis

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The aim of this study was to determine the role of PSMA-PET/CT imaging in patients who experience biochemical persistence (BCP) after robot-assisted laparoscopic radical prostatectomy (RARP). 150 patients with BCP after RARP who underwent radiolabeled PSMA-PET/CT imaging were evaluated. A multivariable logistic regression analysis was performed to identify predictors for the detection of metastases outside the prostatic fossa (≥ miN1) on PSMA-PET/CT. Results: In total, 89/150 patients (59%) had ≥ miN1 on PSMA-PET/CT at BCP. On multivariable analysis, higher PSA-values after RARP (p = 0.004) and positive pathological lymph node status (p = 0.006) were independent predictors for ≥ miN1. In presence of BCP, a high proportion of patients had ≥ miN1 disease, indicated by PSMA-PET/CT. Higher PSA-levels after RARP and positive pathological lymph node status were significantly associated with metastases outside the prostatic fossa. In conclusion, in patients with BCP, PSMA-PET/CT imaging is warranted to guide (salvage) treatment strategies.

Translated title of the contributionBiochemical persistence of prostate-specific antigen after robot-assisted laparoscopic radical prostatectomy: tumor localizations using PSMA-PET/CT imaging
Original languageDutch
Pages (from-to)54-61
Number of pages8
JournalTijdschrift voor Urologie
Volume11
Issue number4
DOIs
Publication statusPublished - Jul 2021

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