Bioimpedance spectroscopy imprecisely assesses lean body mass in pediatric dialysis patients

Gregorio P. Milani, Jaap W. Groothoff, Federica A. Vianello, Emilio F. Fossali, Fabio Paglialonga, Sivia Consolo, Alberto Edefonti, Dario Consonni, Dewi van Harskamp, Johannes B. van Goudoever, Henk Schierbeek, Carlo Agostoni, Michiel J. S. Oosterveld

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives: Alterations in body compositions are strongly associated with poor outcomes in end-stage renal disease patients. Hence, assessment of lean body mass is crucial for clinically monitoring these patients. The use of multifrequency bioimpedance spectroscopy measurements has also been advocated, but their usefulness in children is questioned. We investigated whether their application is appropriate for lean body mass measurement in pediatric patients receiving chronic dialysis. Methods: Lean body mass estimates as assessed by multifrequency bioimpedance spectroscopy and by deuterium dilution were obtained for 15 patients (mean age 10.9 3.6 years). Results: Lean body mass (mean standard deviation) determined by bioimpedance was 24.2 10.7 and 24.4 10.3 kg by deuterium technique. Bland-Altman analysis showed a mean (standard deviation) difference between the 2 methods of 0.25 2.30 kg with 95% limits of agreement of 4.80 to 4.25 kg. In a multiple linear regression model, the hydration status was associated with measurement bias after adjusting for age, sex, weight, and body surface area. Conclusions: Our results show a high level of agreement between measurements by bioimpedance and deuterium technique, but the limits of agreement were wide. These findings do not support the use of bioimpedance to individually assess lean body mass in pediatric dialysis patients with and without overhydration.
Original languageEnglish
Pages (from-to)533-537
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume67
Issue number4
DOIs
Publication statusPublished - 2018

Cite this

Milani, Gregorio P. ; Groothoff, Jaap W. ; Vianello, Federica A. ; Fossali, Emilio F. ; Paglialonga, Fabio ; Consolo, Sivia ; Edefonti, Alberto ; Consonni, Dario ; van Harskamp, Dewi ; van Goudoever, Johannes B. ; Schierbeek, Henk ; Agostoni, Carlo ; Oosterveld, Michiel J. S. / Bioimpedance spectroscopy imprecisely assesses lean body mass in pediatric dialysis patients. In: Journal of Pediatric Gastroenterology and Nutrition. 2018 ; Vol. 67, No. 4. pp. 533-537.
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abstract = "Objectives: Alterations in body compositions are strongly associated with poor outcomes in end-stage renal disease patients. Hence, assessment of lean body mass is crucial for clinically monitoring these patients. The use of multifrequency bioimpedance spectroscopy measurements has also been advocated, but their usefulness in children is questioned. We investigated whether their application is appropriate for lean body mass measurement in pediatric patients receiving chronic dialysis. Methods: Lean body mass estimates as assessed by multifrequency bioimpedance spectroscopy and by deuterium dilution were obtained for 15 patients (mean age 10.9 3.6 years). Results: Lean body mass (mean standard deviation) determined by bioimpedance was 24.2 10.7 and 24.4 10.3 kg by deuterium technique. Bland-Altman analysis showed a mean (standard deviation) difference between the 2 methods of 0.25 2.30 kg with 95{\%} limits of agreement of 4.80 to 4.25 kg. In a multiple linear regression model, the hydration status was associated with measurement bias after adjusting for age, sex, weight, and body surface area. Conclusions: Our results show a high level of agreement between measurements by bioimpedance and deuterium technique, but the limits of agreement were wide. These findings do not support the use of bioimpedance to individually assess lean body mass in pediatric dialysis patients with and without overhydration.",
author = "Milani, {Gregorio P.} and Groothoff, {Jaap W.} and Vianello, {Federica A.} and Fossali, {Emilio F.} and Fabio Paglialonga and Sivia Consolo and Alberto Edefonti and Dario Consonni and {van Harskamp}, Dewi and {van Goudoever}, {Johannes B.} and Henk Schierbeek and Carlo Agostoni and Oosterveld, {Michiel J. S.}",
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Bioimpedance spectroscopy imprecisely assesses lean body mass in pediatric dialysis patients. / Milani, Gregorio P.; Groothoff, Jaap W.; Vianello, Federica A.; Fossali, Emilio F.; Paglialonga, Fabio; Consolo, Sivia; Edefonti, Alberto; Consonni, Dario; van Harskamp, Dewi; van Goudoever, Johannes B.; Schierbeek, Henk; Agostoni, Carlo; Oosterveld, Michiel J. S.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 67, No. 4, 2018, p. 533-537.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Bioimpedance spectroscopy imprecisely assesses lean body mass in pediatric dialysis patients

AU - Milani, Gregorio P.

AU - Groothoff, Jaap W.

AU - Vianello, Federica A.

AU - Fossali, Emilio F.

AU - Paglialonga, Fabio

AU - Consolo, Sivia

AU - Edefonti, Alberto

AU - Consonni, Dario

AU - van Harskamp, Dewi

AU - van Goudoever, Johannes B.

AU - Schierbeek, Henk

AU - Agostoni, Carlo

AU - Oosterveld, Michiel J. S.

PY - 2018

Y1 - 2018

N2 - Objectives: Alterations in body compositions are strongly associated with poor outcomes in end-stage renal disease patients. Hence, assessment of lean body mass is crucial for clinically monitoring these patients. The use of multifrequency bioimpedance spectroscopy measurements has also been advocated, but their usefulness in children is questioned. We investigated whether their application is appropriate for lean body mass measurement in pediatric patients receiving chronic dialysis. Methods: Lean body mass estimates as assessed by multifrequency bioimpedance spectroscopy and by deuterium dilution were obtained for 15 patients (mean age 10.9 3.6 years). Results: Lean body mass (mean standard deviation) determined by bioimpedance was 24.2 10.7 and 24.4 10.3 kg by deuterium technique. Bland-Altman analysis showed a mean (standard deviation) difference between the 2 methods of 0.25 2.30 kg with 95% limits of agreement of 4.80 to 4.25 kg. In a multiple linear regression model, the hydration status was associated with measurement bias after adjusting for age, sex, weight, and body surface area. Conclusions: Our results show a high level of agreement between measurements by bioimpedance and deuterium technique, but the limits of agreement were wide. These findings do not support the use of bioimpedance to individually assess lean body mass in pediatric dialysis patients with and without overhydration.

AB - Objectives: Alterations in body compositions are strongly associated with poor outcomes in end-stage renal disease patients. Hence, assessment of lean body mass is crucial for clinically monitoring these patients. The use of multifrequency bioimpedance spectroscopy measurements has also been advocated, but their usefulness in children is questioned. We investigated whether their application is appropriate for lean body mass measurement in pediatric patients receiving chronic dialysis. Methods: Lean body mass estimates as assessed by multifrequency bioimpedance spectroscopy and by deuterium dilution were obtained for 15 patients (mean age 10.9 3.6 years). Results: Lean body mass (mean standard deviation) determined by bioimpedance was 24.2 10.7 and 24.4 10.3 kg by deuterium technique. Bland-Altman analysis showed a mean (standard deviation) difference between the 2 methods of 0.25 2.30 kg with 95% limits of agreement of 4.80 to 4.25 kg. In a multiple linear regression model, the hydration status was associated with measurement bias after adjusting for age, sex, weight, and body surface area. Conclusions: Our results show a high level of agreement between measurements by bioimpedance and deuterium technique, but the limits of agreement were wide. These findings do not support the use of bioimpedance to individually assess lean body mass in pediatric dialysis patients with and without overhydration.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/29916952

U2 - 10.1097/MPG.0000000000002063

DO - 10.1097/MPG.0000000000002063

M3 - Article

VL - 67

SP - 533

EP - 537

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 4

ER -