Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

Jonathan R. I. Coleman, Julien Bryois, H. léna A. Gaspar, Philip R. Jansen, Jeanne E. Savage, Nathan Skene, Robert Plomin, Ana B. Muñoz-Manchado, Sten Linnarsson, Greg Crawford, Jens Hjerling-Leffler, Patrick F. Sullivan, Danielle Posthuma, Gerome Breen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated with intelligence. GWAS data for IQ (N = 78,308) were meta-analyzed with a study comparing 1247 individuals with mean IQ ~170 to 8185 controls. Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment for frontal cortex brain expressed genes. These results suggest specific neuronal cell types and genes may be involved in intelligence and provide new hypotheses for neuroscience experiments using model systems.
LanguageEnglish
Pages182-197
Number of pages16
JournalMolecular Psychiatry
Volume24
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

Cite this

Coleman, J. R. I., Bryois, J., Gaspar, H. L. A., Jansen, P. R., Savage, J. E., Skene, N., ... Breen, G. (2019). Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. Molecular Psychiatry, 24(2), 182-197. https://doi.org/10.1038/s41380-018-0040-6
Coleman, Jonathan R. I. ; Bryois, Julien ; Gaspar, H. léna A. ; Jansen, Philip R. ; Savage, Jeanne E. ; Skene, Nathan ; Plomin, Robert ; Muñoz-Manchado, Ana B. ; Linnarsson, Sten ; Crawford, Greg ; Hjerling-Leffler, Jens ; Sullivan, Patrick F. ; Posthuma, Danielle ; Breen, Gerome. / Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. In: Molecular Psychiatry. 2019 ; Vol. 24, No. 2. pp. 182-197.
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Coleman, JRI, Bryois, J, Gaspar, HLA, Jansen, PR, Savage, JE, Skene, N, Plomin, R, Muñoz-Manchado, AB, Linnarsson, S, Crawford, G, Hjerling-Leffler, J, Sullivan, PF, Posthuma, D & Breen, G 2019, 'Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals', Molecular Psychiatry, vol. 24, no. 2, pp. 182-197. https://doi.org/10.1038/s41380-018-0040-6

Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. / Coleman, Jonathan R. I.; Bryois, Julien; Gaspar, H. léna A.; Jansen, Philip R.; Savage, Jeanne E.; Skene, Nathan; Plomin, Robert; Muñoz-Manchado, Ana B.; Linnarsson, Sten; Crawford, Greg; Hjerling-Leffler, Jens; Sullivan, Patrick F.; Posthuma, Danielle; Breen, Gerome.

In: Molecular Psychiatry, Vol. 24, No. 2, 01.02.2019, p. 182-197.

Research output: Contribution to journalArticleAcademicpeer-review

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