Biology of IL-8-induced stem cell mobilization

W E Fibbe, J F Pruijt, G A Velders, G Opdenakker, Y van Kooyk, C G Figdor, R Willemze

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The CXC chemokine interleukin-8 (IL-8) has profound hematopoietic activities following systemic administration. It induces the rapid mobilization of cells with lymphomyeloid repopulating ability in mice and of hematopoietic progenitor cells in monkeys. In this paper, evidence is presented that stem cell mobilization in mice requires the functional expression on the beta 2-integrin leukocyte function-associated antigen-1 (LFA-1). In monkeys, systemic injection of IL-8 is followed by a significant increase in the circulating levels of the matrix metallo proteinase gelatinase-B (MMP-9). Based on these findings, the hypothesis is discussed that mature neutrophils serve as intermediate cells in IL-8-induced stem cell mobilization by the release of proteinases.

Original languageEnglish
Pages (from-to)71-82
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume872
Publication statusPublished - 30 Apr 1999

Cite this

Fibbe, W. E., Pruijt, J. F., Velders, G. A., Opdenakker, G., van Kooyk, Y., Figdor, C. G., & Willemze, R. (1999). Biology of IL-8-induced stem cell mobilization. Annals of the New York Academy of Sciences, 872, 71-82.
Fibbe, W E ; Pruijt, J F ; Velders, G A ; Opdenakker, G ; van Kooyk, Y ; Figdor, C G ; Willemze, R. / Biology of IL-8-induced stem cell mobilization. In: Annals of the New York Academy of Sciences. 1999 ; Vol. 872. pp. 71-82.
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title = "Biology of IL-8-induced stem cell mobilization",
abstract = "The CXC chemokine interleukin-8 (IL-8) has profound hematopoietic activities following systemic administration. It induces the rapid mobilization of cells with lymphomyeloid repopulating ability in mice and of hematopoietic progenitor cells in monkeys. In this paper, evidence is presented that stem cell mobilization in mice requires the functional expression on the beta 2-integrin leukocyte function-associated antigen-1 (LFA-1). In monkeys, systemic injection of IL-8 is followed by a significant increase in the circulating levels of the matrix metallo proteinase gelatinase-B (MMP-9). Based on these findings, the hypothesis is discussed that mature neutrophils serve as intermediate cells in IL-8-induced stem cell mobilization by the release of proteinases.",
keywords = "Animals, Cell Adhesion Molecules/physiology, Hematopoietic Stem Cell Mobilization/methods, Hematopoietic Stem Cells/cytology, Humans, Interleukin-8/pharmacology, Lymphocyte Function-Associated Antigen-1/biosynthesis, Macaca mulatta, Metalloendopeptidases/metabolism, Mice",
author = "Fibbe, {W E} and Pruijt, {J F} and Velders, {G A} and G Opdenakker and {van Kooyk}, Y and Figdor, {C G} and R Willemze",
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Fibbe, WE, Pruijt, JF, Velders, GA, Opdenakker, G, van Kooyk, Y, Figdor, CG & Willemze, R 1999, 'Biology of IL-8-induced stem cell mobilization' Annals of the New York Academy of Sciences, vol. 872, pp. 71-82.

Biology of IL-8-induced stem cell mobilization. / Fibbe, W E; Pruijt, J F; Velders, G A; Opdenakker, G; van Kooyk, Y; Figdor, C G; Willemze, R.

In: Annals of the New York Academy of Sciences, Vol. 872, 30.04.1999, p. 71-82.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Biology of IL-8-induced stem cell mobilization

AU - Fibbe, W E

AU - Pruijt, J F

AU - Velders, G A

AU - Opdenakker, G

AU - van Kooyk, Y

AU - Figdor, C G

AU - Willemze, R

PY - 1999/4/30

Y1 - 1999/4/30

N2 - The CXC chemokine interleukin-8 (IL-8) has profound hematopoietic activities following systemic administration. It induces the rapid mobilization of cells with lymphomyeloid repopulating ability in mice and of hematopoietic progenitor cells in monkeys. In this paper, evidence is presented that stem cell mobilization in mice requires the functional expression on the beta 2-integrin leukocyte function-associated antigen-1 (LFA-1). In monkeys, systemic injection of IL-8 is followed by a significant increase in the circulating levels of the matrix metallo proteinase gelatinase-B (MMP-9). Based on these findings, the hypothesis is discussed that mature neutrophils serve as intermediate cells in IL-8-induced stem cell mobilization by the release of proteinases.

AB - The CXC chemokine interleukin-8 (IL-8) has profound hematopoietic activities following systemic administration. It induces the rapid mobilization of cells with lymphomyeloid repopulating ability in mice and of hematopoietic progenitor cells in monkeys. In this paper, evidence is presented that stem cell mobilization in mice requires the functional expression on the beta 2-integrin leukocyte function-associated antigen-1 (LFA-1). In monkeys, systemic injection of IL-8 is followed by a significant increase in the circulating levels of the matrix metallo proteinase gelatinase-B (MMP-9). Based on these findings, the hypothesis is discussed that mature neutrophils serve as intermediate cells in IL-8-induced stem cell mobilization by the release of proteinases.

KW - Animals

KW - Cell Adhesion Molecules/physiology

KW - Hematopoietic Stem Cell Mobilization/methods

KW - Hematopoietic Stem Cells/cytology

KW - Humans

KW - Interleukin-8/pharmacology

KW - Lymphocyte Function-Associated Antigen-1/biosynthesis

KW - Macaca mulatta

KW - Metalloendopeptidases/metabolism

KW - Mice

M3 - Review article

VL - 872

SP - 71

EP - 82

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -

Fibbe WE, Pruijt JF, Velders GA, Opdenakker G, van Kooyk Y, Figdor CG et al. Biology of IL-8-induced stem cell mobilization. Annals of the New York Academy of Sciences. 1999 Apr 30;872:71-82.