Biomechanical response of the CNS is associated with frailty in NPH-suspected patients

A. Vallet, N. Del Campo, E. O. Hoogendijk, A. Lokossou, O. Balédent, Z. Czosnyka, L. Balardy, P. Payoux, P. Swider, S. Lorthois, E. Schmidt

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) presenting with markers of multiple co-existing pathologies. The biomechanical response of the CNS was characterized by the CNS elastance coefficient inferred from phase contrast magnetic resonance imaging and intracranial pressure monitoring during a lumbar infusion test. Frailty was assessed with an index of health deficit accumulation. We found a significant association between the CNS elastance coefficient and frailty, with an effect size comparable to that between frailty and age, the latter being the strongest known risk factor for frailty. Results were independent of CSF dynamics, showing that they are not specific to the NPH neuropathological condition. The CNS biomechanical characterization may help to understand how frailty is related to neurodegeneration and detect the shift from normal to pathological brain ageing.

Original languageEnglish
JournalJournal of Neurology
DOIs
Publication statusE-pub ahead of print - 1 Jan 2020

Cite this

Vallet, A. ; Del Campo, N. ; Hoogendijk, E. O. ; Lokossou, A. ; Balédent, O. ; Czosnyka, Z. ; Balardy, L. ; Payoux, P. ; Swider, P. ; Lorthois, S. ; Schmidt, E. / Biomechanical response of the CNS is associated with frailty in NPH-suspected patients. In: Journal of Neurology. 2020.
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abstract = "Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) presenting with markers of multiple co-existing pathologies. The biomechanical response of the CNS was characterized by the CNS elastance coefficient inferred from phase contrast magnetic resonance imaging and intracranial pressure monitoring during a lumbar infusion test. Frailty was assessed with an index of health deficit accumulation. We found a significant association between the CNS elastance coefficient and frailty, with an effect size comparable to that between frailty and age, the latter being the strongest known risk factor for frailty. Results were independent of CSF dynamics, showing that they are not specific to the NPH neuropathological condition. The CNS biomechanical characterization may help to understand how frailty is related to neurodegeneration and detect the shift from normal to pathological brain ageing.",
keywords = "Biomechanics, Frailty, Lumbar infusion test, Neurodegenerative CNS changes, Normal pressure hydrocephalus, Phase contrast magnetic resonance imaging",
author = "A. Vallet and {Del Campo}, N. and Hoogendijk, {E. O.} and A. Lokossou and O. Bal{\'e}dent and Z. Czosnyka and L. Balardy and P. Payoux and P. Swider and S. Lorthois and E. Schmidt",
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Vallet, A, Del Campo, N, Hoogendijk, EO, Lokossou, A, Balédent, O, Czosnyka, Z, Balardy, L, Payoux, P, Swider, P, Lorthois, S & Schmidt, E 2020, 'Biomechanical response of the CNS is associated with frailty in NPH-suspected patients' Journal of Neurology. https://doi.org/10.1007/s00415-019-09689-z

Biomechanical response of the CNS is associated with frailty in NPH-suspected patients. / Vallet, A.; Del Campo, N.; Hoogendijk, E. O.; Lokossou, A.; Balédent, O.; Czosnyka, Z.; Balardy, L.; Payoux, P.; Swider, P.; Lorthois, S.; Schmidt, E.

In: Journal of Neurology, 01.01.2020.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Vallet, A.

AU - Del Campo, N.

AU - Hoogendijk, E. O.

AU - Lokossou, A.

AU - Balédent, O.

AU - Czosnyka, Z.

AU - Balardy, L.

AU - Payoux, P.

AU - Swider, P.

AU - Lorthois, S.

AU - Schmidt, E.

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N2 - Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) presenting with markers of multiple co-existing pathologies. The biomechanical response of the CNS was characterized by the CNS elastance coefficient inferred from phase contrast magnetic resonance imaging and intracranial pressure monitoring during a lumbar infusion test. Frailty was assessed with an index of health deficit accumulation. We found a significant association between the CNS elastance coefficient and frailty, with an effect size comparable to that between frailty and age, the latter being the strongest known risk factor for frailty. Results were independent of CSF dynamics, showing that they are not specific to the NPH neuropathological condition. The CNS biomechanical characterization may help to understand how frailty is related to neurodegeneration and detect the shift from normal to pathological brain ageing.

AB - Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) presenting with markers of multiple co-existing pathologies. The biomechanical response of the CNS was characterized by the CNS elastance coefficient inferred from phase contrast magnetic resonance imaging and intracranial pressure monitoring during a lumbar infusion test. Frailty was assessed with an index of health deficit accumulation. We found a significant association between the CNS elastance coefficient and frailty, with an effect size comparable to that between frailty and age, the latter being the strongest known risk factor for frailty. Results were independent of CSF dynamics, showing that they are not specific to the NPH neuropathological condition. The CNS biomechanical characterization may help to understand how frailty is related to neurodegeneration and detect the shift from normal to pathological brain ageing.

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