Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation

Nadine G. Pakker, Daan W. Notermans, Rob J. De Boer, Marijke T.L. Roos, Frank De Wolf, Andrew Hill, John M. Leonard, Sven A. Danner, Frank Miedema*, Peter T.A. Schellekens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T- cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalNature Medicine
Volume4
Issue number2
DOIs
Publication statusPublished - 1998

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