Birth defect and risk factor surveillance in the northern and southwestern Netherlands

J. Reefhuis, G. R J Zandwijken, H. E K De Walle, M. C. Cornel

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To survey the associations between several risk factors and birth defects, in order to detect potential new teratogens. Methods: Data of the two Dutch European Registration of Congenital Anomalies (EUROCAT) registries collected before January 1, 1998 were used to perform X2 tests for a large number of risk factors and birth defects. Defects caused by chromosomal or monogenic disorders were analyzed separately. Results: Cross- tabulations of 80 groups of birth defects with 303 risk factors were studied. Of these, 126 combinations had a p value under 0.05, and 34 had a p value under 0.001. Of these 34 associations, some are known in the literature, some were found before in the same databases and some were new associations. Conclusions: This is a good method for generating new hypotheses for associations between risk factors and birth defects. It can be a start for new, more in-depth studies of potential teratogens. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalCommunity Genetics
Volume2
Issue number2-3
Publication statusPublished - 1 Dec 1999
Externally publishedYes

Cite this

Reefhuis, J., Zandwijken, G. R. J., De Walle, H. E. K., & Cornel, M. C. (1999). Birth defect and risk factor surveillance in the northern and southwestern Netherlands. Community Genetics, 2(2-3), 97-108.
Reefhuis, J. ; Zandwijken, G. R J ; De Walle, H. E K ; Cornel, M. C. / Birth defect and risk factor surveillance in the northern and southwestern Netherlands. In: Community Genetics. 1999 ; Vol. 2, No. 2-3. pp. 97-108.
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Reefhuis, J, Zandwijken, GRJ, De Walle, HEK & Cornel, MC 1999, 'Birth defect and risk factor surveillance in the northern and southwestern Netherlands' Community Genetics, vol. 2, no. 2-3, pp. 97-108.

Birth defect and risk factor surveillance in the northern and southwestern Netherlands. / Reefhuis, J.; Zandwijken, G. R J; De Walle, H. E K; Cornel, M. C.

In: Community Genetics, Vol. 2, No. 2-3, 01.12.1999, p. 97-108.

Research output: Contribution to journalArticleAcademicpeer-review

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