Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Postmortem MRI-guided tissue sampling significantly enhances the yield of MS lesions in autopsy material, but so far it is unknown whether abnormalities concur with blood-brain barrier alterations. Here we sampled MS lesions with focal and diffuse abnormalities (diffusely abnormal white matter; DAWM) on MRI; both were coupled to the presence of MS lesions upon neuropathological examination. Extravascular distribution of fibrinogen, indicating BBB disturbance, was observed in so-called (p)reactive lesions that reflect discrete areas of microglial activation without demyelination within an otherwise normal appearing white matter. Leakage became more extensive in active demyelinating MS lesions to chronic inactive lesions. An enlargement of the perivascular (Virchow-Robin) space containing infiltrated leukocytes was associated with both DAWM and focal abnormalities on postmortem MRI. This study shows for the first time that in MS brain changes in the vasculature take place not only in focal lesions but also in DAWM as detected by postmortem MRI. © 2005 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)953-960
JournalNeurobiology of Disease
Volume20
Issue number3
DOIs
Publication statusPublished - 2005

Cite this

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title = "Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis",
abstract = "Postmortem MRI-guided tissue sampling significantly enhances the yield of MS lesions in autopsy material, but so far it is unknown whether abnormalities concur with blood-brain barrier alterations. Here we sampled MS lesions with focal and diffuse abnormalities (diffusely abnormal white matter; DAWM) on MRI; both were coupled to the presence of MS lesions upon neuropathological examination. Extravascular distribution of fibrinogen, indicating BBB disturbance, was observed in so-called (p)reactive lesions that reflect discrete areas of microglial activation without demyelination within an otherwise normal appearing white matter. Leakage became more extensive in active demyelinating MS lesions to chronic inactive lesions. An enlargement of the perivascular (Virchow-Robin) space containing infiltrated leukocytes was associated with both DAWM and focal abnormalities on postmortem MRI. This study shows for the first time that in MS brain changes in the vasculature take place not only in focal lesions but also in DAWM as detected by postmortem MRI. {\circledC} 2005 Elsevier Inc. All rights reserved.",
author = "Vos, {Catharina M. P.} and Geurts, {Jeroen J. G.} and Lisette Montagne and {van Haastert}, {Elise S.} and Lars B{\"o} and {van der Valk}, Paul and Frederik Barkhof and {de Vries}, {Helga E.}",
year = "2005",
doi = "10.1016/j.nbd.2005.06.012",
language = "English",
volume = "20",
pages = "953--960",
journal = "Neurobiology of Disease",
issn = "0969-9961",
publisher = "Academic Press Inc.",
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Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis. / Vos, Catharina M. P.; Geurts, Jeroen J. G.; Montagne, Lisette; van Haastert, Elise S.; Bö, Lars; van der Valk, Paul; Barkhof, Frederik; de Vries, Helga E.

In: Neurobiology of Disease, Vol. 20, No. 3, 2005, p. 953-960.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

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AU - Vos, Catharina M. P.

AU - Geurts, Jeroen J. G.

AU - Montagne, Lisette

AU - van Haastert, Elise S.

AU - Bö, Lars

AU - van der Valk, Paul

AU - Barkhof, Frederik

AU - de Vries, Helga E.

PY - 2005

Y1 - 2005

N2 - Postmortem MRI-guided tissue sampling significantly enhances the yield of MS lesions in autopsy material, but so far it is unknown whether abnormalities concur with blood-brain barrier alterations. Here we sampled MS lesions with focal and diffuse abnormalities (diffusely abnormal white matter; DAWM) on MRI; both were coupled to the presence of MS lesions upon neuropathological examination. Extravascular distribution of fibrinogen, indicating BBB disturbance, was observed in so-called (p)reactive lesions that reflect discrete areas of microglial activation without demyelination within an otherwise normal appearing white matter. Leakage became more extensive in active demyelinating MS lesions to chronic inactive lesions. An enlargement of the perivascular (Virchow-Robin) space containing infiltrated leukocytes was associated with both DAWM and focal abnormalities on postmortem MRI. This study shows for the first time that in MS brain changes in the vasculature take place not only in focal lesions but also in DAWM as detected by postmortem MRI. © 2005 Elsevier Inc. All rights reserved.

AB - Postmortem MRI-guided tissue sampling significantly enhances the yield of MS lesions in autopsy material, but so far it is unknown whether abnormalities concur with blood-brain barrier alterations. Here we sampled MS lesions with focal and diffuse abnormalities (diffusely abnormal white matter; DAWM) on MRI; both were coupled to the presence of MS lesions upon neuropathological examination. Extravascular distribution of fibrinogen, indicating BBB disturbance, was observed in so-called (p)reactive lesions that reflect discrete areas of microglial activation without demyelination within an otherwise normal appearing white matter. Leakage became more extensive in active demyelinating MS lesions to chronic inactive lesions. An enlargement of the perivascular (Virchow-Robin) space containing infiltrated leukocytes was associated with both DAWM and focal abnormalities on postmortem MRI. This study shows for the first time that in MS brain changes in the vasculature take place not only in focal lesions but also in DAWM as detected by postmortem MRI. © 2005 Elsevier Inc. All rights reserved.

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