Bone health in adult trans persons: An update of the literature

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Purpose of review Hormonal treatment in trans persons can affect bone health. In this review, recent studies published on this topic in adults are discussed. Recent findings Before starting hormonal treatment, trans women were found to have lower bone mineral density than cis men, which seems to be related to lower vitamin D concentrations and lower lean body mass, whereas this was not found in trans men. Short-term and long-term studies show that hormonal treatment does not have detrimental effects on bone mineral density in trans women and trans men. Low estradiol concentrations were associated with a decrease in bone mineral density in trans women. Summary Based on the reassuring findings in these studies, regularly assessing bone mineral density during hormonal treatment does not seem necessary. This confirms the Endocrine Society Guideline stating that bone mineral density should be measured only when risk factors for osteoporosis exist, especially in people who stop hormonal treatment after gonadectomy. The relationship with estradiol concentrations indicate that hormone supplementation should be adequate and therapy compliance should be stimulated. As vitamin D deficiency frequently occurs, vitamin D supplementation should be considered. Future research should focus on fracture risk and long-term changes in bone geometry.
Original languageEnglish
JournalCurrent opinion in endocrinology diabetes and obesity
DOIs
Publication statusPublished - 2019

Cite this

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title = "Bone health in adult trans persons: An update of the literature",
abstract = "Purpose of review Hormonal treatment in trans persons can affect bone health. In this review, recent studies published on this topic in adults are discussed. Recent findings Before starting hormonal treatment, trans women were found to have lower bone mineral density than cis men, which seems to be related to lower vitamin D concentrations and lower lean body mass, whereas this was not found in trans men. Short-term and long-term studies show that hormonal treatment does not have detrimental effects on bone mineral density in trans women and trans men. Low estradiol concentrations were associated with a decrease in bone mineral density in trans women. Summary Based on the reassuring findings in these studies, regularly assessing bone mineral density during hormonal treatment does not seem necessary. This confirms the Endocrine Society Guideline stating that bone mineral density should be measured only when risk factors for osteoporosis exist, especially in people who stop hormonal treatment after gonadectomy. The relationship with estradiol concentrations indicate that hormone supplementation should be adequate and therapy compliance should be stimulated. As vitamin D deficiency frequently occurs, vitamin D supplementation should be considered. Future research should focus on fracture risk and long-term changes in bone geometry.",
author = "Wiepjes, {Chantal M.} and {den Heijer}, Martin and t'Sjoen, {Guy G.}",
year = "2019",
doi = "10.1097/MED.0000000000000502",
language = "English",
journal = "Current opinion in endocrinology diabetes and obesity",
issn = "1752-296X",
publisher = "Lippincott Williams and Wilkins",

}

Bone health in adult trans persons: An update of the literature. / Wiepjes, Chantal M.; den Heijer, Martin; t'Sjoen, Guy G.

In: Current opinion in endocrinology diabetes and obesity, 2019.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Bone health in adult trans persons: An update of the literature

AU - Wiepjes, Chantal M.

AU - den Heijer, Martin

AU - t'Sjoen, Guy G.

PY - 2019

Y1 - 2019

N2 - Purpose of review Hormonal treatment in trans persons can affect bone health. In this review, recent studies published on this topic in adults are discussed. Recent findings Before starting hormonal treatment, trans women were found to have lower bone mineral density than cis men, which seems to be related to lower vitamin D concentrations and lower lean body mass, whereas this was not found in trans men. Short-term and long-term studies show that hormonal treatment does not have detrimental effects on bone mineral density in trans women and trans men. Low estradiol concentrations were associated with a decrease in bone mineral density in trans women. Summary Based on the reassuring findings in these studies, regularly assessing bone mineral density during hormonal treatment does not seem necessary. This confirms the Endocrine Society Guideline stating that bone mineral density should be measured only when risk factors for osteoporosis exist, especially in people who stop hormonal treatment after gonadectomy. The relationship with estradiol concentrations indicate that hormone supplementation should be adequate and therapy compliance should be stimulated. As vitamin D deficiency frequently occurs, vitamin D supplementation should be considered. Future research should focus on fracture risk and long-term changes in bone geometry.

AB - Purpose of review Hormonal treatment in trans persons can affect bone health. In this review, recent studies published on this topic in adults are discussed. Recent findings Before starting hormonal treatment, trans women were found to have lower bone mineral density than cis men, which seems to be related to lower vitamin D concentrations and lower lean body mass, whereas this was not found in trans men. Short-term and long-term studies show that hormonal treatment does not have detrimental effects on bone mineral density in trans women and trans men. Low estradiol concentrations were associated with a decrease in bone mineral density in trans women. Summary Based on the reassuring findings in these studies, regularly assessing bone mineral density during hormonal treatment does not seem necessary. This confirms the Endocrine Society Guideline stating that bone mineral density should be measured only when risk factors for osteoporosis exist, especially in people who stop hormonal treatment after gonadectomy. The relationship with estradiol concentrations indicate that hormone supplementation should be adequate and therapy compliance should be stimulated. As vitamin D deficiency frequently occurs, vitamin D supplementation should be considered. Future research should focus on fracture risk and long-term changes in bone geometry.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85073165402&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31573999

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DO - 10.1097/MED.0000000000000502

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JO - Current opinion in endocrinology diabetes and obesity

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SN - 1752-296X

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