Bone marrow provides an environment that prevents suppression oftherapeutic graft-vs.-tumor immunity by regulatory T cells

Teun Guichelaar; Tuna Mutis

doi:10.4161/onci.24659

Bone marrow provides an environment that prevents suppression oftherapeutic graft-vs.-tumor immunity by regulatory T cells

Teun Guichelaar, Tuna Mutis^*

^*Corresponding author for this work

Hematology laboratory

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Regulatory T cells (Tregs) can prevent graft- vs. -host disease as induced by the infusion of donor lymphocytes to cancer patients, but often they also suppress therapeutic antitumor immunity. We discuss an exception to this phenomenon, exemplifying how the milieu provided by the bone marrow may neutralize Tregs to allow local immune responses against cancer.

Original language	English
Article number	e24659
Journal	OncoImmunology
Volume	2
Issue number	7
DOIs	https://doi.org/10.4161/onci.24659
Publication status	Published - 4 Sept 2013

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abstract = "Regulatory T cells (Tregs) can prevent graft- vs. -host disease as induced by the infusion of donor lymphocytes to cancer patients, but often they also suppress therapeutic antitumor immunity. We discuss an exception to this phenomenon, exemplifying how the milieu provided by the bone marrow may neutralize Tregs to allow local immune responses against cancer.",

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N2 - Regulatory T cells (Tregs) can prevent graft- vs. -host disease as induced by the infusion of donor lymphocytes to cancer patients, but often they also suppress therapeutic antitumor immunity. We discuss an exception to this phenomenon, exemplifying how the milieu provided by the bone marrow may neutralize Tregs to allow local immune responses against cancer.

AB - Regulatory T cells (Tregs) can prevent graft- vs. -host disease as induced by the infusion of donor lymphocytes to cancer patients, but often they also suppress therapeutic antitumor immunity. We discuss an exception to this phenomenon, exemplifying how the milieu provided by the bone marrow may neutralize Tregs to allow local immune responses against cancer.

KW - Bone marrow

KW - Graft-versus-host disease

KW - Graft-versus-tumor

KW - Lymphocyte infusion

KW - Regulatory T cell

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Bone marrow provides an environment that prevents suppression oftherapeutic graft-vs.-tumor immunity by regulatory T cells

Abstract

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