Bone marrow provides an environment that prevents suppression oftherapeutic graft-vs.-tumor immunity by regulatory T cells

Teun Guichelaar, Tuna Mutis*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Regulatory T cells (Tregs) can prevent graft- vs. -host disease as induced by the infusion of donor lymphocytes to cancer patients, but often they also suppress therapeutic antitumor immunity. We discuss an exception to this phenomenon, exemplifying how the milieu provided by the bone marrow may neutralize Tregs to allow local immune responses against cancer.

Original languageEnglish
Article numbere24659
JournalOncoImmunology
Volume2
Issue number7
DOIs
Publication statusPublished - 4 Sep 2013

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