Bone mineral density and body composition in Noonan's syndrome: Effects of growth hormone treatment

C. Noordam, J. Span, R. R. van Rijn, E. Gomes-Jardin, C. van Kuijk, B. J. Otten

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We assessed bone mineral density (BMD) and body composition in children with Noonan's syndrome (NS) before and during growth hormone (GH) treatment. Sixteen children (12 boys, 4 girls) with NS aged 5.8-14.2 (mean 10.0) years were studied for 2 years. Anthropometry, BMD measurements by radiographic absorptiometry and bioimpedance measurements (Akern-BIA 101/S) were performed at baseline and after 3, 6, 12 and 24 months. Daily GH dosage was 0.05 mg/kg. Trabecular volumetric BMD was normal; cortical BMD was in the lower normal range at baseline and slightly increased over the 2 years. Fat free mass and total body water were below normal at the start and increased significantly over the first 3 months, with a slight increment thereafter. Percentage fat mass decreased over the first 6 months and increased thereafter. These findings are comparable to the data on body composition in short normal children and girls with Turner's syndrome treated with GH.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume15
Issue number1
Publication statusPublished - 2002

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