Brain microglia in psychiatric disorders

Valeria Mondelli, Anthony C Vernon, Federico Turkheimer, Paola Dazzan, Carmine M Pariante, JL Frost, DP Schafer, RB Banati, J Newcombe, RN Gunn, et al., Y Tang, W Le, ML Estes, AK McAllister, RM Ransohoff, D Davalos, J Grutzendler, G Yang, et al. & 320 others LA Peferoen, DY Vogel, K Ummenthum, et al., DM Norden, PJ Trojanowski, E Villanueva, E Navarro, JP Godbout, T Kreisel, MG Frank, T Licht, et al., S Wachholz, M Eßlinger, J Plümper, MP Manitz, G Juckel, A Friebe, MO Trépanier, KE Hopperton, R Mizrahi, N Mechawar, RP Bazinet, SG Torres-Platas, C Cruceanu, GG Chen, G Turecki, N Mechawar, J Steiner, H Bielau, R Brisch, et al., TP Schnieder, I Trencevska, G Rosoklija, et al., SG Fillman, N Cloonan, VS Catts, et al., R Rupprecht, V Papadopoulos, G Rammes, et al., ZK Qiu, MS Li, JL He, et al., J Hannestad, JD Gallezot, T Schafbauer, et al., I Israel, A Ohsiek, E Al-Momani, et al., N Mirzaei, SP Tang, S Ashworth, et al., B Gulyás, B Makkai, P Kása, et al., FE Turkheimer, G Rizzo, PS Bloomfield, et al., DR Owen, AJ Yeo, RN Gunn, et al., J Hannestad, N DellaGioia, JD Gallezot, et al., E Setiawan, AA Wilson, R Mizrahi, et al., L Su, YO Faluyi, YT Hong, et al., BC Haarman, RF Riemersma-Van der Lek, JC de Groot, et al., BN van Berckel, MG Bossong, R Boellaard, et al., J Doorduin, EF de Vries, AT Willemsen, JC de Groot, RA Dierckx, HC Klein, A Takano, R Arakawa, H Ito, et al., M Kenk, T Selvanathan, N Rao, et al., PS Bloomfield, S Selvaraj, M Veronese, et al., JM Coughlin, Y Wang, EB Ambinder, et al., TF van der Doef, LD de Witte, AL Sutterland, et al., S Hafizi, HH Tseng, N Rao, et al., SE Holmes, R Hinz, RJ Drake, et al., M Yaqub, BN van Berckel, A Schuitemaker, et al., FE Turkheimer, P Edison, N Pavese, et al., A Lockhart, B Davis, JC Matthews, et al., M Quarantelli, C Laule, IM Vavasour, SH Kolind, et al., O Pasternak, N Sochen, Y Gur, N Intrator, Y Assaf, NC Andreasen, JC Ehrhardt, VW Swayze, et al., T Supprian, E Hofmann, M Warmuth-Metz, E Franzek, T Becker, A Pfefferbaum, EV Sullivan, M Hedehus, M Moseley, KO Lim, RC Mandl, HG Schnack, J Luigjes, et al., RC Mandl, O Pasternak, W Cahn, et al., MS Bagary, MR Symms, GJ Barker, SH Mutsatsa, EM Joyce, MA Ron, J Foong, M Maier, GJ Barker, S Brocklehurst, DH Miller, MA Ron, J Foong, MR Symms, GJ Barker, et al., M Kubicki, H Park, CF Westin, et al., MS Bagary, J Foong, M Maier, et al., O Pasternak, CF Westin, S Bouix, O Pasternak, CF Westin, B Dahlben, S Bouix, M Kubicki, LK Oestreich, O Pasternak, ME Shenton, et al., D Amato, CL Beasley, MK Hahn, AC Vernon, AC Vernon, S Natesan, M Modo, S Kapur, V Mondelli, U Reininghaus, MJ Kempton, L Valmaggia, et al., D Baumeister, SL Lightman, CM Pariante, A Danese, TE Moffitt, CM Pariante, A Ambler, R Poulton, A Caspi, D Baumeister, R Akhtar, S Ciufolini, CM Pariante, V Mondelli, U Meyer, AC Vernon, PW So, DJ Lythgoe, et al., MC Cotel, EM Lenartowicz, S Natesan, et al., V Mondelli, C Anacker, AC Vernon, et al., MA Calcia, DR Bonsall, PS Bloomfield, S Selvaraj, T Barichello, OD Howes, NN Burke, CY Fan, T Trang, SB McMahon, F La Russa, DL Bennett, U Püntener, SG Booth, VH Perry, JL Teeling, YK Hahn, EM Podhaizer, SP Farris, MF Miles, KF Hauser, PE Knapp, T Notter, JM Coughlin, T Gschwind, et al., B Varga, K Markó, N Hádinger, et al., A Cattaneo, C Ferrari, R Uher, et al., V Mondelli, S Ciufolini, Murri M Belvederi, et al., CM Sandiego, JD Gallezot, B Pittman, et al., MD Weber, JP Godbout, JF Sheridan, CL Raison, RE Rutherford, BJ Woolwine, et al., T Möller, HW Boddeke, JC O'Connor, MA Lawson, C André, et al., M Hinwood, J Morandini, TA Day, FR Walker, T Möller, F Bard, A Bhattacharya, et al., CU Pae, DM Marks, C Han, AA Patkar, K Oya, T Kishi, N Iwata, D Baumeister, S Ciufolini, V Mondelli

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Summary

The role of immune activation in psychiatric disorders has attracted considerable attention over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the macrophages of the brain, are progressively becoming the main focus of the research in this field. In this Review, we assess the literature on microglia activation across different psychiatric disorders, including post-mortem and in-vivo studies in humans and experimental studies in animals. Although microglia activation has been noted in all types of psychiatric disorder, no association was seen with specific diagnostic categories. Furthermore, the findings from these studies highlight that not all psychiatric patients have microglial activation. Therefore, the cause of the neuroinflammation in these cohorts and its implications are unclear. We discuss psychosocial stress as one of the main factors determining microglial activation in patients with psychiatric disorders, and explore the relevance of these findings for future treatment strategies.

Original languageEnglish
Pages (from-to)587-597
Number of pages11
JournalLancet psychiatry
Volume0
Issue number0
DOIs
Publication statusPublished - 2016

Cite this

Mondelli, V., Vernon, A. C., Turkheimer, F., Dazzan, P., Pariante, C. M., Frost, JL., ... Mondelli, V. (2016). Brain microglia in psychiatric disorders. Lancet psychiatry, 0(0), 587-597. https://doi.org/10.1016/S2215-0366(17)30101-3
Mondelli, Valeria ; Vernon, Anthony C ; Turkheimer, Federico ; Dazzan, Paola ; Pariante, Carmine M ; Frost, JL ; Schafer, DP ; Banati, RB ; Newcombe, J ; Gunn, RN ; al., et ; Tang, Y ; Le, W ; Estes, ML ; McAllister, AK ; Ransohoff, RM ; Davalos, D ; Grutzendler, J ; Yang, G ; al., et ; Peferoen, LA ; Vogel, DY ; Ummenthum, K ; al., et ; Norden, DM ; Trojanowski, PJ ; Villanueva, E ; Navarro, E ; Godbout, JP ; Kreisel, T ; Frank, MG ; Licht, T ; al., et ; Wachholz, S ; Eßlinger, M ; Plümper, J ; Manitz, MP ; Juckel, G ; Friebe, A ; Trépanier, MO ; Hopperton, KE ; Mizrahi, R ; Mechawar, N ; Bazinet, RP ; Torres-Platas, SG ; Cruceanu, C ; Chen, GG ; Turecki, G ; Mechawar, N ; Steiner, J ; Bielau, H ; Brisch, R ; al., et ; Schnieder, TP ; Trencevska, I ; Rosoklija, G ; al., et ; Fillman, SG ; Cloonan, N ; Catts, VS ; al., et ; Rupprecht, R ; Papadopoulos, V ; Rammes, G ; al., et ; Qiu, ZK ; Li, MS ; He, JL ; al., et ; Hannestad, J ; Gallezot, JD ; Schafbauer, T ; al., et ; Israel, I ; Ohsiek, A ; Al-Momani, E ; al., et ; Mirzaei, N ; Tang, SP ; Ashworth, S ; al., et ; Gulyás, B ; Makkai, B ; Kása, P ; al., et ; Turkheimer, FE ; Rizzo, G ; Bloomfield, PS ; al., et ; Owen, DR ; Yeo, AJ ; Gunn, RN ; al., et ; Hannestad, J ; DellaGioia, N ; Gallezot, JD ; al., et ; Setiawan, E ; Wilson, AA ; Mizrahi, R ; al., et ; Su, L ; Faluyi, YO ; Hong, YT ; al., et ; Haarman, BC ; Lek, RF Riemersma-Van der ; Groot, JC de ; al., et ; Berckel, BN van ; Bossong, MG ; Boellaard, R ; al., et ; Doorduin, J ; Vries, EF de ; Willemsen, AT ; Groot, JC de ; Dierckx, RA ; Klein, HC ; Takano, A ; Arakawa, R ; Ito, H ; al., et ; Kenk, M ; Selvanathan, T ; Rao, N ; al., et ; Bloomfield, PS ; Selvaraj, S ; Veronese, M ; al., et ; Coughlin, JM ; Wang, Y ; Ambinder, EB ; al., et ; Doef, TF van der ; Witte, LD de ; Sutterland, AL ; al., et ; Hafizi, S ; Tseng, HH ; Rao, N ; al., et ; Holmes, SE ; Hinz, R ; Drake, RJ ; al., et ; Yaqub, M ; Berckel, BN van ; Schuitemaker, A ; al., et ; Turkheimer, FE ; Edison, P ; Pavese, N ; al., et ; Lockhart, A ; Davis, B ; Matthews, JC ; al., et ; Quarantelli, M ; Laule, C ; Vavasour, IM ; Kolind, SH ; al., et ; Pasternak, O ; Sochen, N ; Gur, Y ; Intrator, N ; Assaf, Y ; Andreasen, NC ; Ehrhardt, JC ; Swayze, VW ; al., et ; Supprian, T ; Hofmann, E ; Warmuth-Metz, M ; Franzek, E ; Becker, T ; Pfefferbaum, A ; Sullivan, EV ; Hedehus, M ; Moseley, M ; Lim, KO ; Mandl, RC ; Schnack, HG ; Luigjes, J ; al., et ; Mandl, RC ; Pasternak, O ; Cahn, W ; al., et ; Bagary, MS ; Symms, MR ; Barker, GJ ; Mutsatsa, SH ; Joyce, EM ; Ron, MA ; Foong, J ; Maier, M ; Barker, GJ ; Brocklehurst, S ; Miller, DH ; Ron, MA ; Foong, J ; Symms, MR ; Barker, GJ ; al., et ; Kubicki, M ; Park, H ; Westin, CF ; al., et ; Bagary, MS ; Foong, J ; Maier, M ; al., et ; Pasternak, O ; Westin, CF ; Bouix, S ; Pasternak, O ; Westin, CF ; Dahlben, B ; Bouix, S ; Kubicki, M ; Oestreich, LK ; Pasternak, O ; Shenton, ME ; al., et ; Amato, D ; Beasley, CL ; Hahn, MK ; Vernon, AC ; Vernon, AC ; Natesan, S ; Modo, M ; Kapur, S ; Mondelli, V ; Reininghaus, U ; Kempton, MJ ; Valmaggia, L ; al., et ; Baumeister, D ; Lightman, SL ; Pariante, CM ; Danese, A ; Moffitt, TE ; Pariante, CM ; Ambler, A ; Poulton, R ; Caspi, A ; Baumeister, D ; Akhtar, R ; Ciufolini, S ; Pariante, CM ; Mondelli, V ; Meyer, U ; Vernon, AC ; So, PW ; Lythgoe, DJ ; al., et ; Cotel, MC ; Lenartowicz, EM ; Natesan, S ; al., et ; Mondelli, V ; Anacker, C ; Vernon, AC ; al., et ; Calcia, MA ; Bonsall, DR ; Bloomfield, PS ; Selvaraj, S ; Barichello, T ; Howes, OD ; Burke, NN ; Fan, CY ; Trang, T ; McMahon, SB ; Russa, F La ; Bennett, DL ; Püntener, U ; Booth, SG ; Perry, VH ; Teeling, JL ; Hahn, YK ; Podhaizer, EM ; Farris, SP ; Miles, MF ; Hauser, KF ; Knapp, PE ; Notter, T ; Coughlin, JM ; Gschwind, T ; al., et ; Varga, B ; Markó, K ; Hádinger, N ; al., et ; Cattaneo, A ; Ferrari, C ; Uher, R ; al., et ; Mondelli, V ; Ciufolini, S ; Belvederi, Murri M ; al., et ; Sandiego, CM ; Gallezot, JD ; Pittman, B ; al., et ; Weber, MD ; Godbout, JP ; Sheridan, JF ; Raison, CL ; Rutherford, RE ; Woolwine, BJ ; al., et ; Möller, T ; Boddeke, HW ; O'Connor, JC ; Lawson, MA ; André, C ; al., et ; Hinwood, M ; Morandini, J ; Day, TA ; Walker, FR ; Möller, T ; Bard, F ; Bhattacharya, A ; al., et ; Pae, CU ; Marks, DM ; Han, C ; Patkar, AA ; Oya, K ; Kishi, T ; Iwata, N ; Baumeister, D ; Ciufolini, S ; Mondelli, V. / Brain microglia in psychiatric disorders. In: Lancet psychiatry. 2016 ; Vol. 0, No. 0. pp. 587-597.
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title = "Brain microglia in psychiatric disorders",
abstract = "SummaryThe role of immune activation in psychiatric disorders has attracted considerable attention over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the macrophages of the brain, are progressively becoming the main focus of the research in this field. In this Review, we assess the literature on microglia activation across different psychiatric disorders, including post-mortem and in-vivo studies in humans and experimental studies in animals. Although microglia activation has been noted in all types of psychiatric disorder, no association was seen with specific diagnostic categories. Furthermore, the findings from these studies highlight that not all psychiatric patients have microglial activation. Therefore, the cause of the neuroinflammation in these cohorts and its implications are unclear. We discuss psychosocial stress as one of the main factors determining microglial activation in patients with psychiatric disorders, and explore the relevance of these findings for future treatment strategies.",
author = "Valeria Mondelli and Vernon, {Anthony C} and Federico Turkheimer and Paola Dazzan and Pariante, {Carmine M} and JL Frost and DP Schafer and RB Banati and J Newcombe and RN Gunn and et al. and Y Tang and W Le and ML Estes and AK McAllister and RM Ransohoff and D Davalos and J Grutzendler and G Yang and et al. and LA Peferoen and DY Vogel and K Ummenthum and et al. and DM Norden and PJ Trojanowski and E Villanueva and E Navarro and JP Godbout and T Kreisel and MG Frank and T Licht and et al. and S Wachholz and M E{\ss}linger and J Pl{\"u}mper and MP Manitz and G Juckel and A Friebe and MO Tr{\'e}panier and KE Hopperton and R Mizrahi and N Mechawar and RP Bazinet and SG Torres-Platas and C Cruceanu and GG Chen and G Turecki and N Mechawar and J Steiner and H Bielau and R Brisch and et al. and TP Schnieder and I Trencevska and G Rosoklija and et al. and SG Fillman and N Cloonan and VS Catts and et al. and R Rupprecht and V Papadopoulos and G Rammes and et al. and ZK Qiu and MS Li and JL He and et al. and J Hannestad and JD Gallezot and T Schafbauer and et al. and I Israel and A Ohsiek and E Al-Momani and et al. and N Mirzaei and SP Tang and S Ashworth and et al. and B Guly{\'a}s and B Makkai and P K{\'a}sa and et al. and FE Turkheimer and G Rizzo and PS Bloomfield and et al. and DR Owen and AJ Yeo and RN Gunn and et al. and J Hannestad and N DellaGioia and JD Gallezot and et al. and E Setiawan and AA Wilson and R Mizrahi and et al. and L Su and YO Faluyi and YT Hong and et al. and BC Haarman and Lek, {RF Riemersma-Van der} and Groot, {JC de} and et al. and Berckel, {BN van} and MG Bossong and R Boellaard and et al. and J Doorduin and Vries, {EF de} and AT Willemsen and Groot, {JC de} and RA Dierckx and HC Klein and A Takano and R Arakawa and H Ito and et al. and M Kenk and T Selvanathan and N Rao and et al. and PS Bloomfield and S Selvaraj and M Veronese and et al. and JM Coughlin and Y Wang and EB Ambinder and et al. and Doef, {TF van der} and Witte, {LD de} and AL Sutterland and et al. and S Hafizi and HH Tseng and N Rao and et al. and SE Holmes and R Hinz and RJ Drake and et al. and M Yaqub and Berckel, {BN van} and A Schuitemaker and et al. and FE Turkheimer and P Edison and N Pavese and et al. and A Lockhart and B Davis and JC Matthews and et al. and M Quarantelli and C Laule and IM Vavasour and SH Kolind and et al. and O Pasternak and N Sochen and Y Gur and N Intrator and Y Assaf and NC Andreasen and JC Ehrhardt and VW Swayze and et al. and T Supprian and E Hofmann and M Warmuth-Metz and E Franzek and T Becker and A Pfefferbaum and EV Sullivan and M Hedehus and M Moseley and KO Lim and RC Mandl and HG Schnack and J Luigjes and et al. and RC Mandl and O Pasternak and W Cahn and et al. and MS Bagary and MR Symms and GJ Barker and SH Mutsatsa and EM Joyce and MA Ron and J Foong and M Maier and GJ Barker and S Brocklehurst and DH Miller and MA Ron and J Foong and MR Symms and GJ Barker and et al. and M Kubicki and H Park and CF Westin and et al. and MS Bagary and J Foong and M Maier and et al. and O Pasternak and CF Westin and S Bouix and O Pasternak and CF Westin and B Dahlben and S Bouix and M Kubicki and LK Oestreich and O Pasternak and ME Shenton and et al. and D Amato and CL Beasley and MK Hahn and AC Vernon and AC Vernon and S Natesan and M Modo and S Kapur and V Mondelli and U Reininghaus and MJ Kempton and L Valmaggia and et al. and D Baumeister and SL Lightman and CM Pariante and A Danese and TE Moffitt and CM Pariante and A Ambler and R Poulton and A Caspi and D Baumeister and R Akhtar and S Ciufolini and CM Pariante and V Mondelli and U Meyer and AC Vernon and PW So and DJ Lythgoe and et al. and MC Cotel and EM Lenartowicz and S Natesan and et al. and V Mondelli and C Anacker and AC Vernon and et al. and MA Calcia and DR Bonsall and PS Bloomfield and S Selvaraj and T Barichello and OD Howes and NN Burke and CY Fan and T Trang and SB McMahon and Russa, {F La} and DL Bennett and U P{\"u}ntener and SG Booth and VH Perry and JL Teeling and YK Hahn and EM Podhaizer and SP Farris and MF Miles and KF Hauser and PE Knapp and T Notter and JM Coughlin and T Gschwind and et al. and B Varga and K Mark{\'o} and N H{\'a}dinger and et al. and A Cattaneo and C Ferrari and R Uher and et al. and V Mondelli and S Ciufolini and Belvederi, {Murri M} and et al. and CM Sandiego and JD Gallezot and B Pittman and et al. and MD Weber and JP Godbout and JF Sheridan and CL Raison and RE Rutherford and BJ Woolwine and et al. and T M{\"o}ller and HW Boddeke and JC O'Connor and MA Lawson and C Andr{\'e} and et al. and M Hinwood and J Morandini and TA Day and FR Walker and T M{\"o}ller and F Bard and A Bhattacharya and et al. and CU Pae and DM Marks and C Han and AA Patkar and K Oya and T Kishi and N Iwata and D Baumeister and S Ciufolini and V Mondelli",
year = "2016",
doi = "10.1016/S2215-0366(17)30101-3",
language = "English",
volume = "0",
pages = "587--597",
journal = "Lancet psychiatry",
issn = "2215-0374",
publisher = "Elsevier Limited",
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}

Mondelli, V, Vernon, AC, Turkheimer, F, Dazzan, P, Pariante, CM, Frost, JL, Schafer, DP, Banati, RB, Newcombe, J, Gunn, RN, al., E, Tang, Y, Le, W, Estes, ML, McAllister, AK, Ransohoff, RM, Davalos, D, Grutzendler, J, Yang, G, al., E, Peferoen, LA, Vogel, DY, Ummenthum, K, al., E, Norden, DM, Trojanowski, PJ, Villanueva, E, Navarro, E, Godbout, JP, Kreisel, T, Frank, MG, Licht, T, al., E, Wachholz, S, Eßlinger, M, Plümper, J, Manitz, MP, Juckel, G, Friebe, A, Trépanier, MO, Hopperton, KE, Mizrahi, R, Mechawar, N, Bazinet, RP, Torres-Platas, SG, Cruceanu, C, Chen, GG, Turecki, G, Mechawar, N, Steiner, J, Bielau, H, Brisch, R, al., E, Schnieder, TP, Trencevska, I, Rosoklija, G, al., E, Fillman, SG, Cloonan, N, Catts, VS, al., E, Rupprecht, R, Papadopoulos, V, Rammes, G, al., E, Qiu, ZK, Li, MS, He, JL, al., E, Hannestad, J, Gallezot, JD, Schafbauer, T, al., E, Israel, I, Ohsiek, A, Al-Momani, E, al., E, Mirzaei, N, Tang, SP, Ashworth, S, al., E, Gulyás, B, Makkai, B, Kása, P, al., E, Turkheimer, FE, Rizzo, G, Bloomfield, PS, al., E, Owen, DR, Yeo, AJ, Gunn, RN, al., E, Hannestad, J, DellaGioia, N, Gallezot, JD, al., E, Setiawan, E, Wilson, AA, Mizrahi, R, al., E, Su, L, Faluyi, YO, Hong, YT, al., E, Haarman, BC, Lek, RFR-VD, Groot, JCD, al., E, Berckel, BNV, Bossong, MG, Boellaard, R, al., E, Doorduin, J, Vries, EFD, Willemsen, AT, Groot, JCD, Dierckx, RA, Klein, HC, Takano, A, Arakawa, R, Ito, H, al., E, Kenk, M, Selvanathan, T, Rao, N, al., E, Bloomfield, PS, Selvaraj, S, Veronese, M, al., E, Coughlin, JM, Wang, Y, Ambinder, EB, al., E, Doef, TFVD, Witte, LDD, Sutterland, AL, al., E, Hafizi, S, Tseng, HH, Rao, N, al., E, Holmes, SE, Hinz, R, Drake, RJ, al., E, Yaqub, M, Berckel, BNV, Schuitemaker, A, al., E, Turkheimer, FE, Edison, P, Pavese, N, al., E, Lockhart, A, Davis, B, Matthews, JC, al., E, Quarantelli, M, Laule, C, Vavasour, IM, Kolind, SH, al., E, Pasternak, O, Sochen, N, Gur, Y, Intrator, N, Assaf, Y, Andreasen, NC, Ehrhardt, JC, Swayze, VW, al., E, Supprian, T, Hofmann, E, Warmuth-Metz, M, Franzek, E, Becker, T, Pfefferbaum, A, Sullivan, EV, Hedehus, M, Moseley, M, Lim, KO, Mandl, RC, Schnack, HG, Luigjes, J, al., E, Mandl, RC, Pasternak, O, Cahn, W, al., E, Bagary, MS, Symms, MR, Barker, GJ, Mutsatsa, SH, Joyce, EM, Ron, MA, Foong, J, Maier, M, Barker, GJ, Brocklehurst, S, Miller, DH, Ron, MA, Foong, J, Symms, MR, Barker, GJ, al., E, Kubicki, M, Park, H, Westin, CF, al., E, Bagary, MS, Foong, J, Maier, M, al., E, Pasternak, O, Westin, CF, Bouix, S, Pasternak, O, Westin, CF, Dahlben, B, Bouix, S, Kubicki, M, Oestreich, LK, Pasternak, O, Shenton, ME, al., E, Amato, D, Beasley, CL, Hahn, MK, Vernon, AC, Vernon, AC, Natesan, S, Modo, M, Kapur, S, Mondelli, V, Reininghaus, U, Kempton, MJ, Valmaggia, L, al., E, Baumeister, D, Lightman, SL, Pariante, CM, Danese, A, Moffitt, TE, Pariante, CM, Ambler, A, Poulton, R, Caspi, A, Baumeister, D, Akhtar, R, Ciufolini, S, Pariante, CM, Mondelli, V, Meyer, U, Vernon, AC, So, PW, Lythgoe, DJ, al., E, Cotel, MC, Lenartowicz, EM, Natesan, S, al., E, Mondelli, V, Anacker, C, Vernon, AC, al., E, Calcia, MA, Bonsall, DR, Bloomfield, PS, Selvaraj, S, Barichello, T, Howes, OD, Burke, NN, Fan, CY, Trang, T, McMahon, SB, Russa, FL, Bennett, DL, Püntener, U, Booth, SG, Perry, VH, Teeling, JL, Hahn, YK, Podhaizer, EM, Farris, SP, Miles, MF, Hauser, KF, Knapp, PE, Notter, T, Coughlin, JM, Gschwind, T, al., E, Varga, B, Markó, K, Hádinger, N, al., E, Cattaneo, A, Ferrari, C, Uher, R, al., E, Mondelli, V, Ciufolini, S, Belvederi, MM, al., E, Sandiego, CM, Gallezot, JD, Pittman, B, al., E, Weber, MD, Godbout, JP, Sheridan, JF, Raison, CL, Rutherford, RE, Woolwine, BJ, al., E, Möller, T, Boddeke, HW, O'Connor, JC, Lawson, MA, André, C, al., E, Hinwood, M, Morandini, J, Day, TA, Walker, FR, Möller, T, Bard, F, Bhattacharya, A, al., E, Pae, CU, Marks, DM, Han, C, Patkar, AA, Oya, K, Kishi, T, Iwata, N, Baumeister, D, Ciufolini, S & Mondelli, V 2016, 'Brain microglia in psychiatric disorders' Lancet psychiatry, vol. 0, no. 0, pp. 587-597. https://doi.org/10.1016/S2215-0366(17)30101-3

Brain microglia in psychiatric disorders. / Mondelli, Valeria; Vernon, Anthony C; Turkheimer, Federico; Dazzan, Paola; Pariante, Carmine M; Frost, JL; Schafer, DP; Banati, RB; Newcombe, J; Gunn, RN; al., et; Tang, Y; Le, W; Estes, ML; McAllister, AK; Ransohoff, RM; Davalos, D; Grutzendler, J; Yang, G; al., et; Peferoen, LA; Vogel, DY; Ummenthum, K; al., et; Norden, DM; Trojanowski, PJ; Villanueva, E; Navarro, E; Godbout, JP; Kreisel, T; Frank, MG; Licht, T; al., et; Wachholz, S; Eßlinger, M; Plümper, J; Manitz, MP; Juckel, G; Friebe, A; Trépanier, MO; Hopperton, KE; Mizrahi, R; Mechawar, N; Bazinet, RP; Torres-Platas, SG; Cruceanu, C; Chen, GG; Turecki, G; Mechawar, N; Steiner, J; Bielau, H; Brisch, R; al., et; Schnieder, TP; Trencevska, I; Rosoklija, G; al., et; Fillman, SG; Cloonan, N; Catts, VS; al., et; Rupprecht, R; Papadopoulos, V; Rammes, G; al., et; Qiu, ZK; Li, MS; He, JL; al., et; Hannestad, J; Gallezot, JD; Schafbauer, T; al., et; Israel, I; Ohsiek, A; Al-Momani, E; al., et; Mirzaei, N; Tang, SP; Ashworth, S; al., et; Gulyás, B; Makkai, B; Kása, P; al., et; Turkheimer, FE; Rizzo, G; Bloomfield, PS; al., et; Owen, DR; Yeo, AJ; Gunn, RN; al., et; Hannestad, J; DellaGioia, N; Gallezot, JD; al., et; Setiawan, E; Wilson, AA; Mizrahi, R; al., et; Su, L; Faluyi, YO; Hong, YT; al., et; Haarman, BC; Lek, RF Riemersma-Van der; Groot, JC de; al., et; Berckel, BN van; Bossong, MG; Boellaard, R; al., et; Doorduin, J; Vries, EF de; Willemsen, AT; Groot, JC de; Dierckx, RA; Klein, HC; Takano, A; Arakawa, R; Ito, H; al., et; Kenk, M; Selvanathan, T; Rao, N; al., et; Bloomfield, PS; Selvaraj, S; Veronese, M; al., et; Coughlin, JM; Wang, Y; Ambinder, EB; al., et; Doef, TF van der; Witte, LD de; Sutterland, AL; al., et; Hafizi, S; Tseng, HH; Rao, N; al., et; Holmes, SE; Hinz, R; Drake, RJ; al., et; Yaqub, M; Berckel, BN van; Schuitemaker, A; al., et; Turkheimer, FE; Edison, P; Pavese, N; al., et; Lockhart, A; Davis, B; Matthews, JC; al., et; Quarantelli, M; Laule, C; Vavasour, IM; Kolind, SH; al., et; Pasternak, O; Sochen, N; Gur, Y; Intrator, N; Assaf, Y; Andreasen, NC; Ehrhardt, JC; Swayze, VW; al., et; Supprian, T; Hofmann, E; Warmuth-Metz, M; Franzek, E; Becker, T; Pfefferbaum, A; Sullivan, EV; Hedehus, M; Moseley, M; Lim, KO; Mandl, RC; Schnack, HG; Luigjes, J; al., et; Mandl, RC; Pasternak, O; Cahn, W; al., et; Bagary, MS; Symms, MR; Barker, GJ; Mutsatsa, SH; Joyce, EM; Ron, MA; Foong, J; Maier, M; Barker, GJ; Brocklehurst, S; Miller, DH; Ron, MA; Foong, J; Symms, MR; Barker, GJ; al., et; Kubicki, M; Park, H; Westin, CF; al., et; Bagary, MS; Foong, J; Maier, M; al., et; Pasternak, O; Westin, CF; Bouix, S; Pasternak, O; Westin, CF; Dahlben, B; Bouix, S; Kubicki, M; Oestreich, LK; Pasternak, O; Shenton, ME; al., et; Amato, D; Beasley, CL; Hahn, MK; Vernon, AC; Vernon, AC; Natesan, S; Modo, M; Kapur, S; Mondelli, V; Reininghaus, U; Kempton, MJ; Valmaggia, L; al., et; Baumeister, D; Lightman, SL; Pariante, CM; Danese, A; Moffitt, TE; Pariante, CM; Ambler, A; Poulton, R; Caspi, A; Baumeister, D; Akhtar, R; Ciufolini, S; Pariante, CM; Mondelli, V; Meyer, U; Vernon, AC; So, PW; Lythgoe, DJ; al., et; Cotel, MC; Lenartowicz, EM; Natesan, S; al., et; Mondelli, V; Anacker, C; Vernon, AC; al., et; Calcia, MA; Bonsall, DR; Bloomfield, PS; Selvaraj, S; Barichello, T; Howes, OD; Burke, NN; Fan, CY; Trang, T; McMahon, SB; Russa, F La; Bennett, DL; Püntener, U; Booth, SG; Perry, VH; Teeling, JL; Hahn, YK; Podhaizer, EM; Farris, SP; Miles, MF; Hauser, KF; Knapp, PE; Notter, T; Coughlin, JM; Gschwind, T; al., et; Varga, B; Markó, K; Hádinger, N; al., et; Cattaneo, A; Ferrari, C; Uher, R; al., et; Mondelli, V; Ciufolini, S; Belvederi, Murri M; al., et; Sandiego, CM; Gallezot, JD; Pittman, B; al., et; Weber, MD; Godbout, JP; Sheridan, JF; Raison, CL; Rutherford, RE; Woolwine, BJ; al., et; Möller, T; Boddeke, HW; O'Connor, JC; Lawson, MA; André, C; al., et; Hinwood, M; Morandini, J; Day, TA; Walker, FR; Möller, T; Bard, F; Bhattacharya, A; al., et; Pae, CU; Marks, DM; Han, C; Patkar, AA; Oya, K; Kishi, T; Iwata, N; Baumeister, D; Ciufolini, S; Mondelli, V.

In: Lancet psychiatry, Vol. 0, No. 0, 2016, p. 587-597.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Brain microglia in psychiatric disorders

AU - Mondelli, Valeria

AU - Vernon, Anthony C

AU - Turkheimer, Federico

AU - Dazzan, Paola

AU - Pariante, Carmine M

AU - Frost, JL

AU - Schafer, DP

AU - Banati, RB

AU - Newcombe, J

AU - Gunn, RN

AU - al., et

AU - Tang, Y

AU - Le, W

AU - Estes, ML

AU - McAllister, AK

AU - Ransohoff, RM

AU - Davalos, D

AU - Grutzendler, J

AU - Yang, G

AU - al., et

AU - Peferoen, LA

AU - Vogel, DY

AU - Ummenthum, K

AU - al., et

AU - Norden, DM

AU - Trojanowski, PJ

AU - Villanueva, E

AU - Navarro, E

AU - Godbout, JP

AU - Kreisel, T

AU - Frank, MG

AU - Licht, T

AU - al., et

AU - Wachholz, S

AU - Eßlinger, M

AU - Plümper, J

AU - Manitz, MP

AU - Juckel, G

AU - Friebe, A

AU - Trépanier, MO

AU - Hopperton, KE

AU - Mizrahi, R

AU - Mechawar, N

AU - Bazinet, RP

AU - Torres-Platas, SG

AU - Cruceanu, C

AU - Chen, GG

AU - Turecki, G

AU - Mechawar, N

AU - Steiner, J

AU - Bielau, H

AU - Brisch, R

AU - al., et

AU - Schnieder, TP

AU - Trencevska, I

AU - Rosoklija, G

AU - al., et

AU - Fillman, SG

AU - Cloonan, N

AU - Catts, VS

AU - al., et

AU - Rupprecht, R

AU - Papadopoulos, V

AU - Rammes, G

AU - al., et

AU - Qiu, ZK

AU - Li, MS

AU - He, JL

AU - al., et

AU - Hannestad, J

AU - Gallezot, JD

AU - Schafbauer, T

AU - al., et

AU - Israel, I

AU - Ohsiek, A

AU - Al-Momani, E

AU - al., et

AU - Mirzaei, N

AU - Tang, SP

AU - Ashworth, S

AU - al., et

AU - Gulyás, B

AU - Makkai, B

AU - Kása, P

AU - al., et

AU - Turkheimer, FE

AU - Rizzo, G

AU - Bloomfield, PS

AU - al., et

AU - Owen, DR

AU - Yeo, AJ

AU - Gunn, RN

AU - al., et

AU - Hannestad, J

AU - DellaGioia, N

AU - Gallezot, JD

AU - al., et

AU - Setiawan, E

AU - Wilson, AA

AU - Mizrahi, R

AU - al., et

AU - Su, L

AU - Faluyi, YO

AU - Hong, YT

AU - al., et

AU - Haarman, BC

AU - Lek, RF Riemersma-Van der

AU - Groot, JC de

AU - al., et

AU - Berckel, BN van

AU - Bossong, MG

AU - Boellaard, R

AU - al., et

AU - Doorduin, J

AU - Vries, EF de

AU - Willemsen, AT

AU - Groot, JC de

AU - Dierckx, RA

AU - Klein, HC

AU - Takano, A

AU - Arakawa, R

AU - Ito, H

AU - al., et

AU - Kenk, M

AU - Selvanathan, T

AU - Rao, N

AU - al., et

AU - Bloomfield, PS

AU - Selvaraj, S

AU - Veronese, M

AU - al., et

AU - Coughlin, JM

AU - Wang, Y

AU - Ambinder, EB

AU - al., et

AU - Doef, TF van der

AU - Witte, LD de

AU - Sutterland, AL

AU - al., et

AU - Hafizi, S

AU - Tseng, HH

AU - Rao, N

AU - al., et

AU - Holmes, SE

AU - Hinz, R

AU - Drake, RJ

AU - al., et

AU - Yaqub, M

AU - Berckel, BN van

AU - Schuitemaker, A

AU - al., et

AU - Turkheimer, FE

AU - Edison, P

AU - Pavese, N

AU - al., et

AU - Lockhart, A

AU - Davis, B

AU - Matthews, JC

AU - al., et

AU - Quarantelli, M

AU - Laule, C

AU - Vavasour, IM

AU - Kolind, SH

AU - al., et

AU - Pasternak, O

AU - Sochen, N

AU - Gur, Y

AU - Intrator, N

AU - Assaf, Y

AU - Andreasen, NC

AU - Ehrhardt, JC

AU - Swayze, VW

AU - al., et

AU - Supprian, T

AU - Hofmann, E

AU - Warmuth-Metz, M

AU - Franzek, E

AU - Becker, T

AU - Pfefferbaum, A

AU - Sullivan, EV

AU - Hedehus, M

AU - Moseley, M

AU - Lim, KO

AU - Mandl, RC

AU - Schnack, HG

AU - Luigjes, J

AU - al., et

AU - Mandl, RC

AU - Pasternak, O

AU - Cahn, W

AU - al., et

AU - Bagary, MS

AU - Symms, MR

AU - Barker, GJ

AU - Mutsatsa, SH

AU - Joyce, EM

AU - Ron, MA

AU - Foong, J

AU - Maier, M

AU - Barker, GJ

AU - Brocklehurst, S

AU - Miller, DH

AU - Ron, MA

AU - Foong, J

AU - Symms, MR

AU - Barker, GJ

AU - al., et

AU - Kubicki, M

AU - Park, H

AU - Westin, CF

AU - al., et

AU - Bagary, MS

AU - Foong, J

AU - Maier, M

AU - al., et

AU - Pasternak, O

AU - Westin, CF

AU - Bouix, S

AU - Pasternak, O

AU - Westin, CF

AU - Dahlben, B

AU - Bouix, S

AU - Kubicki, M

AU - Oestreich, LK

AU - Pasternak, O

AU - Shenton, ME

AU - al., et

AU - Amato, D

AU - Beasley, CL

AU - Hahn, MK

AU - Vernon, AC

AU - Vernon, AC

AU - Natesan, S

AU - Modo, M

AU - Kapur, S

AU - Mondelli, V

AU - Reininghaus, U

AU - Kempton, MJ

AU - Valmaggia, L

AU - al., et

AU - Baumeister, D

AU - Lightman, SL

AU - Pariante, CM

AU - Danese, A

AU - Moffitt, TE

AU - Pariante, CM

AU - Ambler, A

AU - Poulton, R

AU - Caspi, A

AU - Baumeister, D

AU - Akhtar, R

AU - Ciufolini, S

AU - Pariante, CM

AU - Mondelli, V

AU - Meyer, U

AU - Vernon, AC

AU - So, PW

AU - Lythgoe, DJ

AU - al., et

AU - Cotel, MC

AU - Lenartowicz, EM

AU - Natesan, S

AU - al., et

AU - Mondelli, V

AU - Anacker, C

AU - Vernon, AC

AU - al., et

AU - Calcia, MA

AU - Bonsall, DR

AU - Bloomfield, PS

AU - Selvaraj, S

AU - Barichello, T

AU - Howes, OD

AU - Burke, NN

AU - Fan, CY

AU - Trang, T

AU - McMahon, SB

AU - Russa, F La

AU - Bennett, DL

AU - Püntener, U

AU - Booth, SG

AU - Perry, VH

AU - Teeling, JL

AU - Hahn, YK

AU - Podhaizer, EM

AU - Farris, SP

AU - Miles, MF

AU - Hauser, KF

AU - Knapp, PE

AU - Notter, T

AU - Coughlin, JM

AU - Gschwind, T

AU - al., et

AU - Varga, B

AU - Markó, K

AU - Hádinger, N

AU - al., et

AU - Cattaneo, A

AU - Ferrari, C

AU - Uher, R

AU - al., et

AU - Mondelli, V

AU - Ciufolini, S

AU - Belvederi, Murri M

AU - al., et

AU - Sandiego, CM

AU - Gallezot, JD

AU - Pittman, B

AU - al., et

AU - Weber, MD

AU - Godbout, JP

AU - Sheridan, JF

AU - Raison, CL

AU - Rutherford, RE

AU - Woolwine, BJ

AU - al., et

AU - Möller, T

AU - Boddeke, HW

AU - O'Connor, JC

AU - Lawson, MA

AU - André, C

AU - al., et

AU - Hinwood, M

AU - Morandini, J

AU - Day, TA

AU - Walker, FR

AU - Möller, T

AU - Bard, F

AU - Bhattacharya, A

AU - al., et

AU - Pae, CU

AU - Marks, DM

AU - Han, C

AU - Patkar, AA

AU - Oya, K

AU - Kishi, T

AU - Iwata, N

AU - Baumeister, D

AU - Ciufolini, S

AU - Mondelli, V

PY - 2016

Y1 - 2016

N2 - SummaryThe role of immune activation in psychiatric disorders has attracted considerable attention over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the macrophages of the brain, are progressively becoming the main focus of the research in this field. In this Review, we assess the literature on microglia activation across different psychiatric disorders, including post-mortem and in-vivo studies in humans and experimental studies in animals. Although microglia activation has been noted in all types of psychiatric disorder, no association was seen with specific diagnostic categories. Furthermore, the findings from these studies highlight that not all psychiatric patients have microglial activation. Therefore, the cause of the neuroinflammation in these cohorts and its implications are unclear. We discuss psychosocial stress as one of the main factors determining microglial activation in patients with psychiatric disorders, and explore the relevance of these findings for future treatment strategies.

AB - SummaryThe role of immune activation in psychiatric disorders has attracted considerable attention over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the macrophages of the brain, are progressively becoming the main focus of the research in this field. In this Review, we assess the literature on microglia activation across different psychiatric disorders, including post-mortem and in-vivo studies in humans and experimental studies in animals. Although microglia activation has been noted in all types of psychiatric disorder, no association was seen with specific diagnostic categories. Furthermore, the findings from these studies highlight that not all psychiatric patients have microglial activation. Therefore, the cause of the neuroinflammation in these cohorts and its implications are unclear. We discuss psychosocial stress as one of the main factors determining microglial activation in patients with psychiatric disorders, and explore the relevance of these findings for future treatment strategies.

U2 - 10.1016/S2215-0366(17)30101-3

DO - 10.1016/S2215-0366(17)30101-3

M3 - Article

VL - 0

SP - 587

EP - 597

JO - Lancet psychiatry

JF - Lancet psychiatry

SN - 2215-0374

IS - 0

ER -

Mondelli V, Vernon AC, Turkheimer F, Dazzan P, Pariante CM, Frost JL et al. Brain microglia in psychiatric disorders. Lancet psychiatry. 2016;0(0):587-597. https://doi.org/10.1016/S2215-0366(17)30101-3