Abstract

Obese individuals are characterized by altered brain reward responses to food. Despite the latest discovery of obesity-associated genes, the contribution of environmental and genetic factors to brain reward responsiveness to food remains largely unclear. Sixteen female monozygotic twin pairs with a mean BMI discordance of 3.96 ± 2.1 kg/m2 were selected from the Netherlands Twin Register to undergo functional MRI scanning while watching high- and low-calorie food and non-food pictures and during the anticipation and receipt of chocolate milk. In addition, appetite ratings, eating behavior and food intake were assessed using visual analog scales, validated questionnaires and an ad libitum lunch. In the overall group, visual and taste stimuli elicited significant activation in regions of interest (ROIs) implicated in reward, i.e. amygdala, insula, striatum and orbitofrontal cortex. However, when comparing leaner and heavier co-twins no statistically significant differences in ROI-activations were observed after family wise error correction. Heavier versus leaner co-twins reported higher feelings of hunger (P = 0.02), cravings for sweet food (P = 0.04), body dissatisfaction (P < 0.05) and a trend towards more emotional eating (P = 0.1), whereas caloric intake was not significantly different between groups (P = 0.3). Our results suggest that inherited rather than environmental factors are largely responsible for the obesity-related altered brain responsiveness to food. Future studies should elucidate the genetic variants underlying the susceptibility to reward dysfunction and obesity. Clinical Trial Registration Number: NCT02025595.

Original languageEnglish
Pages (from-to)718-727
Number of pages10
JournalBrain Imaging and Behavior
Volume12
Issue number3
DOIs
Publication statusPublished - Jun 2018

Cite this

@article{65d2e3feedf74120a186810d50a914a5,
title = "Brain reward responses to food stimuli among female monozygotic twins discordant for BMI",
abstract = "Obese individuals are characterized by altered brain reward responses to food. Despite the latest discovery of obesity-associated genes, the contribution of environmental and genetic factors to brain reward responsiveness to food remains largely unclear. Sixteen female monozygotic twin pairs with a mean BMI discordance of 3.96 ± 2.1 kg/m2 were selected from the Netherlands Twin Register to undergo functional MRI scanning while watching high- and low-calorie food and non-food pictures and during the anticipation and receipt of chocolate milk. In addition, appetite ratings, eating behavior and food intake were assessed using visual analog scales, validated questionnaires and an ad libitum lunch. In the overall group, visual and taste stimuli elicited significant activation in regions of interest (ROIs) implicated in reward, i.e. amygdala, insula, striatum and orbitofrontal cortex. However, when comparing leaner and heavier co-twins no statistically significant differences in ROI-activations were observed after family wise error correction. Heavier versus leaner co-twins reported higher feelings of hunger (P = 0.02), cravings for sweet food (P = 0.04), body dissatisfaction (P < 0.05) and a trend towards more emotional eating (P = 0.1), whereas caloric intake was not significantly different between groups (P = 0.3). Our results suggest that inherited rather than environmental factors are largely responsible for the obesity-related altered brain responsiveness to food. Future studies should elucidate the genetic variants underlying the susceptibility to reward dysfunction and obesity. Clinical Trial Registration Number: NCT02025595.",
keywords = "fMRI, Food, Genetic, Monozygotic, Obesity, Reward",
author = "Stieneke Doornweerd and {de Geus}, {Eco J.} and Frederik Barkhof and {van Bloemendaal}, Liselotte and Boomsma, {Dorret I.} and {van Dongen}, Jenny and Drent, {Madeleine L.} and Gonneke Willemsen and Veltman, {Dick J.} and IJzerman, {Richard G.}",
year = "2018",
month = "6",
doi = "10.1007/s11682-017-9711-1",
language = "English",
volume = "12",
pages = "718--727",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",
number = "3",

}

Brain reward responses to food stimuli among female monozygotic twins discordant for BMI. / Doornweerd, Stieneke; de Geus, Eco J.; Barkhof, Frederik; van Bloemendaal, Liselotte; Boomsma, Dorret I.; van Dongen, Jenny; Drent, Madeleine L.; Willemsen, Gonneke; Veltman, Dick J.; IJzerman, Richard G.

In: Brain Imaging and Behavior, Vol. 12, No. 3, 06.2018, p. 718-727.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Brain reward responses to food stimuli among female monozygotic twins discordant for BMI

AU - Doornweerd, Stieneke

AU - de Geus, Eco J.

AU - Barkhof, Frederik

AU - van Bloemendaal, Liselotte

AU - Boomsma, Dorret I.

AU - van Dongen, Jenny

AU - Drent, Madeleine L.

AU - Willemsen, Gonneke

AU - Veltman, Dick J.

AU - IJzerman, Richard G.

PY - 2018/6

Y1 - 2018/6

N2 - Obese individuals are characterized by altered brain reward responses to food. Despite the latest discovery of obesity-associated genes, the contribution of environmental and genetic factors to brain reward responsiveness to food remains largely unclear. Sixteen female monozygotic twin pairs with a mean BMI discordance of 3.96 ± 2.1 kg/m2 were selected from the Netherlands Twin Register to undergo functional MRI scanning while watching high- and low-calorie food and non-food pictures and during the anticipation and receipt of chocolate milk. In addition, appetite ratings, eating behavior and food intake were assessed using visual analog scales, validated questionnaires and an ad libitum lunch. In the overall group, visual and taste stimuli elicited significant activation in regions of interest (ROIs) implicated in reward, i.e. amygdala, insula, striatum and orbitofrontal cortex. However, when comparing leaner and heavier co-twins no statistically significant differences in ROI-activations were observed after family wise error correction. Heavier versus leaner co-twins reported higher feelings of hunger (P = 0.02), cravings for sweet food (P = 0.04), body dissatisfaction (P < 0.05) and a trend towards more emotional eating (P = 0.1), whereas caloric intake was not significantly different between groups (P = 0.3). Our results suggest that inherited rather than environmental factors are largely responsible for the obesity-related altered brain responsiveness to food. Future studies should elucidate the genetic variants underlying the susceptibility to reward dysfunction and obesity. Clinical Trial Registration Number: NCT02025595.

AB - Obese individuals are characterized by altered brain reward responses to food. Despite the latest discovery of obesity-associated genes, the contribution of environmental and genetic factors to brain reward responsiveness to food remains largely unclear. Sixteen female monozygotic twin pairs with a mean BMI discordance of 3.96 ± 2.1 kg/m2 were selected from the Netherlands Twin Register to undergo functional MRI scanning while watching high- and low-calorie food and non-food pictures and during the anticipation and receipt of chocolate milk. In addition, appetite ratings, eating behavior and food intake were assessed using visual analog scales, validated questionnaires and an ad libitum lunch. In the overall group, visual and taste stimuli elicited significant activation in regions of interest (ROIs) implicated in reward, i.e. amygdala, insula, striatum and orbitofrontal cortex. However, when comparing leaner and heavier co-twins no statistically significant differences in ROI-activations were observed after family wise error correction. Heavier versus leaner co-twins reported higher feelings of hunger (P = 0.02), cravings for sweet food (P = 0.04), body dissatisfaction (P < 0.05) and a trend towards more emotional eating (P = 0.1), whereas caloric intake was not significantly different between groups (P = 0.3). Our results suggest that inherited rather than environmental factors are largely responsible for the obesity-related altered brain responsiveness to food. Future studies should elucidate the genetic variants underlying the susceptibility to reward dysfunction and obesity. Clinical Trial Registration Number: NCT02025595.

KW - fMRI

KW - Food

KW - Genetic

KW - Monozygotic

KW - Obesity

KW - Reward

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U2 - 10.1007/s11682-017-9711-1

DO - 10.1007/s11682-017-9711-1

M3 - Article

VL - 12

SP - 718

EP - 727

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

SN - 1931-7557

IS - 3

ER -