Breaching multiple barriers: Leukocyte motility through venular walls and the interstitium

Sussan Nourshargh*, Peter L. Hordijk, Michael Sixt

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review


The shuttling of leukocytes between the bloodstream and interstitial tissues involves different locomotion strategies that are governed by locally presented soluble and cell-bound signals. Recent studies have furthered our understanding of the rapidly advancing field of leukocyte migration, particularly regarding cellular and subcellular events at the level of the venular wall. Furthermore, emerging cellular models are now addressing the transition from an adherent mode to a non-adherent state, incorporating mechanisms that support an efficient migratory profile of leukocytes in the interstitial tissue beyond the venular wall.

Original languageEnglish
Pages (from-to)366-378
Number of pages13
JournalNature Reviews Molecular Cell Biology
Issue number5
Publication statusPublished - May 2010

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