Breakpoint identification and smoothing of array comparative genomic hybridization data

Kees Jong, Elena Marchiori, Gerrit Meijer, A. V.D. Vaart, Bauke Ylstra

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Summary: We describe a tool, called aCGH-Smooth, for the automated identification of breakpoints and smoothing of microarray comparative genomic hybridization (array CGH) data. aCGH-Smooth is written in visual C++, has a user-friendly interface including a visualization of the results and user-defined parameters adapting the performance of data smoothing and breakpoint recognition. aCGH-Smooth can handle array-CGH data generated by all array-CGH platforms: BAC, PAC, cosmid, cDNA and oligo CGH arrays. The tool has been successfully applied to real-life data.

Original languageEnglish
Pages (from-to)3636-3637
Number of pages2
JournalBioinformatics
Volume20
Issue number18
DOIs
Publication statusPublished - 12 Dec 2004

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