Brief Report: Anal Cancer in the HIV-Positive Population: Slowly Declining Incidence After a Decade of cART

Olivier Richel, Ramon P Van Der Zee, Colette Smit, Henry J C De Vries, Jan M Prins

Research output: Contribution to journalArticleAcademicpeer-review


We surveyed trends in incidence (1995-2012) and risk factors for anal cancer in the Dutch HIV-positive population. After an initial increase with a peak incidence in 2005-2006 of 114 [95% confidence interval (CI): 74 to 169] in all HIV+ patients and 168 (95% CI: 103 to 259) in HIV+ men who have sex with men (MSM), a decline to 72 (95% CI: 43 to 113) and 100 (95% CI: 56 to 164), respectively, was seen in 2011-2012. Low nadir CD4, alcohol use, and smoking were significantly associated with anal cancer in MSM. In conclusion, anal cancer remains a serious problem in predominantly HIV+ MSM. However, it seems that incidence rates are leveling off.

Original languageEnglish
Pages (from-to)602-5
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number5
Publication statusPublished - 15 Aug 2015

Cite this