Carbohydrates in allergy: from disease to novel immunotherapies

B. C. Keumatio Doungstop, S. J. van Vliet, R. van Ree, E. C. de Jong, Y. van Kooyk*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Respiratory allergic disorders are a global public health problem that are responsible for substantial morbidity and healthcare expenditure. Despite the availability of allergen immunotherapy (AIT), its efficacy is suboptimal and regimens are lengthy, with a significant risk of potentially severe side effects. Studies on the recognition of allergens by immune cells through carbohydrate–lectin interactions, which play a crucial role in immune modulation and pathogenesis of allergy, have paved the way for improvements in AIT. We highlight innovative approaches for more effective and safer AIT, including the use of allergens conjugated to specific carbohydrates that bind to C-type lectins (CLRs) and sialic acid-binding immunoglobulin-type lectins (Siglecs) on immune cells to induce suppressive responses.
Original languageEnglish
JournalTrends in Immunology
Early online date2021
DOIs
Publication statusE-pub ahead of print - 2021

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