Abstract
OBJECTIVES: To describe cardiovascular disease (CVD) risk factors in adolescents and young adults with myelomeningocele (MMC) and to explore relationships with physical activity, aerobic fitness, and body fat.
DESIGN: Cross-sectional study.
SETTING: Outpatient clinic.
PARTICIPANTS: Adolescents and young adults (N=31) with MMC (58% men) age 16 through 30 years; 13 were ambulatory and 18 were nonambulatory.
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURES: We studied biologic and lifestyle-related CVD risk factors, including lipid and lipoprotein profiles, blood pressure, aerobic fitness (Vo(2)peak), body fat, daily physical activity, and smoking behavior. We considered subjects at increased CVD risk when 2 or more of the following risk factors clustered: systolic blood pressure, total serum cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and cigarette smoking. Relationships were studied using regression analyses.
RESULTS: Levels of TC, low-density lipoprotein cholesterol, and triglycerides were elevated in 29%, 38%, and 3% of the participants, respectively. HDL-C was reduced in 19%. Hypertension was found in 20%, and 19% were current cigarette smokers. Based on the clustering of risk factors, 42% of the participants were at increased CVD risk: 15% of ambulatory participants and 61% of nonambulatory participants (P=.03). Adjusted for sex and ambulatory status, participants with higher aerobic fitness tended to be more likely to have no CVD risk (odds ratio=13.0; P=.07). CVD risk was not associated to physical activity and body fat.
CONCLUSIONS: A large proportion of the study sample was at CVD risk, indicated by clustering of risk factors. Improving aerobic fitness in young adults with MMC may contribute in reducing CVD risk; this needs to be confirmed in future studies.
| Original language | English |
|---|---|
| Pages (from-to) | 2167-73 |
| Number of pages | 7 |
| Journal | Archives of Physical Medicine and Rehabilitation |
| Volume | 89 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2008 |
Cite this
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Cardiovascular disease risk factors and the relationships with physical activity, aerobic fitness, and body fat in adolescents and young adults with myelomeningocele. / Buffart, Laurien M; van den Berg-Emons, Rita J; Burdorf, Alex; Janssen, Wim G; Stam, Henk J; Roebroeck, Marij E.
In: Archives of Physical Medicine and Rehabilitation, Vol. 89, No. 11, 11.2008, p. 2167-73.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Cardiovascular disease risk factors and the relationships with physical activity, aerobic fitness, and body fat in adolescents and young adults with myelomeningocele
AU - Buffart, Laurien M
AU - van den Berg-Emons, Rita J
AU - Burdorf, Alex
AU - Janssen, Wim G
AU - Stam, Henk J
AU - Roebroeck, Marij E
PY - 2008/11
Y1 - 2008/11
N2 - OBJECTIVES: To describe cardiovascular disease (CVD) risk factors in adolescents and young adults with myelomeningocele (MMC) and to explore relationships with physical activity, aerobic fitness, and body fat.DESIGN: Cross-sectional study.SETTING: Outpatient clinic.PARTICIPANTS: Adolescents and young adults (N=31) with MMC (58% men) age 16 through 30 years; 13 were ambulatory and 18 were nonambulatory.INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: We studied biologic and lifestyle-related CVD risk factors, including lipid and lipoprotein profiles, blood pressure, aerobic fitness (Vo(2)peak), body fat, daily physical activity, and smoking behavior. We considered subjects at increased CVD risk when 2 or more of the following risk factors clustered: systolic blood pressure, total serum cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and cigarette smoking. Relationships were studied using regression analyses.RESULTS: Levels of TC, low-density lipoprotein cholesterol, and triglycerides were elevated in 29%, 38%, and 3% of the participants, respectively. HDL-C was reduced in 19%. Hypertension was found in 20%, and 19% were current cigarette smokers. Based on the clustering of risk factors, 42% of the participants were at increased CVD risk: 15% of ambulatory participants and 61% of nonambulatory participants (P=.03). Adjusted for sex and ambulatory status, participants with higher aerobic fitness tended to be more likely to have no CVD risk (odds ratio=13.0; P=.07). CVD risk was not associated to physical activity and body fat.CONCLUSIONS: A large proportion of the study sample was at CVD risk, indicated by clustering of risk factors. Improving aerobic fitness in young adults with MMC may contribute in reducing CVD risk; this needs to be confirmed in future studies.
AB - OBJECTIVES: To describe cardiovascular disease (CVD) risk factors in adolescents and young adults with myelomeningocele (MMC) and to explore relationships with physical activity, aerobic fitness, and body fat.DESIGN: Cross-sectional study.SETTING: Outpatient clinic.PARTICIPANTS: Adolescents and young adults (N=31) with MMC (58% men) age 16 through 30 years; 13 were ambulatory and 18 were nonambulatory.INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: We studied biologic and lifestyle-related CVD risk factors, including lipid and lipoprotein profiles, blood pressure, aerobic fitness (Vo(2)peak), body fat, daily physical activity, and smoking behavior. We considered subjects at increased CVD risk when 2 or more of the following risk factors clustered: systolic blood pressure, total serum cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and cigarette smoking. Relationships were studied using regression analyses.RESULTS: Levels of TC, low-density lipoprotein cholesterol, and triglycerides were elevated in 29%, 38%, and 3% of the participants, respectively. HDL-C was reduced in 19%. Hypertension was found in 20%, and 19% were current cigarette smokers. Based on the clustering of risk factors, 42% of the participants were at increased CVD risk: 15% of ambulatory participants and 61% of nonambulatory participants (P=.03). Adjusted for sex and ambulatory status, participants with higher aerobic fitness tended to be more likely to have no CVD risk (odds ratio=13.0; P=.07). CVD risk was not associated to physical activity and body fat.CONCLUSIONS: A large proportion of the study sample was at CVD risk, indicated by clustering of risk factors. Improving aerobic fitness in young adults with MMC may contribute in reducing CVD risk; this needs to be confirmed in future studies.
KW - Adiposity
KW - Adolescent
KW - Adult
KW - Cardiovascular Diseases/prevention & control
KW - Cross-Sectional Studies
KW - Exercise
KW - Female
KW - Humans
KW - Life Style
KW - Logistic Models
KW - Male
KW - Meningomyelocele/rehabilitation
KW - Mobility Limitation
KW - Netherlands
KW - Physical Fitness
KW - Risk Factors
KW - Spina Bifida Cystica/rehabilitation
U2 - 10.1016/j.apmr.2008.04.015
DO - 10.1016/j.apmr.2008.04.015
M3 - Article
VL - 89
SP - 2167
EP - 2173
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
SN - 0003-9993
IS - 11
ER -