Catheter-Directed Thrombolysis for Acute Limb Ischemia in an Asian Population

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: The incidence of peripheral arterial occlusions in Asian populations is likely to increase exponentially in the present and future decades due to the adapted Western lifestyle in metropolitan Asian life, extended life expectancies, and high rates of smoking. The literature on thrombolytic treatment of peripheral arterial occlusions in Asian populations is limited. Therefore, we evaluated the thrombolysis results in a real-world contemporary Asian cohort of patients with peripheral arterial occlusions. Methods: Retrospective review of all electronic patient records of patients who underwent thrombolytic therapy for peripheral arterial occlusions between July 2011 and July 2016 was conducted. Outcomes were angiographic patency, clinical success, bleeding complications, amputation rates, and mortality rates. Results: In total, 82 patients (median age 66 years, range 34–95) underwent catheter-directed thrombolysis. Median treatment duration was 26 hr (3–209). Angiographic patency and clinical success rates were 64% and 66%, respectively. Bleeding complications occurred in 12% of patients of which 6% were major. Amputation-free rates were 81%, 67%, and 63% for 30 days, 6 months, and 1 year, respectively. In-hospital mortality was 6%. Conclusions: This study demonstrates that thrombolytic treatment of peripheral arterial occlusions in an Asian patient cohort yields comparable treatment success rates to Western cohorts; however, higher rates of bleeding complications are hazardous and remain a detrimental drawback of this treatment.
Original languageEnglish
Pages (from-to)246-250
Number of pages5
JournalAnnals of Vascular Surgery
Volume55
Early online date2018
DOIs
Publication statusPublished - 1 Feb 2019

Cite this

@article{5e1eaa27d2334ff8aa8b5de621f29342,
title = "Catheter-Directed Thrombolysis for Acute Limb Ischemia in an Asian Population",
abstract = "Background: The incidence of peripheral arterial occlusions in Asian populations is likely to increase exponentially in the present and future decades due to the adapted Western lifestyle in metropolitan Asian life, extended life expectancies, and high rates of smoking. The literature on thrombolytic treatment of peripheral arterial occlusions in Asian populations is limited. Therefore, we evaluated the thrombolysis results in a real-world contemporary Asian cohort of patients with peripheral arterial occlusions. Methods: Retrospective review of all electronic patient records of patients who underwent thrombolytic therapy for peripheral arterial occlusions between July 2011 and July 2016 was conducted. Outcomes were angiographic patency, clinical success, bleeding complications, amputation rates, and mortality rates. Results: In total, 82 patients (median age 66 years, range 34–95) underwent catheter-directed thrombolysis. Median treatment duration was 26 hr (3–209). Angiographic patency and clinical success rates were 64{\%} and 66{\%}, respectively. Bleeding complications occurred in 12{\%} of patients of which 6{\%} were major. Amputation-free rates were 81{\%}, 67{\%}, and 63{\%} for 30 days, 6 months, and 1 year, respectively. In-hospital mortality was 6{\%}. Conclusions: This study demonstrates that thrombolytic treatment of peripheral arterial occlusions in an Asian patient cohort yields comparable treatment success rates to Western cohorts; however, higher rates of bleeding complications are hazardous and remain a detrimental drawback of this treatment.",
author = "Ebben, {H. P.} and Yang, {H. T.} and Hoksbergen, {A. W. J.} and W. Wisselink and Ko, {P. J.} and Yeung, {K. K.}",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.avsg.2018.07.042",
language = "English",
volume = "55",
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journal = "Annals of Vascular Surgery",
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publisher = "Elsevier Inc.",

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Catheter-Directed Thrombolysis for Acute Limb Ischemia in an Asian Population. / Ebben, H. P.; Yang, H. T.; Hoksbergen, A. W. J.; Wisselink, W.; Ko, P. J.; Yeung, K. K.

In: Annals of Vascular Surgery, Vol. 55, 01.02.2019, p. 246-250.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Catheter-Directed Thrombolysis for Acute Limb Ischemia in an Asian Population

AU - Ebben, H. P.

AU - Yang, H. T.

AU - Hoksbergen, A. W. J.

AU - Wisselink, W.

AU - Ko, P. J.

AU - Yeung, K. K.

PY - 2019/2/1

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N2 - Background: The incidence of peripheral arterial occlusions in Asian populations is likely to increase exponentially in the present and future decades due to the adapted Western lifestyle in metropolitan Asian life, extended life expectancies, and high rates of smoking. The literature on thrombolytic treatment of peripheral arterial occlusions in Asian populations is limited. Therefore, we evaluated the thrombolysis results in a real-world contemporary Asian cohort of patients with peripheral arterial occlusions. Methods: Retrospective review of all electronic patient records of patients who underwent thrombolytic therapy for peripheral arterial occlusions between July 2011 and July 2016 was conducted. Outcomes were angiographic patency, clinical success, bleeding complications, amputation rates, and mortality rates. Results: In total, 82 patients (median age 66 years, range 34–95) underwent catheter-directed thrombolysis. Median treatment duration was 26 hr (3–209). Angiographic patency and clinical success rates were 64% and 66%, respectively. Bleeding complications occurred in 12% of patients of which 6% were major. Amputation-free rates were 81%, 67%, and 63% for 30 days, 6 months, and 1 year, respectively. In-hospital mortality was 6%. Conclusions: This study demonstrates that thrombolytic treatment of peripheral arterial occlusions in an Asian patient cohort yields comparable treatment success rates to Western cohorts; however, higher rates of bleeding complications are hazardous and remain a detrimental drawback of this treatment.

AB - Background: The incidence of peripheral arterial occlusions in Asian populations is likely to increase exponentially in the present and future decades due to the adapted Western lifestyle in metropolitan Asian life, extended life expectancies, and high rates of smoking. The literature on thrombolytic treatment of peripheral arterial occlusions in Asian populations is limited. Therefore, we evaluated the thrombolysis results in a real-world contemporary Asian cohort of patients with peripheral arterial occlusions. Methods: Retrospective review of all electronic patient records of patients who underwent thrombolytic therapy for peripheral arterial occlusions between July 2011 and July 2016 was conducted. Outcomes were angiographic patency, clinical success, bleeding complications, amputation rates, and mortality rates. Results: In total, 82 patients (median age 66 years, range 34–95) underwent catheter-directed thrombolysis. Median treatment duration was 26 hr (3–209). Angiographic patency and clinical success rates were 64% and 66%, respectively. Bleeding complications occurred in 12% of patients of which 6% were major. Amputation-free rates were 81%, 67%, and 63% for 30 days, 6 months, and 1 year, respectively. In-hospital mortality was 6%. Conclusions: This study demonstrates that thrombolytic treatment of peripheral arterial occlusions in an Asian patient cohort yields comparable treatment success rates to Western cohorts; however, higher rates of bleeding complications are hazardous and remain a detrimental drawback of this treatment.

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