Cellular factors involved in HIV-1 RNA transport

Truus E.M. Abbink*, Claire A. Williams, Andrew M.L. Lever

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

HIV-1 assembly and genomic RNA encapsidation have been intensively studied for many years. Many details of the interaction between the RNA packaging signal and the nucleocapsid (NC) domain of the structural Gag protein are now understood. However, there are still many unknowns regarding the spatial and temporal control of the RNA packaging process. It is generally assumed that cellular mRNAs are complexed with RNA-binding proteins during or shortly after transcription. These ribonucleoprotein complexes (RNPs) are subsequently trafficked out of the nucleus into the cytoplasm, where they can be translated at various locations, stored in stress granules during stress responses or destroyed by various RNA degradation machineries. It is assumed that the HIV-1 genomic RNA (gRNA) is also subject to these processes. The composition of the genomic RNP may thus determine the fate of the viral RNA. Indeed, it has been shown that altering the expression level of certain host proteins can affect HIV-1 translation, gRNA localization or particle assembly, implying that these proteins are important for efficient viral replication. Consequently, there is an increasing interest in targeting these host factors as an additional approach to antiviral treatment.

Original languageEnglish
Title of host publicationRecent Advances in Human Retroviruses
Subtitle of host publicationPrinciples of Replication and Pathogenesis: Advances in Retroviral Research
PublisherWorld Scientific Publishing Co. Pte Ltd
Pages171-210
Number of pages40
ISBN (Electronic)9789814295314
ISBN (Print)9814295302, 9789814295307
DOIs
Publication statusPublished - 1 Jan 2010

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