Ceramide analogues in apoptosis: A new strategy for anticancer drug development

Marco Macchia*, Simone Bertini, Stefano Fogli, Elisa Giovannetti, Filippo Minutolo, Simona Rapposelli, Romano Danesi

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A survey on the role played by ceramide within the sphingolmyelin pathway is here reported, taking into account its importance as an intracellular effector molecule in apoptosis. Recently, several analogs of ceramide, able to pass the cell membrane and then to induce apoptosis, have been developed as a new potential approach in anticancer therapy.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalFarmaco
Volume58
Issue number3
DOIs
Publication statusPublished - 1 Mar 2003

Cite this

Macchia, M., Bertini, S., Fogli, S., Giovannetti, E., Minutolo, F., Rapposelli, S., & Danesi, R. (2003). Ceramide analogues in apoptosis: A new strategy for anticancer drug development. Farmaco, 58(3), 205-211. https://doi.org/10.1016/S0014-827X(03)00015-6