Abstract

White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease. WMHs are also frequently observed in patients with familial and sporadic Alzheimer's disease, often with a particular posterior predominance. Whether amyloid and tau pathologies are linked to WMH occurrence is still debated. We examined whether cerebral amyloid and tau burden, reflected in cerebrospinal fluid amyloid-beta 1-42 (Aβ-42) and phosphorylated tau (p-tau), are related to WMH location in a cohort of 517 memory clinic patients. Two lesion mapping techniques were performed: voxel-based analyses and region of interest-based linear regression. Voxelwise associations were found between lower Aβ-42 and parieto-occipital periventricular WMHs. Regression analyses demonstrated that lower Aβ-42 correlated with larger WMH volumes in the splenium of the corpus callosum and posterior thalamic radiation, also after controlling for markers of vascular disease. P-tau was not consistently related to WMH occurrence. Our findings indicate that cerebral amyloid burden is associated with WMHs located in specific posterior white matter regions, possibly reflecting region-specific effects of amyloid pathology on the white matter.
Original languageEnglish
JournalNeurobiology of Aging
DOIs
Publication statusPublished - 2019

Cite this

@article{6cfbb1ee0dc94a249ed849c6cb472b46,
title = "Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions",
abstract = "White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease. WMHs are also frequently observed in patients with familial and sporadic Alzheimer's disease, often with a particular posterior predominance. Whether amyloid and tau pathologies are linked to WMH occurrence is still debated. We examined whether cerebral amyloid and tau burden, reflected in cerebrospinal fluid amyloid-beta 1-42 (Aβ-42) and phosphorylated tau (p-tau), are related to WMH location in a cohort of 517 memory clinic patients. Two lesion mapping techniques were performed: voxel-based analyses and region of interest-based linear regression. Voxelwise associations were found between lower Aβ-42 and parieto-occipital periventricular WMHs. Regression analyses demonstrated that lower Aβ-42 correlated with larger WMH volumes in the splenium of the corpus callosum and posterior thalamic radiation, also after controlling for markers of vascular disease. P-tau was not consistently related to WMH occurrence. Our findings indicate that cerebral amyloid burden is associated with WMHs located in specific posterior white matter regions, possibly reflecting region-specific effects of amyloid pathology on the white matter.",
author = "{TRACE-VCI study group} and Weaver, {Nick A.} and Thomas Doeven and Frederik Barkhof and Biesbroek, {J. Matthijs} and Groeneveld, {Onno N.} and Kuijf, {Hugo J.} and Prins, {Niels D.} and Philip Scheltens and Teunissen, {Charlotte E.} and {van der Flier}, {Wiesje M.} and Biessels, {Geert Jan}",
year = "2019",
doi = "10.1016/j.neurobiolaging.2019.08.001",
language = "English",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions. / TRACE-VCI study group.

In: Neurobiology of Aging, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions

AU - TRACE-VCI study group

AU - Weaver, Nick A.

AU - Doeven, Thomas

AU - Barkhof, Frederik

AU - Biesbroek, J. Matthijs

AU - Groeneveld, Onno N.

AU - Kuijf, Hugo J.

AU - Prins, Niels D.

AU - Scheltens, Philip

AU - Teunissen, Charlotte E.

AU - van der Flier, Wiesje M.

AU - Biessels, Geert Jan

PY - 2019

Y1 - 2019

N2 - White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease. WMHs are also frequently observed in patients with familial and sporadic Alzheimer's disease, often with a particular posterior predominance. Whether amyloid and tau pathologies are linked to WMH occurrence is still debated. We examined whether cerebral amyloid and tau burden, reflected in cerebrospinal fluid amyloid-beta 1-42 (Aβ-42) and phosphorylated tau (p-tau), are related to WMH location in a cohort of 517 memory clinic patients. Two lesion mapping techniques were performed: voxel-based analyses and region of interest-based linear regression. Voxelwise associations were found between lower Aβ-42 and parieto-occipital periventricular WMHs. Regression analyses demonstrated that lower Aβ-42 correlated with larger WMH volumes in the splenium of the corpus callosum and posterior thalamic radiation, also after controlling for markers of vascular disease. P-tau was not consistently related to WMH occurrence. Our findings indicate that cerebral amyloid burden is associated with WMHs located in specific posterior white matter regions, possibly reflecting region-specific effects of amyloid pathology on the white matter.

AB - White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease. WMHs are also frequently observed in patients with familial and sporadic Alzheimer's disease, often with a particular posterior predominance. Whether amyloid and tau pathologies are linked to WMH occurrence is still debated. We examined whether cerebral amyloid and tau burden, reflected in cerebrospinal fluid amyloid-beta 1-42 (Aβ-42) and phosphorylated tau (p-tau), are related to WMH location in a cohort of 517 memory clinic patients. Two lesion mapping techniques were performed: voxel-based analyses and region of interest-based linear regression. Voxelwise associations were found between lower Aβ-42 and parieto-occipital periventricular WMHs. Regression analyses demonstrated that lower Aβ-42 correlated with larger WMH volumes in the splenium of the corpus callosum and posterior thalamic radiation, also after controlling for markers of vascular disease. P-tau was not consistently related to WMH occurrence. Our findings indicate that cerebral amyloid burden is associated with WMHs located in specific posterior white matter regions, possibly reflecting region-specific effects of amyloid pathology on the white matter.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/31500909

U2 - 10.1016/j.neurobiolaging.2019.08.001

DO - 10.1016/j.neurobiolaging.2019.08.001

M3 - Article

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -