Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study

Anna E. Leeuwis, Lorna A. Smith, Andrew Melbourne, Alun D. Hughes, Marcus Richards, Niels D. Prins, Magdalena Sokolska, David Atkinson, Therese Tillin, Hans R. Jäger, Nish Chaturvedi, Wiesje M. van der Flier, Frederik Barkhof

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multiethnic cohort. Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 ± 5 years; 39%F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures. Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized ß [stß] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (stß = 0.14; p < 0.05 and stß = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups. Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline.
Original languageEnglish
Article number279
JournalFrontiers in Aging Neuroscience
Volume10
Issue numberSEP
DOIs
Publication statusPublished - 2018

Cite this

Leeuwis, Anna E. ; Smith, Lorna A. ; Melbourne, Andrew ; Hughes, Alun D. ; Richards, Marcus ; Prins, Niels D. ; Sokolska, Magdalena ; Atkinson, David ; Tillin, Therese ; Jäger, Hans R. ; Chaturvedi, Nish ; van der Flier, Wiesje M. ; Barkhof, Frederik. / Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort : The SABRE Study. In: Frontiers in Aging Neuroscience. 2018 ; Vol. 10, No. SEP.
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title = "Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study",
abstract = "Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multiethnic cohort. Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 ± 5 years; 39{\%}F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures. Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized {\ss} [st{\ss}] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (st{\ss} = 0.14; p < 0.05 and st{\ss} = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups. Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline.",
author = "Leeuwis, {Anna E.} and Smith, {Lorna A.} and Andrew Melbourne and Hughes, {Alun D.} and Marcus Richards and Prins, {Niels D.} and Magdalena Sokolska and David Atkinson and Therese Tillin and J{\"a}ger, {Hans R.} and Nish Chaturvedi and {van der Flier}, {Wiesje M.} and Frederik Barkhof",
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language = "English",
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Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort : The SABRE Study. / Leeuwis, Anna E.; Smith, Lorna A.; Melbourne, Andrew; Hughes, Alun D.; Richards, Marcus; Prins, Niels D.; Sokolska, Magdalena; Atkinson, David; Tillin, Therese; Jäger, Hans R.; Chaturvedi, Nish; van der Flier, Wiesje M.; Barkhof, Frederik.

In: Frontiers in Aging Neuroscience, Vol. 10, No. SEP, 279, 2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort

T2 - The SABRE Study

AU - Leeuwis, Anna E.

AU - Smith, Lorna A.

AU - Melbourne, Andrew

AU - Hughes, Alun D.

AU - Richards, Marcus

AU - Prins, Niels D.

AU - Sokolska, Magdalena

AU - Atkinson, David

AU - Tillin, Therese

AU - Jäger, Hans R.

AU - Chaturvedi, Nish

AU - van der Flier, Wiesje M.

AU - Barkhof, Frederik

PY - 2018

Y1 - 2018

N2 - Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multiethnic cohort. Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 ± 5 years; 39%F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures. Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized ß [stß] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (stß = 0.14; p < 0.05 and stß = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups. Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline.

AB - Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multiethnic cohort. Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 ± 5 years; 39%F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures. Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized ß [stß] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (stß = 0.14; p < 0.05 and stß = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups. Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30279656

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DO - 10.3389/fnagi.2018.00279

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JF - Frontiers in Aging Neuroscience

SN - 1663-4365

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