Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study

K P Braun, R M Dijkhuizen, R A de Graaf, K Nicolay, W P Vandertop, R H Gooskens, K A Tulleken

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the occurrence of cerebral ischemia in experimental hydrocephalus.

Original languageEnglish
Pages (from-to)295-8
Number of pages4
JournalBrain Research
Volume757
Issue number2
Publication statusPublished - 23 May 1997

Cite this

Braun, K. P., Dijkhuizen, R. M., de Graaf, R. A., Nicolay, K., Vandertop, W. P., Gooskens, R. H., & Tulleken, K. A. (1997). Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study. Brain Research, 757(2), 295-8.
Braun, K P ; Dijkhuizen, R M ; de Graaf, R A ; Nicolay, K ; Vandertop, W P ; Gooskens, R H ; Tulleken, K A. / Cerebral ischemia and white matter edema in experimental hydrocephalus : a combined in vivo MRI and MRS study. In: Brain Research. 1997 ; Vol. 757, No. 2. pp. 295-8.
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abstract = "T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the occurrence of cerebral ischemia in experimental hydrocephalus.",
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Braun, KP, Dijkhuizen, RM, de Graaf, RA, Nicolay, K, Vandertop, WP, Gooskens, RH & Tulleken, KA 1997, 'Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study' Brain Research, vol. 757, no. 2, pp. 295-8.

Cerebral ischemia and white matter edema in experimental hydrocephalus : a combined in vivo MRI and MRS study. / Braun, K P; Dijkhuizen, R M; de Graaf, R A; Nicolay, K; Vandertop, W P; Gooskens, R H; Tulleken, K A.

In: Brain Research, Vol. 757, No. 2, 23.05.1997, p. 295-8.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Cerebral ischemia and white matter edema in experimental hydrocephalus

T2 - a combined in vivo MRI and MRS study

AU - Braun, K P

AU - Dijkhuizen, R M

AU - de Graaf, R A

AU - Nicolay, K

AU - Vandertop, W P

AU - Gooskens, R H

AU - Tulleken, K A

PY - 1997/5/23

Y1 - 1997/5/23

N2 - T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the occurrence of cerebral ischemia in experimental hydrocephalus.

AB - T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the occurrence of cerebral ischemia in experimental hydrocephalus.

KW - Animals

KW - Brain/metabolism

KW - Brain Edema/etiology

KW - Brain Ischemia/etiology

KW - Energy Metabolism

KW - Hydrocephalus/complications

KW - Magnetic Resonance Imaging

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Phosphates/metabolism

KW - Phosphocreatine/metabolism

KW - Rats

KW - Rats, Wistar

M3 - Article

VL - 757

SP - 295

EP - 298

JO - Brain Research

JF - Brain Research

SN - 0006-8993

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ER -

Braun KP, Dijkhuizen RM, de Graaf RA, Nicolay K, Vandertop WP, Gooskens RH et al. Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study. Brain Research. 1997 May 23;757(2):295-8.