Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy

Knut Brockmann, Petra J.W. Pouwels, Peter Dechent, Kevin M. Flanigan, Jens Frahm, Folker Hanefeld

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalBrain and Development
Volume25
Issue number1
DOIs
Publication statusPublished - 1 Jan 2003
Externally publishedYes

Cite this

Brockmann, Knut ; Pouwels, Petra J.W. ; Dechent, Peter ; Flanigan, Kevin M. ; Frahm, Jens ; Hanefeld, Folker. / Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy. In: Brain and Development. 2003 ; Vol. 25, No. 1. pp. 45-50.
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Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy. / Brockmann, Knut; Pouwels, Petra J.W.; Dechent, Peter; Flanigan, Kevin M.; Frahm, Jens; Hanefeld, Folker.

In: Brain and Development, Vol. 25, No. 1, 01.01.2003, p. 45-50.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Pouwels, Petra J.W.

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AU - Frahm, Jens

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AB - Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter.

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