Cerebrovascular reserve capacity is impaired in patients with sickle cell disease

Erfan Nur, Yu-Sok Kim, Jasper Truijen, Eduard J van Beers, Shyrin C A T Davis, Dees P Brandjes, Bart J Biemond, Johannes J van Lieshout

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Sickle cell disease (SCD) is associated with a high incidence of ischemic stroke. SCD is characterized by hemolytic anemia, resulting in reduced nitric oxide-bioavailability, and by impaired cerebrovascular hemodynamics. Cerebrovascular CO2 responsiveness is nitric oxide dependent and has been related to an increased stroke risk in microvascular diseases. We questioned whether cerebrovascular CO2 responsiveness is impaired in SCD and related to hemolytic anemia. Transcranial Doppler-determined mean cerebral blood flow velocity (V(mean)), near-infrared spectroscopy-determined cerebral oxygenation, and end-tidal CO2 tension were monitored during normocapnia and hypercapnia in 23 patients and 16 control subjects. Cerebrovascular CO2 responsiveness was quantified as Delta% V(mean) and Deltamicromol/L cerebral oxyhemoglobin, deoxyhemoglobin, and total hemoglobin per mm Hg change in end-tidal CO2 tension. Both ways of measurements revealed lower cerebrovascular CO2 responsiveness in SCD patients versus controls (V(mean), 3.7, 3.1-4.7 vs 5.9, 4.6-6.7 Delta% V(mean) per mm Hg, P < .001; oxyhemoglobin, 0.36, 0.14-0.82 vs 0.78, 0.61-1.22 Deltamicromol/L per mm Hg, P = .025; deoxyhemoglobin, 0.35, 0.14-0.67 vs 0.58, 0.41-0.86 Deltamicromol/L per mm Hg, P = .033; total-hemoglobin, 0.13, 0.02-0.18 vs 0.23, 0.13-0.38 Deltamicromol/L per mm Hg, P = .038). Cerebrovascular CO2 responsiveness was not related to markers of hemolytic anemia. In SCD patients, impaired cerebrovascular CO2 responsiveness reflects reduced cerebrovascular reserve capacity, which may play a role in pathophysiology of stroke.

Original languageEnglish
Pages (from-to)3473-8
Number of pages6
JournalBlood
Volume114
Issue number16
DOIs
Publication statusPublished - 15 Oct 2009

Cite this

Nur, E., Kim, Y-S., Truijen, J., van Beers, E. J., Davis, S. C. A. T., Brandjes, D. P., ... van Lieshout, J. J. (2009). Cerebrovascular reserve capacity is impaired in patients with sickle cell disease. Blood, 114(16), 3473-8. https://doi.org/10.1182/blood-2009-05-223859