CGHcall: Calling aberrations for array CGH tumor profiles

Mark A. van de Wie, Kyung In Kim, Sjoerd J. Vosse, Wessel N. van Wieringen, Saskia M. Wilting, Bauke Ylstra

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Summary: CGHcall achieves high calling accuracy for array CGH data by effective use of breakpoint information from segmentation and by inclusion of several biological concepts that are ignored by existing algorithms. The algorithm is validated for simulated and verified real array CGH data. By incorporating more than three classes, CGHcall improves detection of single copy gains and amplifications. Moreover, it allows effective inclusion of chromosome arm information.

Original languageEnglish
Pages (from-to)892-894
Number of pages3
JournalBioinformatics
Volume23
Issue number7
DOIs
Publication statusPublished - 1 Apr 2007

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