Changes in resting-state directed connectivity in cortico-subcortical networks correlate with cognitive function in Parkinson's disease

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective The pathophysiological mechanisms underlying Parkinson's disease (PD)-related cognitive decline and conversion to PD dementia are poorly understood. In the healthy human brain, stable patterns of posterior-to-anterior cortical information flow have recently been demonstrated in the higher frequency bands using magnetoencephalography (MEG). In this study we estimated PD-related changes in information flow patterns, as well as the contribution of subcortical regions. Methods Resting-state MEG recordings were acquired in moderately advanced PD patients (n = 34; mean Hoehn and Yahr-stage 2.5) and healthy controls (n = 12). MEG signals were projected to both cortical and subcortical brain regions, following which we estimated the balance between incoming and outgoing information flow per region. Results In PD patients, compared to controls, preferential beta band information outflow was significantly higher for the basal ganglia and frontotemporal cortical regions, and significantly lower for parieto-occipital regions. In addition, in patients, low preferential information outflow from occipital regions correlated with poor global cognitive performance. Conclusion In the PD brain, a shift in balance towards more anterior-to-posterior beta band information flow takes place and is associated with poorer cognitive performance. Significance Our results indicate that a reversal of the physiological posterior-to-anterior information flow may be an important mechanism in PD-related cognitive decline.

Original languageEnglish
Pages (from-to)1319-1326
Number of pages8
JournalClinical Neurophysiology
Volume128
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Cite this

@article{d6ccaf0263f2497084a1db3fb71db263,
title = "Changes in resting-state directed connectivity in cortico-subcortical networks correlate with cognitive function in Parkinson's disease",
abstract = "Objective The pathophysiological mechanisms underlying Parkinson's disease (PD)-related cognitive decline and conversion to PD dementia are poorly understood. In the healthy human brain, stable patterns of posterior-to-anterior cortical information flow have recently been demonstrated in the higher frequency bands using magnetoencephalography (MEG). In this study we estimated PD-related changes in information flow patterns, as well as the contribution of subcortical regions. Methods Resting-state MEG recordings were acquired in moderately advanced PD patients (n = 34; mean Hoehn and Yahr-stage 2.5) and healthy controls (n = 12). MEG signals were projected to both cortical and subcortical brain regions, following which we estimated the balance between incoming and outgoing information flow per region. Results In PD patients, compared to controls, preferential beta band information outflow was significantly higher for the basal ganglia and frontotemporal cortical regions, and significantly lower for parieto-occipital regions. In addition, in patients, low preferential information outflow from occipital regions correlated with poor global cognitive performance. Conclusion In the PD brain, a shift in balance towards more anterior-to-posterior beta band information flow takes place and is associated with poorer cognitive performance. Significance Our results indicate that a reversal of the physiological posterior-to-anterior information flow may be an important mechanism in PD-related cognitive decline.",
keywords = "Atlas-based beamforming, Cognition, Directional connectivity, Magnetoencephalography (MEG), Parkinson's disease, Subcortical regions",
author = "Boon, {Lennard I.} and Arjan Hillebrand and {Olde Dubbelink}, {Kim T.E.} and Stam, {Cornelis J.} and Berendse, {Henk W.}",
year = "2017",
month = "7",
day = "1",
doi = "10.1016/j.clinph.2017.04.024",
language = "English",
volume = "128",
pages = "1319--1326",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "7",

}

TY - JOUR

T1 - Changes in resting-state directed connectivity in cortico-subcortical networks correlate with cognitive function in Parkinson's disease

AU - Boon, Lennard I.

AU - Hillebrand, Arjan

AU - Olde Dubbelink, Kim T.E.

AU - Stam, Cornelis J.

AU - Berendse, Henk W.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Objective The pathophysiological mechanisms underlying Parkinson's disease (PD)-related cognitive decline and conversion to PD dementia are poorly understood. In the healthy human brain, stable patterns of posterior-to-anterior cortical information flow have recently been demonstrated in the higher frequency bands using magnetoencephalography (MEG). In this study we estimated PD-related changes in information flow patterns, as well as the contribution of subcortical regions. Methods Resting-state MEG recordings were acquired in moderately advanced PD patients (n = 34; mean Hoehn and Yahr-stage 2.5) and healthy controls (n = 12). MEG signals were projected to both cortical and subcortical brain regions, following which we estimated the balance between incoming and outgoing information flow per region. Results In PD patients, compared to controls, preferential beta band information outflow was significantly higher for the basal ganglia and frontotemporal cortical regions, and significantly lower for parieto-occipital regions. In addition, in patients, low preferential information outflow from occipital regions correlated with poor global cognitive performance. Conclusion In the PD brain, a shift in balance towards more anterior-to-posterior beta band information flow takes place and is associated with poorer cognitive performance. Significance Our results indicate that a reversal of the physiological posterior-to-anterior information flow may be an important mechanism in PD-related cognitive decline.

AB - Objective The pathophysiological mechanisms underlying Parkinson's disease (PD)-related cognitive decline and conversion to PD dementia are poorly understood. In the healthy human brain, stable patterns of posterior-to-anterior cortical information flow have recently been demonstrated in the higher frequency bands using magnetoencephalography (MEG). In this study we estimated PD-related changes in information flow patterns, as well as the contribution of subcortical regions. Methods Resting-state MEG recordings were acquired in moderately advanced PD patients (n = 34; mean Hoehn and Yahr-stage 2.5) and healthy controls (n = 12). MEG signals were projected to both cortical and subcortical brain regions, following which we estimated the balance between incoming and outgoing information flow per region. Results In PD patients, compared to controls, preferential beta band information outflow was significantly higher for the basal ganglia and frontotemporal cortical regions, and significantly lower for parieto-occipital regions. In addition, in patients, low preferential information outflow from occipital regions correlated with poor global cognitive performance. Conclusion In the PD brain, a shift in balance towards more anterior-to-posterior beta band information flow takes place and is associated with poorer cognitive performance. Significance Our results indicate that a reversal of the physiological posterior-to-anterior information flow may be an important mechanism in PD-related cognitive decline.

KW - Atlas-based beamforming

KW - Cognition

KW - Directional connectivity

KW - Magnetoencephalography (MEG)

KW - Parkinson's disease

KW - Subcortical regions

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U2 - 10.1016/j.clinph.2017.04.024

DO - 10.1016/j.clinph.2017.04.024

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