Abstract

CONTEXT: Total 25-hydroxyvitamin D [25(OH)D] is mainly bound to vitamin D-binding protein (DBP). Bioavailable 25(OH)D consists of albumin-bound and free 25(OH)D and is available for metabolic processes. As sex steroids influence DBP, hormonal treatment (HT) in transgender people might affect DBP and consequently the available 25(OH)D. Total 25(OH)D might therefore not well represent bioavailable and free 25(OH)D.

OBJECTIVE: To investigate the effects of HT on DBP, and total, bioavailable, and free 25(OH)D, and to assess whether total 25(OH)D well represents bioavailable and free 25(OH)D.

DESIGN: A prospective study.

SETTING: A university hospital.

PARTICIPANTS: 29 transwomen and 30 transmen.

INTERVENTION: Estradiol and cyproterone acetate in transwomen, and testosterone in transmen.

MAIN OUTCOME MEASURES: DBP, total 25(OH)D, free 25(OH)D, and albumin were measured at baseline and after three months of HT, and deseasonalized total 25(OH)D and bioavailable 25(OH)D were calculated.

RESULTS: DBP changed with +5% (95%CI -0; +10%, p=0.06) in transwomen and with -3% (95%CI -9; +3%, p=0.34) in transmen. No significant changes were found in total 25(OH)D, free, and bioavailable 25(OH)D concentrations. Total 25(OH)D was well correlated with bioavailable (R2 0.75) and free (R2 0.76) 25(OH)D.

CONCLUSIONS: DBP tended to increase in transwomen, but did not change in transmen. HT did not influence free 25(OH)D, total 25(OH)D, and bioavailable 25(OH)D concentrations in transwomen and transmen. As total 25(OH)D represents bioavailable and free 25(OH)D well, HT in transgender people does not interfere with the assessment of vitamin D status.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
DOIs
Publication statusE-pub ahead of print - 20 Feb 2019

Cite this

@article{0b16457412d94a0d9bcde41a01e441af,
title = "Changes of vitamin D-binding protein, and total, bioavailable, and free 25-hydroxyvitamin D in transgender people",
abstract = "CONTEXT: Total 25-hydroxyvitamin D [25(OH)D] is mainly bound to vitamin D-binding protein (DBP). Bioavailable 25(OH)D consists of albumin-bound and free 25(OH)D and is available for metabolic processes. As sex steroids influence DBP, hormonal treatment (HT) in transgender people might affect DBP and consequently the available 25(OH)D. Total 25(OH)D might therefore not well represent bioavailable and free 25(OH)D.OBJECTIVE: To investigate the effects of HT on DBP, and total, bioavailable, and free 25(OH)D, and to assess whether total 25(OH)D well represents bioavailable and free 25(OH)D.DESIGN: A prospective study.SETTING: A university hospital.PARTICIPANTS: 29 transwomen and 30 transmen.INTERVENTION: Estradiol and cyproterone acetate in transwomen, and testosterone in transmen.MAIN OUTCOME MEASURES: DBP, total 25(OH)D, free 25(OH)D, and albumin were measured at baseline and after three months of HT, and deseasonalized total 25(OH)D and bioavailable 25(OH)D were calculated.RESULTS: DBP changed with +5{\%} (95{\%}CI -0; +10{\%}, p=0.06) in transwomen and with -3{\%} (95{\%}CI -9; +3{\%}, p=0.34) in transmen. No significant changes were found in total 25(OH)D, free, and bioavailable 25(OH)D concentrations. Total 25(OH)D was well correlated with bioavailable (R2 0.75) and free (R2 0.76) 25(OH)D.CONCLUSIONS: DBP tended to increase in transwomen, but did not change in transmen. HT did not influence free 25(OH)D, total 25(OH)D, and bioavailable 25(OH)D concentrations in transwomen and transmen. As total 25(OH)D represents bioavailable and free 25(OH)D well, HT in transgender people does not interfere with the assessment of vitamin D status.",
author = "Hailing Chen and Wiepjes, {Chantal M} and {van Schoor}, {Natasja M} and Heijboer, {Annemieke C} and {de Jongh}, {Renate T} and {den Heijer}, Martin and Paul Lips",
note = "Copyright {\circledC} 2019 Endocrine Society.",
year = "2019",
month = "2",
day = "20",
doi = "10.1210/jc.2018-02602",
language = "English",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",

}

TY - JOUR

T1 - Changes of vitamin D-binding protein, and total, bioavailable, and free 25-hydroxyvitamin D in transgender people

AU - Chen, Hailing

AU - Wiepjes, Chantal M

AU - van Schoor, Natasja M

AU - Heijboer, Annemieke C

AU - de Jongh, Renate T

AU - den Heijer, Martin

AU - Lips, Paul

N1 - Copyright © 2019 Endocrine Society.

PY - 2019/2/20

Y1 - 2019/2/20

N2 - CONTEXT: Total 25-hydroxyvitamin D [25(OH)D] is mainly bound to vitamin D-binding protein (DBP). Bioavailable 25(OH)D consists of albumin-bound and free 25(OH)D and is available for metabolic processes. As sex steroids influence DBP, hormonal treatment (HT) in transgender people might affect DBP and consequently the available 25(OH)D. Total 25(OH)D might therefore not well represent bioavailable and free 25(OH)D.OBJECTIVE: To investigate the effects of HT on DBP, and total, bioavailable, and free 25(OH)D, and to assess whether total 25(OH)D well represents bioavailable and free 25(OH)D.DESIGN: A prospective study.SETTING: A university hospital.PARTICIPANTS: 29 transwomen and 30 transmen.INTERVENTION: Estradiol and cyproterone acetate in transwomen, and testosterone in transmen.MAIN OUTCOME MEASURES: DBP, total 25(OH)D, free 25(OH)D, and albumin were measured at baseline and after three months of HT, and deseasonalized total 25(OH)D and bioavailable 25(OH)D were calculated.RESULTS: DBP changed with +5% (95%CI -0; +10%, p=0.06) in transwomen and with -3% (95%CI -9; +3%, p=0.34) in transmen. No significant changes were found in total 25(OH)D, free, and bioavailable 25(OH)D concentrations. Total 25(OH)D was well correlated with bioavailable (R2 0.75) and free (R2 0.76) 25(OH)D.CONCLUSIONS: DBP tended to increase in transwomen, but did not change in transmen. HT did not influence free 25(OH)D, total 25(OH)D, and bioavailable 25(OH)D concentrations in transwomen and transmen. As total 25(OH)D represents bioavailable and free 25(OH)D well, HT in transgender people does not interfere with the assessment of vitamin D status.

AB - CONTEXT: Total 25-hydroxyvitamin D [25(OH)D] is mainly bound to vitamin D-binding protein (DBP). Bioavailable 25(OH)D consists of albumin-bound and free 25(OH)D and is available for metabolic processes. As sex steroids influence DBP, hormonal treatment (HT) in transgender people might affect DBP and consequently the available 25(OH)D. Total 25(OH)D might therefore not well represent bioavailable and free 25(OH)D.OBJECTIVE: To investigate the effects of HT on DBP, and total, bioavailable, and free 25(OH)D, and to assess whether total 25(OH)D well represents bioavailable and free 25(OH)D.DESIGN: A prospective study.SETTING: A university hospital.PARTICIPANTS: 29 transwomen and 30 transmen.INTERVENTION: Estradiol and cyproterone acetate in transwomen, and testosterone in transmen.MAIN OUTCOME MEASURES: DBP, total 25(OH)D, free 25(OH)D, and albumin were measured at baseline and after three months of HT, and deseasonalized total 25(OH)D and bioavailable 25(OH)D were calculated.RESULTS: DBP changed with +5% (95%CI -0; +10%, p=0.06) in transwomen and with -3% (95%CI -9; +3%, p=0.34) in transmen. No significant changes were found in total 25(OH)D, free, and bioavailable 25(OH)D concentrations. Total 25(OH)D was well correlated with bioavailable (R2 0.75) and free (R2 0.76) 25(OH)D.CONCLUSIONS: DBP tended to increase in transwomen, but did not change in transmen. HT did not influence free 25(OH)D, total 25(OH)D, and bioavailable 25(OH)D concentrations in transwomen and transmen. As total 25(OH)D represents bioavailable and free 25(OH)D well, HT in transgender people does not interfere with the assessment of vitamin D status.

U2 - 10.1210/jc.2018-02602

DO - 10.1210/jc.2018-02602

M3 - Article

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

ER -