TY - JOUR
T1 - Changes of vitamin D-binding protein, and total, bioavailable, and free 25-hydroxyvitamin D in transgender people
AU - Chen, Hailing
AU - Wiepjes, Chantal M
AU - van Schoor, Natasja M
AU - Heijboer, Annemieke C
AU - de Jongh, Renate T
AU - den Heijer, Martin
AU - Lips, Paul
PY - 2019/3/21
Y1 - 2019/3/21
N2 - Total 25-hydroxyvitamin D [25(OH)D] is mainly bound to vitamin D-binding protein (DBP). Bioavailable 25(OH)D consists of albumin-bound and free 25(OH)D and is available for metabolic processes. As sex steroids influence DBP, hormonal treatment (HT) in transgender people might affect DBP and consequently the available 25(OH)D. Total 25(OH)D might therefore not well represent bioavailable and free 25(OH)D. Objective: To investigate the effects of HT on DBP, and total, bioavailable, and free 25(OH)D, and to assess whether total 25(OH)D well represents bioavailable and free 25(OH)D. Design: A prospective study. Setting: A university hospital. Participants: Twenty-nine transwomen and 30 transmen. Intervention: Estradiol and cyproterone acetate in transwomen, and testosterone in transmen. Main Outcome Measures: DBP, total 25(OH)D, free 25(OH)D, and albumin were measured at baseline and after 3 months of HT, and deseasonalized total 25(OH)D and bioavailable 25(OH)D were calculated.
AB - Total 25-hydroxyvitamin D [25(OH)D] is mainly bound to vitamin D-binding protein (DBP). Bioavailable 25(OH)D consists of albumin-bound and free 25(OH)D and is available for metabolic processes. As sex steroids influence DBP, hormonal treatment (HT) in transgender people might affect DBP and consequently the available 25(OH)D. Total 25(OH)D might therefore not well represent bioavailable and free 25(OH)D. Objective: To investigate the effects of HT on DBP, and total, bioavailable, and free 25(OH)D, and to assess whether total 25(OH)D well represents bioavailable and free 25(OH)D. Design: A prospective study. Setting: A university hospital. Participants: Twenty-nine transwomen and 30 transmen. Intervention: Estradiol and cyproterone acetate in transwomen, and testosterone in transmen. Main Outcome Measures: DBP, total 25(OH)D, free 25(OH)D, and albumin were measured at baseline and after 3 months of HT, and deseasonalized total 25(OH)D and bioavailable 25(OH)D were calculated.
UR - http://www.scopus.com/inward/record.url?scp=85066472893&partnerID=8YFLogxK
U2 - 10.1210/jc.2018-02602
DO - 10.1210/jc.2018-02602
M3 - Article
C2 - 30785996
VL - 104
SP - 2728
EP - 2734
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 7
M1 - jcem_201802602
ER -