Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies

Susana Brun, Wissam Beaino, Laurent Kremer, Omar Taleb, Ayikoe Guy Mensah-Nyagan, Chanh D. Lam, Judith M. Greer, JérÔme de Seze, Elisabeth Trifilieff*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17+ cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJournal of Neuroimmunology
Volume278
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

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