TY - JOUR
T1 - Characterizing 1-year development of cervical cord atrophy across different MS phenotypes
T2 - A voxel-wise, multicentre analysis
AU - Valsasina, Paola
AU - Gobbi, Claudio
AU - Zecca, Chiara
AU - Rovira, Alex
AU - Sastre-Garriga, Jaume
AU - Kearney, Hugh
AU - Yiannakas, Marios
AU - Matthews, Lucy
AU - Palace, Jacqueline
AU - Gallo, Antonio
AU - Bisecco, Alvino
AU - Gass, Achim
AU - Eisele, Philipp
AU - Filippi, Massimo
AU - Rocca, Maria A.
AU - Barkhof, Frederik
AU - Ciccarelli, Olga
AU - de Stefano, Nicola
AU - Enzinger, Christian
AU - Gasperini, Claudio
AU - Kappos, Ludwig
AU - Vrenken, Hugo
AU - Yousry, Tarek
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Background: Spatio-temporal evolution of cord atrophy in multiple sclerosis (MS) has not been investigated yet. Objective: To evaluate voxel-wise distribution and 1-year changes of cervical cord atrophy in a multicentre MS cohort. Methods: Baseline and 1-year 3D T1-weighted cervical cord scans and clinical evaluations of 54 healthy controls (HC) and 113 MS patients (14 clinically isolated syndromes (CIS), 77 relapsing-remitting (RR), 22 progressive (P)) were used to investigate voxel-wise cord volume loss in patients versus HC, 1-year volume changes and clinical correlations (SPM12). Results: MS patients exhibited baseline cord atrophy versus HC at anterior and posterior/lateral C1/C2 and C4–C6 (p < 0.05, corrected). While CIS patients showed baseline volume increase at C4 versus HC (p < 0.001, uncorrected), RRMS exhibited posterior/lateral C1/C2 atrophy versus CIS, and PMS showed widespread cord atrophy versus RRMS (p < 0.05, corrected). At 1 year, 13 patients had clinically worsened. Cord atrophy progressed in MS, driven by RRMS, at posterior/lateral C2 and C3–C6 (p < 0.05, corrected). CIS patients showed no volume changes, while PMS showed circumscribed atrophy progression. Baseline cord atrophy at posterior/lateral C1/C2 and C3–C6 correlated with concomitant and 1-year disability (r = −0.40/–0.62, p < 0.05, corrected). Conclusions: Voxel-wise analysis characterized spinal cord neurodegeneration over 1 year across MS phenotypes and helped to explain baseline and 1-year disability.
AB - Background: Spatio-temporal evolution of cord atrophy in multiple sclerosis (MS) has not been investigated yet. Objective: To evaluate voxel-wise distribution and 1-year changes of cervical cord atrophy in a multicentre MS cohort. Methods: Baseline and 1-year 3D T1-weighted cervical cord scans and clinical evaluations of 54 healthy controls (HC) and 113 MS patients (14 clinically isolated syndromes (CIS), 77 relapsing-remitting (RR), 22 progressive (P)) were used to investigate voxel-wise cord volume loss in patients versus HC, 1-year volume changes and clinical correlations (SPM12). Results: MS patients exhibited baseline cord atrophy versus HC at anterior and posterior/lateral C1/C2 and C4–C6 (p < 0.05, corrected). While CIS patients showed baseline volume increase at C4 versus HC (p < 0.001, uncorrected), RRMS exhibited posterior/lateral C1/C2 atrophy versus CIS, and PMS showed widespread cord atrophy versus RRMS (p < 0.05, corrected). At 1 year, 13 patients had clinically worsened. Cord atrophy progressed in MS, driven by RRMS, at posterior/lateral C2 and C3–C6 (p < 0.05, corrected). CIS patients showed no volume changes, while PMS showed circumscribed atrophy progression. Baseline cord atrophy at posterior/lateral C1/C2 and C3–C6 correlated with concomitant and 1-year disability (r = −0.40/–0.62, p < 0.05, corrected). Conclusions: Voxel-wise analysis characterized spinal cord neurodegeneration over 1 year across MS phenotypes and helped to explain baseline and 1-year disability.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85116317017&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/34605323
U2 - 10.1177/13524585211045545
DO - 10.1177/13524585211045545
M3 - Article
C2 - 34605323
SN - 1352-4585
VL - 28
SP - 885
EP - 899
JO - Multiple Sclerosis
JF - Multiple Sclerosis
IS - 6
ER -