TY - JOUR
T1 - CHEK2 1100delC and male breast cancer in the Netherlands
AU - Wasielewski, Marijke
AU - Den Bakker, Michael A.
AU - Van Den Ouweland, Ans
AU - Meijer-Van Gelder, Marion E.
AU - Portengen, Henk
AU - Klijn, Jan G.M.
AU - Meijers-Heijboer, Hanne
AU - Foekens, John A.
AU - Schutte, Mieke
PY - 2009/7
Y1 - 2009/7
N2 - Mutations in the breast cancer susceptibility genes BRCA1, BRCA2, and CHEK2 are known risk factors for female breast cancer. Mutations in BRCA1 and BRCA2 also are associated with male breast cancer (MBC). Similarly, it had been suggested in the original CHEK2 identification report that the CHEK2 1100delC mutation confers an increased risk for MBC. Here, we have evaluated the risk of CHEK2 1100delC for MBC by genotyping CHEK2 1100delC in 23 familial and 71 unselected Dutch MBC cases. None of the 23 familial MBC cases carried the CHEK2 1100delC mutation. In contrast, CHEK2 1100delC was present in 3 of the 71 (4.2%) unselected MBC cases, which was significantly more prevalent than the 1.1% Dutch population frequency assessed in 1,692 individuals (P = 0.05, OR = 4.1, 95% CI 1.2-14.3). Our data suggest that, in the Netherlands, CHEK2 1100delC is associated with an increased risk for MBC.
AB - Mutations in the breast cancer susceptibility genes BRCA1, BRCA2, and CHEK2 are known risk factors for female breast cancer. Mutations in BRCA1 and BRCA2 also are associated with male breast cancer (MBC). Similarly, it had been suggested in the original CHEK2 identification report that the CHEK2 1100delC mutation confers an increased risk for MBC. Here, we have evaluated the risk of CHEK2 1100delC for MBC by genotyping CHEK2 1100delC in 23 familial and 71 unselected Dutch MBC cases. None of the 23 familial MBC cases carried the CHEK2 1100delC mutation. In contrast, CHEK2 1100delC was present in 3 of the 71 (4.2%) unselected MBC cases, which was significantly more prevalent than the 1.1% Dutch population frequency assessed in 1,692 individuals (P = 0.05, OR = 4.1, 95% CI 1.2-14.3). Our data suggest that, in the Netherlands, CHEK2 1100delC is associated with an increased risk for MBC.
KW - Cancer susceptibility
KW - CHEK2
KW - CHK2
KW - Male breast cancer
UR - http://www.scopus.com/inward/record.url?scp=67649211518&partnerID=8YFLogxK
U2 - 10.1007/s10549-008-0162-7
DO - 10.1007/s10549-008-0162-7
M3 - Article
C2 - 18759107
AN - SCOPUS:67649211518
VL - 116
SP - 397
EP - 400
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 2
ER -