Childhood adversity impacts on brain subcortical structures relevant to depression

Thomas Frodl, Deborah Janowitz, Lianne Schmaal, Leonardo Tozzi, Henrik Dobrowolny, Dan J. Stein, Dick J. Veltman, Katharina Wittfeld, Theo G.M. van Erp, Neda Jahanshad, Andrea Block, Katrin Hegenscheid, Henry Völzke, Jim Lagopoulos, Sean N. Hatton, Ian B. Hickie, Eva Maria Frey, Angela Carballedo, Samantha J. Brooks, Daniella Vuletic & 18 others Anne Uhlmann, Ilya M. Veer, Henrik Walter, Knut Schnell, Dominik Grotegerd, Volker Arolt, Harald Kugel, Elisabeth Schramm, Carsten Konrad, Bartosz Zurowski, Bernhard T. Baune, Nic J.A. van der Wee, Marie Jose van Tol, Brenda W.J.H. Penninx, Paul M. Thompson, Derrek P. Hibar, Udo Dannlowski, Hans J. Grabe

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression.

Original languageEnglish
Pages (from-to)58-65
Number of pages8
JournalJournal of Psychiatric Research
Volume86
DOIs
Publication statusPublished - 1 Mar 2017

Cite this

Frodl, Thomas ; Janowitz, Deborah ; Schmaal, Lianne ; Tozzi, Leonardo ; Dobrowolny, Henrik ; Stein, Dan J. ; Veltman, Dick J. ; Wittfeld, Katharina ; van Erp, Theo G.M. ; Jahanshad, Neda ; Block, Andrea ; Hegenscheid, Katrin ; Völzke, Henry ; Lagopoulos, Jim ; Hatton, Sean N. ; Hickie, Ian B. ; Frey, Eva Maria ; Carballedo, Angela ; Brooks, Samantha J. ; Vuletic, Daniella ; Uhlmann, Anne ; Veer, Ilya M. ; Walter, Henrik ; Schnell, Knut ; Grotegerd, Dominik ; Arolt, Volker ; Kugel, Harald ; Schramm, Elisabeth ; Konrad, Carsten ; Zurowski, Bartosz ; Baune, Bernhard T. ; van der Wee, Nic J.A. ; van Tol, Marie Jose ; Penninx, Brenda W.J.H. ; Thompson, Paul M. ; Hibar, Derrek P. ; Dannlowski, Udo ; Grabe, Hans J. / Childhood adversity impacts on brain subcortical structures relevant to depression. In: Journal of Psychiatric Research. 2017 ; Vol. 86. pp. 58-65.
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title = "Childhood adversity impacts on brain subcortical structures relevant to depression",
abstract = "Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression.",
keywords = "Caudate, Childhood adversity, Depression, ENIGMA, Hippocampus, MRI",
author = "Thomas Frodl and Deborah Janowitz and Lianne Schmaal and Leonardo Tozzi and Henrik Dobrowolny and Stein, {Dan J.} and Veltman, {Dick J.} and Katharina Wittfeld and {van Erp}, {Theo G.M.} and Neda Jahanshad and Andrea Block and Katrin Hegenscheid and Henry V{\"o}lzke and Jim Lagopoulos and Hatton, {Sean N.} and Hickie, {Ian B.} and Frey, {Eva Maria} and Angela Carballedo and Brooks, {Samantha J.} and Daniella Vuletic and Anne Uhlmann and Veer, {Ilya M.} and Henrik Walter and Knut Schnell and Dominik Grotegerd and Volker Arolt and Harald Kugel and Elisabeth Schramm and Carsten Konrad and Bartosz Zurowski and Baune, {Bernhard T.} and {van der Wee}, {Nic J.A.} and {van Tol}, {Marie Jose} and Penninx, {Brenda W.J.H.} and Thompson, {Paul M.} and Hibar, {Derrek P.} and Udo Dannlowski and Grabe, {Hans J.}",
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Frodl, T, Janowitz, D, Schmaal, L, Tozzi, L, Dobrowolny, H, Stein, DJ, Veltman, DJ, Wittfeld, K, van Erp, TGM, Jahanshad, N, Block, A, Hegenscheid, K, Völzke, H, Lagopoulos, J, Hatton, SN, Hickie, IB, Frey, EM, Carballedo, A, Brooks, SJ, Vuletic, D, Uhlmann, A, Veer, IM, Walter, H, Schnell, K, Grotegerd, D, Arolt, V, Kugel, H, Schramm, E, Konrad, C, Zurowski, B, Baune, BT, van der Wee, NJA, van Tol, MJ, Penninx, BWJH, Thompson, PM, Hibar, DP, Dannlowski, U & Grabe, HJ 2017, 'Childhood adversity impacts on brain subcortical structures relevant to depression' Journal of Psychiatric Research, vol. 86, pp. 58-65. https://doi.org/10.1016/j.jpsychires.2016.11.010

Childhood adversity impacts on brain subcortical structures relevant to depression. / Frodl, Thomas; Janowitz, Deborah; Schmaal, Lianne; Tozzi, Leonardo; Dobrowolny, Henrik; Stein, Dan J.; Veltman, Dick J.; Wittfeld, Katharina; van Erp, Theo G.M.; Jahanshad, Neda; Block, Andrea; Hegenscheid, Katrin; Völzke, Henry; Lagopoulos, Jim; Hatton, Sean N.; Hickie, Ian B.; Frey, Eva Maria; Carballedo, Angela; Brooks, Samantha J.; Vuletic, Daniella; Uhlmann, Anne; Veer, Ilya M.; Walter, Henrik; Schnell, Knut; Grotegerd, Dominik; Arolt, Volker; Kugel, Harald; Schramm, Elisabeth; Konrad, Carsten; Zurowski, Bartosz; Baune, Bernhard T.; van der Wee, Nic J.A.; van Tol, Marie Jose; Penninx, Brenda W.J.H.; Thompson, Paul M.; Hibar, Derrek P.; Dannlowski, Udo; Grabe, Hans J.

In: Journal of Psychiatric Research, Vol. 86, 01.03.2017, p. 58-65.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Childhood adversity impacts on brain subcortical structures relevant to depression

AU - Frodl, Thomas

AU - Janowitz, Deborah

AU - Schmaal, Lianne

AU - Tozzi, Leonardo

AU - Dobrowolny, Henrik

AU - Stein, Dan J.

AU - Veltman, Dick J.

AU - Wittfeld, Katharina

AU - van Erp, Theo G.M.

AU - Jahanshad, Neda

AU - Block, Andrea

AU - Hegenscheid, Katrin

AU - Völzke, Henry

AU - Lagopoulos, Jim

AU - Hatton, Sean N.

AU - Hickie, Ian B.

AU - Frey, Eva Maria

AU - Carballedo, Angela

AU - Brooks, Samantha J.

AU - Vuletic, Daniella

AU - Uhlmann, Anne

AU - Veer, Ilya M.

AU - Walter, Henrik

AU - Schnell, Knut

AU - Grotegerd, Dominik

AU - Arolt, Volker

AU - Kugel, Harald

AU - Schramm, Elisabeth

AU - Konrad, Carsten

AU - Zurowski, Bartosz

AU - Baune, Bernhard T.

AU - van der Wee, Nic J.A.

AU - van Tol, Marie Jose

AU - Penninx, Brenda W.J.H.

AU - Thompson, Paul M.

AU - Hibar, Derrek P.

AU - Dannlowski, Udo

AU - Grabe, Hans J.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression.

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KW - Caudate

KW - Childhood adversity

KW - Depression

KW - ENIGMA

KW - Hippocampus

KW - MRI

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U2 - 10.1016/j.jpsychires.2016.11.010

DO - 10.1016/j.jpsychires.2016.11.010

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