Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

Richard J. Bende, Febe Van Maldegem, Carel J.M. Van Noesel

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.

Original languageEnglish
Pages (from-to)1109-1123
Number of pages15
JournalHaematologica
Volume94
Issue number8
DOIs
Publication statusPublished - Aug 2009

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