Chronic obsessive-compulsive disorder: Prognostic factors

Lucas J.B. Van Oudheusden, Merijn Eikelenboom, Harold J.G.M. Van Megen, Henny A.D. Visser, Koen Schruers, Gert Jan Hendriks, Nic Van Der Wee, Adriaan W. Hoogendoorn, Patricia Van Oppen, Anton J.L.M. Van Balkom

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background The course of illness in obsessive-compulsive disorder (OCD) varies significantly between patients. Little is known about factors predicting a chronic course of illness. The aim of this study is to identify factors involved in inducing and in maintaining chronicity in OCD.Methods The present study is embedded within the Netherlands Obsessive Compulsive Disorder Association (NOCDA) study, an ongoing multicenter naturalistic cohort study designed to identify predictors of long-term course and outcome in OCD. For this study, 270 subjects with a current diagnosis of OCD were included. Chronicity status at 2-year follow-up was regressed on a selection of baseline predictors related to OCD, to comorbidity and to stress and support.Results Psychotrauma [odds ratio (OR) 1.98, confidence interval (CI) 1.22-3.22, p = 0.006], recent negative life events (OR 1.42, CI 1.01-2.01, p = 0.043), and presence of a partner (OR 0.28, CI 0.09-0.85, p = 0.025) influenced the risk of becoming chronic. Longer illness duration (OR 1.46, CI 1.08-1.96, p = 0.013) and higher illness severity (OR 1.09, CI 1.03-1.16, p = 0.003) increased the risk of remaining chronic.Conclusions External influences increase the risk of becoming chronic, whereas the factors involved in maintaining chronicity are illness-related. As the latter are potentially difficult to modify, treatment should be devoted to prevent chronicity from occurring in the first place. Therapeutic strategies aimed at alleviating stress and at boosting social support might aid in achieving this goal.

LanguageEnglish
Pages2213-2222
Number of pages10
JournalPsychological Medicine
Volume48
Issue number13
DOIs
Publication statusPublished - 1 Oct 2018

Cite this

Van Oudheusden, Lucas J.B. ; Eikelenboom, Merijn ; Van Megen, Harold J.G.M. ; Visser, Henny A.D. ; Schruers, Koen ; Hendriks, Gert Jan ; Van Der Wee, Nic ; Hoogendoorn, Adriaan W. ; Van Oppen, Patricia ; Van Balkom, Anton J.L.M. / Chronic obsessive-compulsive disorder : Prognostic factors. In: Psychological Medicine. 2018 ; Vol. 48, No. 13. pp. 2213-2222.
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title = "Chronic obsessive-compulsive disorder: Prognostic factors",
abstract = "Background The course of illness in obsessive-compulsive disorder (OCD) varies significantly between patients. Little is known about factors predicting a chronic course of illness. The aim of this study is to identify factors involved in inducing and in maintaining chronicity in OCD.Methods The present study is embedded within the Netherlands Obsessive Compulsive Disorder Association (NOCDA) study, an ongoing multicenter naturalistic cohort study designed to identify predictors of long-term course and outcome in OCD. For this study, 270 subjects with a current diagnosis of OCD were included. Chronicity status at 2-year follow-up was regressed on a selection of baseline predictors related to OCD, to comorbidity and to stress and support.Results Psychotrauma [odds ratio (OR) 1.98, confidence interval (CI) 1.22-3.22, p = 0.006], recent negative life events (OR 1.42, CI 1.01-2.01, p = 0.043), and presence of a partner (OR 0.28, CI 0.09-0.85, p = 0.025) influenced the risk of becoming chronic. Longer illness duration (OR 1.46, CI 1.08-1.96, p = 0.013) and higher illness severity (OR 1.09, CI 1.03-1.16, p = 0.003) increased the risk of remaining chronic.Conclusions External influences increase the risk of becoming chronic, whereas the factors involved in maintaining chronicity are illness-related. As the latter are potentially difficult to modify, treatment should be devoted to prevent chronicity from occurring in the first place. Therapeutic strategies aimed at alleviating stress and at boosting social support might aid in achieving this goal.",
keywords = "chronicity, course of illness, Obsessive-compulsive disorder",
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Chronic obsessive-compulsive disorder : Prognostic factors. / Van Oudheusden, Lucas J.B.; Eikelenboom, Merijn; Van Megen, Harold J.G.M.; Visser, Henny A.D.; Schruers, Koen; Hendriks, Gert Jan; Van Der Wee, Nic; Hoogendoorn, Adriaan W.; Van Oppen, Patricia; Van Balkom, Anton J.L.M.

In: Psychological Medicine, Vol. 48, No. 13, 01.10.2018, p. 2213-2222.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Chronic obsessive-compulsive disorder

T2 - Psychological Medicine

AU - Van Oudheusden, Lucas J.B.

AU - Eikelenboom, Merijn

AU - Van Megen, Harold J.G.M.

AU - Visser, Henny A.D.

AU - Schruers, Koen

AU - Hendriks, Gert Jan

AU - Van Der Wee, Nic

AU - Hoogendoorn, Adriaan W.

AU - Van Oppen, Patricia

AU - Van Balkom, Anton J.L.M.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background The course of illness in obsessive-compulsive disorder (OCD) varies significantly between patients. Little is known about factors predicting a chronic course of illness. The aim of this study is to identify factors involved in inducing and in maintaining chronicity in OCD.Methods The present study is embedded within the Netherlands Obsessive Compulsive Disorder Association (NOCDA) study, an ongoing multicenter naturalistic cohort study designed to identify predictors of long-term course and outcome in OCD. For this study, 270 subjects with a current diagnosis of OCD were included. Chronicity status at 2-year follow-up was regressed on a selection of baseline predictors related to OCD, to comorbidity and to stress and support.Results Psychotrauma [odds ratio (OR) 1.98, confidence interval (CI) 1.22-3.22, p = 0.006], recent negative life events (OR 1.42, CI 1.01-2.01, p = 0.043), and presence of a partner (OR 0.28, CI 0.09-0.85, p = 0.025) influenced the risk of becoming chronic. Longer illness duration (OR 1.46, CI 1.08-1.96, p = 0.013) and higher illness severity (OR 1.09, CI 1.03-1.16, p = 0.003) increased the risk of remaining chronic.Conclusions External influences increase the risk of becoming chronic, whereas the factors involved in maintaining chronicity are illness-related. As the latter are potentially difficult to modify, treatment should be devoted to prevent chronicity from occurring in the first place. Therapeutic strategies aimed at alleviating stress and at boosting social support might aid in achieving this goal.

AB - Background The course of illness in obsessive-compulsive disorder (OCD) varies significantly between patients. Little is known about factors predicting a chronic course of illness. The aim of this study is to identify factors involved in inducing and in maintaining chronicity in OCD.Methods The present study is embedded within the Netherlands Obsessive Compulsive Disorder Association (NOCDA) study, an ongoing multicenter naturalistic cohort study designed to identify predictors of long-term course and outcome in OCD. For this study, 270 subjects with a current diagnosis of OCD were included. Chronicity status at 2-year follow-up was regressed on a selection of baseline predictors related to OCD, to comorbidity and to stress and support.Results Psychotrauma [odds ratio (OR) 1.98, confidence interval (CI) 1.22-3.22, p = 0.006], recent negative life events (OR 1.42, CI 1.01-2.01, p = 0.043), and presence of a partner (OR 0.28, CI 0.09-0.85, p = 0.025) influenced the risk of becoming chronic. Longer illness duration (OR 1.46, CI 1.08-1.96, p = 0.013) and higher illness severity (OR 1.09, CI 1.03-1.16, p = 0.003) increased the risk of remaining chronic.Conclusions External influences increase the risk of becoming chronic, whereas the factors involved in maintaining chronicity are illness-related. As the latter are potentially difficult to modify, treatment should be devoted to prevent chronicity from occurring in the first place. Therapeutic strategies aimed at alleviating stress and at boosting social support might aid in achieving this goal.

KW - chronicity

KW - course of illness

KW - Obsessive-compulsive disorder

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