Circle of Willis variations in migraine patients with ischemic stroke

the Dutch acute Stroke Study (DUST) investigators

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine. Materials and Methods: Participants were recruited from the prospective Dutch acute Stroke Study. All participants underwent CT angiography on admission. Lifetime migraine history was assessed with a screening questionnaire and confirmed by an interview based on International Classification of Headache Disorders criteria. The CoW was assessed for incompleteness/hypoplasia (any segment <1 mm), for anterior cerebral artery asymmetry (difference > 1/3), and for posterior communicating artery (Pcom) dominance (Pcom–P1 difference > 1/3). Odds ratios with adjustments for age and sex (aOR) were calculated with logistic regression. Results: We included 646 participants with stroke, of whom 52 had a history of migraine. Of these, 45 (87%) had an incomplete or hypoplastic CoW versus 506 (85%) of the 594 participants without migraine (aOR: 1.47; 95% CI: 0.63–3.44). There were no differences between participants with and without migraine in variations of the anterior or posterior CoW, anterior cerebral artery asymmetry (aOR: 0.86; 95% CI: 0.43–1.74), or Pcom dominance (aOR: 0.64; 95% CI: 0.32–1.30). There were no differences in CoW variations between migraine patients with or without aura. Conclusion: We found no significant difference in the completeness of the CoW in acute stroke patients with migraine compared to those without.
Original languageEnglish
Article numbere01223
JournalBrain and Behavior
DOIs
Publication statusPublished - 2019

Cite this

the Dutch acute Stroke Study (DUST) investigators. / Circle of Willis variations in migraine patients with ischemic stroke. In: Brain and Behavior. 2019.
@article{887f1c79cfd143719eb2098ea12885de,
title = "Circle of Willis variations in migraine patients with ischemic stroke",
abstract = "Objectives: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine. Materials and Methods: Participants were recruited from the prospective Dutch acute Stroke Study. All participants underwent CT angiography on admission. Lifetime migraine history was assessed with a screening questionnaire and confirmed by an interview based on International Classification of Headache Disorders criteria. The CoW was assessed for incompleteness/hypoplasia (any segment <1 mm), for anterior cerebral artery asymmetry (difference > 1/3), and for posterior communicating artery (Pcom) dominance (Pcom–P1 difference > 1/3). Odds ratios with adjustments for age and sex (aOR) were calculated with logistic regression. Results: We included 646 participants with stroke, of whom 52 had a history of migraine. Of these, 45 (87{\%}) had an incomplete or hypoplastic CoW versus 506 (85{\%}) of the 594 participants without migraine (aOR: 1.47; 95{\%} CI: 0.63–3.44). There were no differences between participants with and without migraine in variations of the anterior or posterior CoW, anterior cerebral artery asymmetry (aOR: 0.86; 95{\%} CI: 0.43–1.74), or Pcom dominance (aOR: 0.64; 95{\%} CI: 0.32–1.30). There were no differences in CoW variations between migraine patients with or without aura. Conclusion: We found no significant difference in the completeness of the CoW in acute stroke patients with migraine compared to those without.",
author = "{the Dutch acute Stroke Study (DUST) investigators} and Hamming, {Arend M.} and {van Walderveen}, {Marianne A. A.} and Mulder, {Inge A.} and {van der Schaaf}, {Irene C.} and Kappelle, {L. Jaap} and Velthuis, {Birgitta K.} and Ferrari, {Michel D.} and Terwindt, {Gisela M.} and Visser, {Marieke C.} and Wouter Schonewille and Ale Algra and Wermer, {Marieke J. H.}",
year = "2019",
doi = "10.1002/brb3.1223",
language = "English",
journal = "Brain and Behavior",
issn = "2162-3279",
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Circle of Willis variations in migraine patients with ischemic stroke. / the Dutch acute Stroke Study (DUST) investigators.

In: Brain and Behavior, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Circle of Willis variations in migraine patients with ischemic stroke

AU - the Dutch acute Stroke Study (DUST) investigators

AU - Hamming, Arend M.

AU - van Walderveen, Marianne A. A.

AU - Mulder, Inge A.

AU - van der Schaaf, Irene C.

AU - Kappelle, L. Jaap

AU - Velthuis, Birgitta K.

AU - Ferrari, Michel D.

AU - Terwindt, Gisela M.

AU - Visser, Marieke C.

AU - Schonewille, Wouter

AU - Algra, Ale

AU - Wermer, Marieke J. H.

PY - 2019

Y1 - 2019

N2 - Objectives: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine. Materials and Methods: Participants were recruited from the prospective Dutch acute Stroke Study. All participants underwent CT angiography on admission. Lifetime migraine history was assessed with a screening questionnaire and confirmed by an interview based on International Classification of Headache Disorders criteria. The CoW was assessed for incompleteness/hypoplasia (any segment <1 mm), for anterior cerebral artery asymmetry (difference > 1/3), and for posterior communicating artery (Pcom) dominance (Pcom–P1 difference > 1/3). Odds ratios with adjustments for age and sex (aOR) were calculated with logistic regression. Results: We included 646 participants with stroke, of whom 52 had a history of migraine. Of these, 45 (87%) had an incomplete or hypoplastic CoW versus 506 (85%) of the 594 participants without migraine (aOR: 1.47; 95% CI: 0.63–3.44). There were no differences between participants with and without migraine in variations of the anterior or posterior CoW, anterior cerebral artery asymmetry (aOR: 0.86; 95% CI: 0.43–1.74), or Pcom dominance (aOR: 0.64; 95% CI: 0.32–1.30). There were no differences in CoW variations between migraine patients with or without aura. Conclusion: We found no significant difference in the completeness of the CoW in acute stroke patients with migraine compared to those without.

AB - Objectives: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine. Materials and Methods: Participants were recruited from the prospective Dutch acute Stroke Study. All participants underwent CT angiography on admission. Lifetime migraine history was assessed with a screening questionnaire and confirmed by an interview based on International Classification of Headache Disorders criteria. The CoW was assessed for incompleteness/hypoplasia (any segment <1 mm), for anterior cerebral artery asymmetry (difference > 1/3), and for posterior communicating artery (Pcom) dominance (Pcom–P1 difference > 1/3). Odds ratios with adjustments for age and sex (aOR) were calculated with logistic regression. Results: We included 646 participants with stroke, of whom 52 had a history of migraine. Of these, 45 (87%) had an incomplete or hypoplastic CoW versus 506 (85%) of the 594 participants without migraine (aOR: 1.47; 95% CI: 0.63–3.44). There were no differences between participants with and without migraine in variations of the anterior or posterior CoW, anterior cerebral artery asymmetry (aOR: 0.86; 95% CI: 0.43–1.74), or Pcom dominance (aOR: 0.64; 95% CI: 0.32–1.30). There were no differences in CoW variations between migraine patients with or without aura. Conclusion: We found no significant difference in the completeness of the CoW in acute stroke patients with migraine compared to those without.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061604183&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30772952

U2 - 10.1002/brb3.1223

DO - 10.1002/brb3.1223

M3 - Article

JO - Brain and Behavior

JF - Brain and Behavior

SN - 2162-3279

M1 - e01223

ER -