Circulating linoleic acid and alpha-linolenic acid and glucose metabolism: the Hoorn Study

Mieke Cabout, Marjan Alssema, Giel Nijpels, Coen D.A. Stehouwer, Peter L. Zock, Ingeborg A. Brouwer, Amany K. Elshorbagy, Helga Refsum, Jacqueline M. Dekker

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: Data on the relation between linoleic acid (LA) and alpha-linolenic acid (ALA) and type 2 diabetes mellitus (T2DM) risk are scarce and inconsistent. The aim of this study was to investigate the association of serum LA and ALA with fasting and 2 h post-load plasma glucose and glycated hemoglobin (HbA1c). Method: This study included 667 participants from third examination (2000) of the population-based Hoorn study in which individuals with glucose intolerance were overrepresented. Fatty acid profiles in serum total lipids were measured at baseline, in 2000. Diabetes risk markers were measured at baseline and follow-up in 2008. Linear regression models were used in cross-sectional and prospective analyses. Results: In cross-sectional analyses (n = 667), serum LA was inversely associated with plasma glucose, both in fasting conditions (B = −0.024 [−0.045, −0.002]) and 2 h after glucose tolerance test (B = −0.099 [−0.158, −0.039]), but not with HbA1c (B = 0.000 [−0.014, 0.013]), after adjustment for relevant factors. In prospective analyses (n = 257), serum LA was not associated with fasting (B = 0.003 [−0.019, 0.025]) or post-load glucose (B = −0.026 [−0.100, 0.049]). Furthermore, no significant associations were found between serum ALA and glucose metabolism in cross-sectional or prospective analyses. Conclusions: In this study, serum LA was inversely associated with fasting and post-load glucose in cross-sectional, but not in prospective analyses. Further studies are needed to elucidate the exact role of serum LA and ALA levels and dietary polyunsaturated fatty acids in glucose metabolism.

Original languageEnglish
Pages (from-to)2171-2180
Number of pages10
JournalEuropean Journal of Nutrition
Volume56
Issue number6
DOIs
Publication statusPublished - 1 Sep 2017

Cite this

Cabout, Mieke ; Alssema, Marjan ; Nijpels, Giel ; Stehouwer, Coen D.A. ; Zock, Peter L. ; Brouwer, Ingeborg A. ; Elshorbagy, Amany K. ; Refsum, Helga ; Dekker, Jacqueline M. / Circulating linoleic acid and alpha-linolenic acid and glucose metabolism : the Hoorn Study. In: European Journal of Nutrition. 2017 ; Vol. 56, No. 6. pp. 2171-2180.
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title = "Circulating linoleic acid and alpha-linolenic acid and glucose metabolism: the Hoorn Study",
abstract = "Purpose: Data on the relation between linoleic acid (LA) and alpha-linolenic acid (ALA) and type 2 diabetes mellitus (T2DM) risk are scarce and inconsistent. The aim of this study was to investigate the association of serum LA and ALA with fasting and 2 h post-load plasma glucose and glycated hemoglobin (HbA1c). Method: This study included 667 participants from third examination (2000) of the population-based Hoorn study in which individuals with glucose intolerance were overrepresented. Fatty acid profiles in serum total lipids were measured at baseline, in 2000. Diabetes risk markers were measured at baseline and follow-up in 2008. Linear regression models were used in cross-sectional and prospective analyses. Results: In cross-sectional analyses (n = 667), serum LA was inversely associated with plasma glucose, both in fasting conditions (B = −0.024 [−0.045, −0.002]) and 2 h after glucose tolerance test (B = −0.099 [−0.158, −0.039]), but not with HbA1c (B = 0.000 [−0.014, 0.013]), after adjustment for relevant factors. In prospective analyses (n = 257), serum LA was not associated with fasting (B = 0.003 [−0.019, 0.025]) or post-load glucose (B = −0.026 [−0.100, 0.049]). Furthermore, no significant associations were found between serum ALA and glucose metabolism in cross-sectional or prospective analyses. Conclusions: In this study, serum LA was inversely associated with fasting and post-load glucose in cross-sectional, but not in prospective analyses. Further studies are needed to elucidate the exact role of serum LA and ALA levels and dietary polyunsaturated fatty acids in glucose metabolism.",
keywords = "Alpha-linolenic acid, Glucose, Hemoglobin A1c, Linoleic acid, Serum fatty acids, Type 2 diabetes",
author = "Mieke Cabout and Marjan Alssema and Giel Nijpels and Stehouwer, {Coen D.A.} and Zock, {Peter L.} and Brouwer, {Ingeborg A.} and Elshorbagy, {Amany K.} and Helga Refsum and Dekker, {Jacqueline M.}",
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Cabout, M, Alssema, M, Nijpels, G, Stehouwer, CDA, Zock, PL, Brouwer, IA, Elshorbagy, AK, Refsum, H & Dekker, JM 2017, 'Circulating linoleic acid and alpha-linolenic acid and glucose metabolism: the Hoorn Study' European Journal of Nutrition, vol. 56, no. 6, pp. 2171-2180. https://doi.org/10.1007/s00394-016-1261-6

Circulating linoleic acid and alpha-linolenic acid and glucose metabolism : the Hoorn Study. / Cabout, Mieke; Alssema, Marjan; Nijpels, Giel; Stehouwer, Coen D.A.; Zock, Peter L.; Brouwer, Ingeborg A.; Elshorbagy, Amany K.; Refsum, Helga; Dekker, Jacqueline M.

In: European Journal of Nutrition, Vol. 56, No. 6, 01.09.2017, p. 2171-2180.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Circulating linoleic acid and alpha-linolenic acid and glucose metabolism

T2 - the Hoorn Study

AU - Cabout, Mieke

AU - Alssema, Marjan

AU - Nijpels, Giel

AU - Stehouwer, Coen D.A.

AU - Zock, Peter L.

AU - Brouwer, Ingeborg A.

AU - Elshorbagy, Amany K.

AU - Refsum, Helga

AU - Dekker, Jacqueline M.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Purpose: Data on the relation between linoleic acid (LA) and alpha-linolenic acid (ALA) and type 2 diabetes mellitus (T2DM) risk are scarce and inconsistent. The aim of this study was to investigate the association of serum LA and ALA with fasting and 2 h post-load plasma glucose and glycated hemoglobin (HbA1c). Method: This study included 667 participants from third examination (2000) of the population-based Hoorn study in which individuals with glucose intolerance were overrepresented. Fatty acid profiles in serum total lipids were measured at baseline, in 2000. Diabetes risk markers were measured at baseline and follow-up in 2008. Linear regression models were used in cross-sectional and prospective analyses. Results: In cross-sectional analyses (n = 667), serum LA was inversely associated with plasma glucose, both in fasting conditions (B = −0.024 [−0.045, −0.002]) and 2 h after glucose tolerance test (B = −0.099 [−0.158, −0.039]), but not with HbA1c (B = 0.000 [−0.014, 0.013]), after adjustment for relevant factors. In prospective analyses (n = 257), serum LA was not associated with fasting (B = 0.003 [−0.019, 0.025]) or post-load glucose (B = −0.026 [−0.100, 0.049]). Furthermore, no significant associations were found between serum ALA and glucose metabolism in cross-sectional or prospective analyses. Conclusions: In this study, serum LA was inversely associated with fasting and post-load glucose in cross-sectional, but not in prospective analyses. Further studies are needed to elucidate the exact role of serum LA and ALA levels and dietary polyunsaturated fatty acids in glucose metabolism.

AB - Purpose: Data on the relation between linoleic acid (LA) and alpha-linolenic acid (ALA) and type 2 diabetes mellitus (T2DM) risk are scarce and inconsistent. The aim of this study was to investigate the association of serum LA and ALA with fasting and 2 h post-load plasma glucose and glycated hemoglobin (HbA1c). Method: This study included 667 participants from third examination (2000) of the population-based Hoorn study in which individuals with glucose intolerance were overrepresented. Fatty acid profiles in serum total lipids were measured at baseline, in 2000. Diabetes risk markers were measured at baseline and follow-up in 2008. Linear regression models were used in cross-sectional and prospective analyses. Results: In cross-sectional analyses (n = 667), serum LA was inversely associated with plasma glucose, both in fasting conditions (B = −0.024 [−0.045, −0.002]) and 2 h after glucose tolerance test (B = −0.099 [−0.158, −0.039]), but not with HbA1c (B = 0.000 [−0.014, 0.013]), after adjustment for relevant factors. In prospective analyses (n = 257), serum LA was not associated with fasting (B = 0.003 [−0.019, 0.025]) or post-load glucose (B = −0.026 [−0.100, 0.049]). Furthermore, no significant associations were found between serum ALA and glucose metabolism in cross-sectional or prospective analyses. Conclusions: In this study, serum LA was inversely associated with fasting and post-load glucose in cross-sectional, but not in prospective analyses. Further studies are needed to elucidate the exact role of serum LA and ALA levels and dietary polyunsaturated fatty acids in glucose metabolism.

KW - Alpha-linolenic acid

KW - Glucose

KW - Hemoglobin A1c

KW - Linoleic acid

KW - Serum fatty acids

KW - Type 2 diabetes

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U2 - 10.1007/s00394-016-1261-6

DO - 10.1007/s00394-016-1261-6

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EP - 2180

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

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ER -