Circulating metabolites are associated with brain atrophy and white matter hyperintensities

Francisca A. de Leeuw; Hata Karamujić-Čomić; Betty M. Tijms; Carel F. W. Peeters; Maartje I. Kester; Philip Scheltens; Shahzad Ahmad; Dina Vojinovic; Hieab H. H. Adams; Thomas Hankemeier; Daniel Bos; Aad van der Lugt; Meike W. Vernooij; M. Arfan Ikram; Najaf Amin; Frederik Barkhof; Charlotte E. Teunissen; Cornelia M. van Duijn; Wiesje M. van der Flier

doi:10.1002/alz.12180

Circulating metabolites are associated with brain atrophy and white matter hyperintensities

Francisca A. de Leeuw^*, Hata Karamujić-Čomić^*, Betty M. Tijms, Carel F. W. Peeters, Maartje I. Kester, Philip Scheltens, Shahzad Ahmad, Dina Vojinovic, Hieab H. H. Adams, Thomas Hankemeier, Daniel Bos, Aad van der Lugt, Meike W. Vernooij, M. Arfan Ikram, Najaf Amin, Frederik Barkhof, Charlotte E. Teunissen, Cornelia M. van Duijn, Wiesje M. van der Flier

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.

Original language	English
Journal	Alzheimer's and Dementia
Early online date	2020
DOIs	https://doi.org/10.1002/alz.12180
Publication status	E-pub ahead of print - 2020

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10.1002/alz.12180

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de Leeuw, F. A., Karamujić-Čomić, H., Tijms, B. M., Peeters, C. F. W., Kester, M. I., Scheltens, P., Ahmad, S., Vojinovic, D., Adams, H. H. H., Hankemeier, T., Bos, D., van der Lugt, A., Vernooij, M. W., Ikram, M. A., Amin, N., Barkhof, F., Teunissen, C. E., van Duijn, C. M., & van der Flier, W. M. (2020). Circulating metabolites are associated with brain atrophy and white matter hyperintensities. Alzheimer's and Dementia. https://doi.org/10.1002/alz.12180

de Leeuw, Francisca A. ; Karamujić-Čomić, Hata ; Tijms, Betty M. ; Peeters, Carel F. W. ; Kester, Maartje I. ; Scheltens, Philip ; Ahmad, Shahzad ; Vojinovic, Dina ; Adams, Hieab H. H. ; Hankemeier, Thomas ; Bos, Daniel ; van der Lugt, Aad ; Vernooij, Meike W. ; Ikram, M. Arfan ; Amin, Najaf ; Barkhof, Frederik ; Teunissen, Charlotte E. ; van Duijn, Cornelia M. ; van der Flier, Wiesje M. / Circulating metabolites are associated with brain atrophy and white matter hyperintensities. In: Alzheimer's and Dementia. 2020.

@article{e9fa25f6e78e41a9bc912a340f2e337c,

title = "Circulating metabolites are associated with brain atrophy and white matter hyperintensities",

abstract = "Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.",

keywords = "Alzheimer's disease, cholesterol, glucose, lipids, magnetic resonance imaging (MRI), metabolism",

author = "{de Leeuw}, {Francisca A.} and Hata Karamuji{\'c}-{\v C}omi{\'c} and Tijms, {Betty M.} and Peeters, {Carel F. W.} and Kester, {Maartje I.} and Philip Scheltens and Shahzad Ahmad and Dina Vojinovic and Adams, {Hieab H. H.} and Thomas Hankemeier and Daniel Bos and {van der Lugt}, Aad and Vernooij, {Meike W.} and Ikram, {M. Arfan} and Najaf Amin and Frederik Barkhof and Teunissen, {Charlotte E.} and {van Duijn}, {Cornelia M.} and {van der Flier}, {Wiesje M.}",

year = "2020",

doi = "10.1002/alz.12180",

language = "English",

journal = "Alzheimers & Dementia",

issn = "1552-5260",

publisher = "Elsevier",

}

de Leeuw, FA, Karamujić-Čomić, H, Tijms, BM , Peeters, CFW, Kester, MI, Scheltens, P, Ahmad, S, Vojinovic, D, Adams, HHH, Hankemeier, T, Bos, D, van der Lugt, A, Vernooij, MW, Ikram, MA, Amin, N, Barkhof, F , Teunissen, CE, van Duijn, CM & van der Flier, WM 2020, 'Circulating metabolites are associated with brain atrophy and white matter hyperintensities', Alzheimer's and Dementia. https://doi.org/10.1002/alz.12180

Circulating metabolites are associated with brain atrophy and white matter hyperintensities. / de Leeuw, Francisca A.; Karamujić-Čomić, Hata; Tijms, Betty M.; Peeters, Carel F. W.; Kester, Maartje I.; Scheltens, Philip; Ahmad, Shahzad; Vojinovic, Dina; Adams, Hieab H. H.; Hankemeier, Thomas; Bos, Daniel; van der Lugt, Aad; Vernooij, Meike W.; Ikram, M. Arfan; Amin, Najaf; Barkhof, Frederik ; Teunissen, Charlotte E.; van Duijn, Cornelia M.; van der Flier, Wiesje M.

In: Alzheimer's and Dementia, 2020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Circulating metabolites are associated with brain atrophy and white matter hyperintensities

AU - de Leeuw, Francisca A.

AU - Karamujić-Čomić, Hata

AU - Tijms, Betty M.

AU - Peeters, Carel F. W.

AU - Kester, Maartje I.

AU - Scheltens, Philip

AU - Ahmad, Shahzad

AU - Vojinovic, Dina

AU - Adams, Hieab H. H.

AU - Hankemeier, Thomas

AU - Bos, Daniel

AU - van der Lugt, Aad

AU - Vernooij, Meike W.

AU - Ikram, M. Arfan

AU - Amin, Najaf

AU - Barkhof, Frederik

AU - Teunissen, Charlotte E.

AU - van Duijn, Cornelia M.

AU - van der Flier, Wiesje M.

PY - 2020

Y1 - 2020

N2 - Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.

AB - Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.

KW - Alzheimer's disease

KW - cholesterol

KW - glucose

KW - lipids

KW - magnetic resonance imaging (MRI)

KW - metabolism

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85090236449&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/32886448

U2 - 10.1002/alz.12180

DO - 10.1002/alz.12180

M3 - Article

C2 - 32886448

JO - Alzheimers & Dementia

JF - Alzheimers & Dementia

SN - 1552-5260

ER -