Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies

Anne J. Wanders, Marjan Alssema, Sabine E. M. de Hoon, Edith J. M. Feskens, Geertruida J. van Woudenbergh, Carla J. van der Kallen, Peter L. Zock, Helga Refsum, Christian A. Drevon, Amany Elshorbagy, Casper G. Schalkwijk, Coen D. A. Stehouwer, Jacqueline M. Dekker, Marleen M. J. van Greevenbroek

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aims: To evaluate whether participant characteristics and way of expressing circulating fatty acids (FA) influence the strengths of associations between self-reported intake and circulating levels of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Methods: Cross-sectional analyses were performed in pooled data from the CODAM (n = 469) and Hoorn (n = 702) studies. Circulating FA were measured by gas liquid chromatography and expressed as proportions (% of total FA) and concentrations (μg/mL). Dietary intakes were calculated from a validated food frequency questionnaire. Effects of participant characteristics on associations between dietary and circulating FA were calculated using interaction analyses. Results: Standardized regression coefficients between dietary FA and proportions of circulating FA (% of total FA) were LA β = 0.28, ALA β = 0.13, EPA β = 0.34, and DHA β = 0.45. Body mass index (BMI), waist circumference, and presence of CVD influenced associations for LA; gender influenced LA, EPA, and DHA; alcohol intake influenced LA and DHA; and glucose tolerance status influenced ALA (p values interaction <0.05). Coefficients for circulating FA as concentrations were LA β = 0.19, ALA β = 0.10, EPA β = 0.31, and DHA β = 0.41. Conclusions: This study suggests that characteristics such as BMI, alcohol intake, and expressing circulating FA as proportions or concentrations, influence associations between dietary and circulating FA.
LanguageEnglish
Pages117-125
JournalAnnals of Nutrition and Metabolism
Volume72
Issue number2
DOIs
Publication statusPublished - 2018

Cite this

Wanders, A. J., Alssema, M., de Hoon, S. E. M., Feskens, E. J. M., van Woudenbergh, G. J., van der Kallen, C. J., ... van Greevenbroek, M. M. J. (2018). Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies. Annals of Nutrition and Metabolism, 72(2), 117-125. https://doi.org/10.1159/000486244
Wanders, Anne J. ; Alssema, Marjan ; de Hoon, Sabine E. M. ; Feskens, Edith J. M. ; van Woudenbergh, Geertruida J. ; van der Kallen, Carla J. ; Zock, Peter L. ; Refsum, Helga ; Drevon, Christian A. ; Elshorbagy, Amany ; Schalkwijk, Casper G. ; Stehouwer, Coen D. A. ; Dekker, Jacqueline M. ; van Greevenbroek, Marleen M. J. / Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies. In: Annals of Nutrition and Metabolism. 2018 ; Vol. 72, No. 2. pp. 117-125.
@article{5a0018a3151e4647b3f045b9d4019d1a,
title = "Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies",
abstract = "Aims: To evaluate whether participant characteristics and way of expressing circulating fatty acids (FA) influence the strengths of associations between self-reported intake and circulating levels of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Methods: Cross-sectional analyses were performed in pooled data from the CODAM (n = 469) and Hoorn (n = 702) studies. Circulating FA were measured by gas liquid chromatography and expressed as proportions ({\%} of total FA) and concentrations (μg/mL). Dietary intakes were calculated from a validated food frequency questionnaire. Effects of participant characteristics on associations between dietary and circulating FA were calculated using interaction analyses. Results: Standardized regression coefficients between dietary FA and proportions of circulating FA ({\%} of total FA) were LA β = 0.28, ALA β = 0.13, EPA β = 0.34, and DHA β = 0.45. Body mass index (BMI), waist circumference, and presence of CVD influenced associations for LA; gender influenced LA, EPA, and DHA; alcohol intake influenced LA and DHA; and glucose tolerance status influenced ALA (p values interaction <0.05). Coefficients for circulating FA as concentrations were LA β = 0.19, ALA β = 0.10, EPA β = 0.31, and DHA β = 0.41. Conclusions: This study suggests that characteristics such as BMI, alcohol intake, and expressing circulating FA as proportions or concentrations, influence associations between dietary and circulating FA.",
author = "Wanders, {Anne J.} and Marjan Alssema and {de Hoon}, {Sabine E. M.} and Feskens, {Edith J. M.} and {van Woudenbergh}, {Geertruida J.} and {van der Kallen}, {Carla J.} and Zock, {Peter L.} and Helga Refsum and Drevon, {Christian A.} and Amany Elshorbagy and Schalkwijk, {Casper G.} and Stehouwer, {Coen D. A.} and Dekker, {Jacqueline M.} and {van Greevenbroek}, {Marleen M. J.}",
year = "2018",
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Wanders, AJ, Alssema, M, de Hoon, SEM, Feskens, EJM, van Woudenbergh, GJ, van der Kallen, CJ, Zock, PL, Refsum, H, Drevon, CA, Elshorbagy, A, Schalkwijk, CG, Stehouwer, CDA, Dekker, JM & van Greevenbroek, MMJ 2018, 'Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies', Annals of Nutrition and Metabolism, vol. 72, no. 2, pp. 117-125. https://doi.org/10.1159/000486244

Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies. / Wanders, Anne J.; Alssema, Marjan; de Hoon, Sabine E. M.; Feskens, Edith J. M.; van Woudenbergh, Geertruida J.; van der Kallen, Carla J.; Zock, Peter L.; Refsum, Helga; Drevon, Christian A.; Elshorbagy, Amany; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Dekker, Jacqueline M.; van Greevenbroek, Marleen M. J.

In: Annals of Nutrition and Metabolism, Vol. 72, No. 2, 2018, p. 117-125.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies

AU - Wanders, Anne J.

AU - Alssema, Marjan

AU - de Hoon, Sabine E. M.

AU - Feskens, Edith J. M.

AU - van Woudenbergh, Geertruida J.

AU - van der Kallen, Carla J.

AU - Zock, Peter L.

AU - Refsum, Helga

AU - Drevon, Christian A.

AU - Elshorbagy, Amany

AU - Schalkwijk, Casper G.

AU - Stehouwer, Coen D. A.

AU - Dekker, Jacqueline M.

AU - van Greevenbroek, Marleen M. J.

PY - 2018

Y1 - 2018

N2 - Aims: To evaluate whether participant characteristics and way of expressing circulating fatty acids (FA) influence the strengths of associations between self-reported intake and circulating levels of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Methods: Cross-sectional analyses were performed in pooled data from the CODAM (n = 469) and Hoorn (n = 702) studies. Circulating FA were measured by gas liquid chromatography and expressed as proportions (% of total FA) and concentrations (μg/mL). Dietary intakes were calculated from a validated food frequency questionnaire. Effects of participant characteristics on associations between dietary and circulating FA were calculated using interaction analyses. Results: Standardized regression coefficients between dietary FA and proportions of circulating FA (% of total FA) were LA β = 0.28, ALA β = 0.13, EPA β = 0.34, and DHA β = 0.45. Body mass index (BMI), waist circumference, and presence of CVD influenced associations for LA; gender influenced LA, EPA, and DHA; alcohol intake influenced LA and DHA; and glucose tolerance status influenced ALA (p values interaction <0.05). Coefficients for circulating FA as concentrations were LA β = 0.19, ALA β = 0.10, EPA β = 0.31, and DHA β = 0.41. Conclusions: This study suggests that characteristics such as BMI, alcohol intake, and expressing circulating FA as proportions or concentrations, influence associations between dietary and circulating FA.

AB - Aims: To evaluate whether participant characteristics and way of expressing circulating fatty acids (FA) influence the strengths of associations between self-reported intake and circulating levels of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Methods: Cross-sectional analyses were performed in pooled data from the CODAM (n = 469) and Hoorn (n = 702) studies. Circulating FA were measured by gas liquid chromatography and expressed as proportions (% of total FA) and concentrations (μg/mL). Dietary intakes were calculated from a validated food frequency questionnaire. Effects of participant characteristics on associations between dietary and circulating FA were calculated using interaction analyses. Results: Standardized regression coefficients between dietary FA and proportions of circulating FA (% of total FA) were LA β = 0.28, ALA β = 0.13, EPA β = 0.34, and DHA β = 0.45. Body mass index (BMI), waist circumference, and presence of CVD influenced associations for LA; gender influenced LA, EPA, and DHA; alcohol intake influenced LA and DHA; and glucose tolerance status influenced ALA (p values interaction <0.05). Coefficients for circulating FA as concentrations were LA β = 0.19, ALA β = 0.10, EPA β = 0.31, and DHA β = 0.41. Conclusions: This study suggests that characteristics such as BMI, alcohol intake, and expressing circulating FA as proportions or concentrations, influence associations between dietary and circulating FA.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/29393106

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DO - 10.1159/000486244

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SP - 117

EP - 125

JO - Annals of Nutrition & Metabolism

T2 - Annals of Nutrition & Metabolism

JF - Annals of Nutrition & Metabolism

SN - 0250-6807

IS - 2

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