Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort

J.M. Rijkelijkhuizen, C.J. Girman, A. Mari, M.J. Alssema, T. Rhodes, M.G.A.A.M. Nijpels, P.J. Kostense, E.M.W. Eekhoff, P.P. Stein, R.J. Heine, J.M. Dekker

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Abstract

This study compared classical and model-based beta-cell responses during an oral glucose tolerance test (OGTT) and a meal tolerance test (MTT) in a population-based cohort. Individuals with normal glucose metabolism (NGM, n=161), impaired glucose metabolism (IGM, n=19) and type 2 diabetes mellitus (DM, n=20) underwent a 75 g-OGTT and an MTT (75 g carbohydrates, 50 g fat, 24 g proteins). Classical estimates of beta-cell function (insulinogenic index and the ratio of areas under insulin and glucose curves) were calculated. Mathematical modelling was used to determine beta-cell glucose sensitivity, rate sensitivity and potentiation. Insulin sensitivity was characterized by three surrogate estimates. Both classical and model-based estimates of beta-cell function were higher during MTT than during OGTT (P
Original languageUndefined/Unknown
Pages (from-to)280-288
JournalDiabetes Research and Clinical Practice
Volume83
Issue number2
DOIs
Publication statusPublished - 2009

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