Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients

Melek Simsek, Berrie Meijer, Dewkoemar Ramsoekh, Gerd Bouma, Egbert-Jan van der Wouden, Bert den Hartog, Annemarie C. de Vries, Frank Hoentjen, Gerard Dijkstra, Sybrand Y. de Boer, Jeroen M. Jansen, Andrea E. van der Meulen, Ruud Beukers, Menno A. Brink, Toos Steinhauser, Bas Oldenburg, Lennard P. Gilissen, Ton H. Naber, Marc A. Verhagen, Nanne K. H. de Boer & 2 others Chris J. J. Mulder, Dutch Initiative on Crohn and Colitis (ICC)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Nodular regenerative hyperplasia (NRH) is a poorly understood liver condition, which is increasingly recognized in thiopurine-treated patients with inflammatory bowel disease (IBD).1 It is difficult to establish an optimal approach to NRH patients, because its manifestations are highly variable (from asymptomatic to symptoms of noncirrhotic portal hypertension [NCPH]) and the prognosis is unknown.2 The aim of this study was to identify NRH cases in IBD patients treated with azathioprine, mercaptopurine, and/or thioguanine, and to describe its clinical course.

Original languageEnglish
Pages (from-to)568-570
Number of pages3
JournalClinical Gastroenterology and Hepatology
Volume17
Issue number3
Early online date2018
DOIs
Publication statusPublished - 1 Feb 2019

Cite this

Simsek, Melek ; Meijer, Berrie ; Ramsoekh, Dewkoemar ; Bouma, Gerd ; van der Wouden, Egbert-Jan ; den Hartog, Bert ; de Vries, Annemarie C. ; Hoentjen, Frank ; Dijkstra, Gerard ; de Boer, Sybrand Y. ; Jansen, Jeroen M. ; van der Meulen, Andrea E. ; Beukers, Ruud ; Brink, Menno A. ; Steinhauser, Toos ; Oldenburg, Bas ; Gilissen, Lennard P. ; Naber, Ton H. ; Verhagen, Marc A. ; de Boer, Nanne K. H. ; Mulder, Chris J. J. ; Dutch Initiative on Crohn and Colitis (ICC). / Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients. In: Clinical Gastroenterology and Hepatology. 2019 ; Vol. 17, No. 3. pp. 568-570.
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title = "Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients",
abstract = "Nodular regenerative hyperplasia (NRH) is a poorly understood liver condition, which is increasingly recognized in thiopurine-treated patients with inflammatory bowel disease (IBD).1 It is difficult to establish an optimal approach to NRH patients, because its manifestations are highly variable (from asymptomatic to symptoms of noncirrhotic portal hypertension [NCPH]) and the prognosis is unknown.2 The aim of this study was to identify NRH cases in IBD patients treated with azathioprine, mercaptopurine, and/or thioguanine, and to describe its clinical course.",
author = "Melek Simsek and Berrie Meijer and Dewkoemar Ramsoekh and Gerd Bouma and {van der Wouden}, Egbert-Jan and {den Hartog}, Bert and {de Vries}, {Annemarie C.} and Frank Hoentjen and Gerard Dijkstra and {de Boer}, {Sybrand Y.} and Jansen, {Jeroen M.} and {van der Meulen}, {Andrea E.} and Ruud Beukers and Brink, {Menno A.} and Toos Steinhauser and Bas Oldenburg and Gilissen, {Lennard P.} and Naber, {Ton H.} and Verhagen, {Marc A.} and {de Boer}, {Nanne K. H.} and Mulder, {Chris J. J.} and {Dutch Initiative on Crohn and Colitis (ICC)}",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.cgh.2018.05.009",
language = "English",
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journal = "Clinical Gastroenterology and Hepatology",
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Simsek, M, Meijer, B, Ramsoekh, D, Bouma, G, van der Wouden, E-J, den Hartog, B, de Vries, AC, Hoentjen, F, Dijkstra, G, de Boer, SY, Jansen, JM, van der Meulen, AE, Beukers, R, Brink, MA, Steinhauser, T, Oldenburg, B, Gilissen, LP, Naber, TH, Verhagen, MA, de Boer, NKH, Mulder, CJJ & Dutch Initiative on Crohn and Colitis (ICC) 2019, 'Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients' Clinical Gastroenterology and Hepatology, vol. 17, no. 3, pp. 568-570. https://doi.org/10.1016/j.cgh.2018.05.009

Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients. / Simsek, Melek; Meijer, Berrie; Ramsoekh, Dewkoemar; Bouma, Gerd; van der Wouden, Egbert-Jan; den Hartog, Bert; de Vries, Annemarie C.; Hoentjen, Frank; Dijkstra, Gerard; de Boer, Sybrand Y.; Jansen, Jeroen M.; van der Meulen, Andrea E.; Beukers, Ruud; Brink, Menno A.; Steinhauser, Toos; Oldenburg, Bas; Gilissen, Lennard P.; Naber, Ton H.; Verhagen, Marc A.; de Boer, Nanne K. H.; Mulder, Chris J. J.; Dutch Initiative on Crohn and Colitis (ICC).

In: Clinical Gastroenterology and Hepatology, Vol. 17, No. 3, 01.02.2019, p. 568-570.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients

AU - Simsek, Melek

AU - Meijer, Berrie

AU - Ramsoekh, Dewkoemar

AU - Bouma, Gerd

AU - van der Wouden, Egbert-Jan

AU - den Hartog, Bert

AU - de Vries, Annemarie C.

AU - Hoentjen, Frank

AU - Dijkstra, Gerard

AU - de Boer, Sybrand Y.

AU - Jansen, Jeroen M.

AU - van der Meulen, Andrea E.

AU - Beukers, Ruud

AU - Brink, Menno A.

AU - Steinhauser, Toos

AU - Oldenburg, Bas

AU - Gilissen, Lennard P.

AU - Naber, Ton H.

AU - Verhagen, Marc A.

AU - de Boer, Nanne K. H.

AU - Mulder, Chris J. J.

AU - Dutch Initiative on Crohn and Colitis (ICC)

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Nodular regenerative hyperplasia (NRH) is a poorly understood liver condition, which is increasingly recognized in thiopurine-treated patients with inflammatory bowel disease (IBD).1 It is difficult to establish an optimal approach to NRH patients, because its manifestations are highly variable (from asymptomatic to symptoms of noncirrhotic portal hypertension [NCPH]) and the prognosis is unknown.2 The aim of this study was to identify NRH cases in IBD patients treated with azathioprine, mercaptopurine, and/or thioguanine, and to describe its clinical course.

AB - Nodular regenerative hyperplasia (NRH) is a poorly understood liver condition, which is increasingly recognized in thiopurine-treated patients with inflammatory bowel disease (IBD).1 It is difficult to establish an optimal approach to NRH patients, because its manifestations are highly variable (from asymptomatic to symptoms of noncirrhotic portal hypertension [NCPH]) and the prognosis is unknown.2 The aim of this study was to identify NRH cases in IBD patients treated with azathioprine, mercaptopurine, and/or thioguanine, and to describe its clinical course.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/29775790

U2 - 10.1016/j.cgh.2018.05.009

DO - 10.1016/j.cgh.2018.05.009

M3 - Article

VL - 17

SP - 568

EP - 570

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 3

ER -