Clinical evidence on haemodiafiltration

Peter J. Blankestijn; Muriel P. Grooteman; Menso J. Nube; Michiel L. Bots

doi:10.1093/ndt/gfy218

Clinical evidence on haemodiafiltration

Peter J. Blankestijn^*, Muriel P. Grooteman, Menso J. Nube, Michiel L. Bots

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Haemodiafiltration (HDF) combines diffusive and convective solute removal in a single treatment session. HDF provides a greater removal of higher molecular weight uraemic retention solutes than conventional high-flux haemodialysis (HD). Recently completed randomized clinical trials suggest better patient survival with online HDF. The treatment is mainly used in Europe and Japan. This review gives a brief overview of the presently available evidence of the effects of HDF on clinical end points, it speculates on possible mechanisms of a beneficial effect of HDF as compared with standard HD and ends with some perspectives for the future.

Original language	English
Pages (from-to)	iii53-iii58
Journal	Nephrology Dialysis Transplantation
Volume	33
DOIs	https://doi.org/10.1093/ndt/gfy218
Publication status	Published - 1 Oct 2018

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10.1093/ndt/gfy218

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title = "Clinical evidence on haemodiafiltration",

abstract = "Haemodiafiltration (HDF) combines diffusive and convective solute removal in a single treatment session. HDF provides a greater removal of higher molecular weight uraemic retention solutes than conventional high-flux haemodialysis (HD). Recently completed randomized clinical trials suggest better patient survival with online HDF. The treatment is mainly used in Europe and Japan. This review gives a brief overview of the presently available evidence of the effects of HDF on clinical end points, it speculates on possible mechanisms of a beneficial effect of HDF as compared with standard HD and ends with some perspectives for the future.",

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author = "Blankestijn, {Peter J.} and Grooteman, {Muriel P.} and Nube, {Menso J.} and Bots, {Michiel L.}",

year = "2018",

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doi = "10.1093/ndt/gfy218",

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AU - Blankestijn, Peter J.

AU - Grooteman, Muriel P.

AU - Nube, Menso J.

AU - Bots, Michiel L.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Haemodiafiltration (HDF) combines diffusive and convective solute removal in a single treatment session. HDF provides a greater removal of higher molecular weight uraemic retention solutes than conventional high-flux haemodialysis (HD). Recently completed randomized clinical trials suggest better patient survival with online HDF. The treatment is mainly used in Europe and Japan. This review gives a brief overview of the presently available evidence of the effects of HDF on clinical end points, it speculates on possible mechanisms of a beneficial effect of HDF as compared with standard HD and ends with some perspectives for the future.

AB - Haemodiafiltration (HDF) combines diffusive and convective solute removal in a single treatment session. HDF provides a greater removal of higher molecular weight uraemic retention solutes than conventional high-flux haemodialysis (HD). Recently completed randomized clinical trials suggest better patient survival with online HDF. The treatment is mainly used in Europe and Japan. This review gives a brief overview of the presently available evidence of the effects of HDF on clinical end points, it speculates on possible mechanisms of a beneficial effect of HDF as compared with standard HD and ends with some perspectives for the future.

KW - chronic hemodialysis

KW - clinical outcome

KW - hemodiafiltration

KW - online hemodiafiltration

KW - review

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DO - 10.1093/ndt/gfy218

M3 - Article

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AN - SCOPUS:85054413147

SN - 0931-0509

VL - 33

SP - iii53-iii58

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

ER -

Clinical evidence on haemodiafiltration

Abstract

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