Clinical, immunological and virological response to different antiretroviral regimens in a cohort of HIV-2-infected patients

Marchina E. Van Der Ende*, Jan M. Prins, Kees Brinkman, Monique Keuter, Jan Veenstra, Sven A. Danner, Hubert G.M. Niesters, Albert D.M.E. Osterhaus, Martin Schutten

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To assess the clinical, immunological and virological response and the emergence of resistance towards antiretroviral therapy (ART) in a cohort of HIV-2-infected patients. Design: Observational study. Patients: HIV-2-infected patients residing in the Netherlands. Results: From 1995 to 2001 seven patients failed various ART regimens. The resistance mutations were analysed retrospectively. Development of mutations proved to be similar to that observed in HIV-1-infected patients, with the exception of a higher occurrence of the Q151M mutation within the reverse transcriptase gene. In a prospective study, comprising 13 consecutive naive HIV-2-infected patients, all patients achieved plasma HIV-2-RNA suppression below the detection limit (500 copies/ml). The antiretroviral regimen consisted of two nucleoside reverse transcriptase inhibitors (NRTIs) and indinavir, with a boosting dose of ritonavir; the median follow-up was 91 weeks. Two patients experienced a temporary virological rebound, while at the same time therapeutic drug monitoring showed sub-therapeutic plasma levels of indinavir. Conclusion: Sustained viral suppression in HIV-2-infected patients can be achieved using an antiretroviral regimen of two NRTIs and boosted indinavir or lopinavir.

Original languageEnglish
Pages (from-to)S55-S61
JournalAIDS
Volume17
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Jul 2003

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