TY - JOUR
T1 - Clinical superficial Raman probe aimed for epithelial tumor detection
T2 - Phantom model results
AU - Agenant, Michelle
AU - Grimbergen, Matthijs
AU - Draga, Ronald
AU - Marple, Eric
AU - Bosch, Ruud
AU - van Swol, Christiaan
PY - 2014/4/1
Y1 - 2014/4/1
N2 - A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a nonsuperficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of a polyethylene terephthalate disc in an 20%-Intralipid® solution. Sampling ranges of 0-200 and 0-300 μm were obtained for the superficial and non-superficial probe, respectively. The mean signal-to-noise ratio of the superficial probe increased by a factor of 2 compared with the non-superficial probe. This newly developed superficial Raman probe is expected to improve epithelial cancer detection in vivo.
AB - A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a nonsuperficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of a polyethylene terephthalate disc in an 20%-Intralipid® solution. Sampling ranges of 0-200 and 0-300 μm were obtained for the superficial and non-superficial probe, respectively. The mean signal-to-noise ratio of the superficial probe increased by a factor of 2 compared with the non-superficial probe. This newly developed superficial Raman probe is expected to improve epithelial cancer detection in vivo.
UR - http://www.scopus.com/inward/record.url?scp=84896918965&partnerID=8YFLogxK
U2 - 10.1364/BOE.5.001203
DO - 10.1364/BOE.5.001203
M3 - Article
AN - SCOPUS:84896918965
VL - 5
SP - 1203
EP - 1216
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 4
ER -