Clinical superficial Raman probe aimed for epithelial tumor detection: Phantom model results

Michelle Agenant*, Matthijs Grimbergen, Ronald Draga, Eric Marple, Ruud Bosch, Christiaan van Swol

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a nonsuperficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of a polyethylene terephthalate disc in an 20%-Intralipid® solution. Sampling ranges of 0-200 and 0-300 μm were obtained for the superficial and non-superficial probe, respectively. The mean signal-to-noise ratio of the superficial probe increased by a factor of 2 compared with the non-superficial probe. This newly developed superficial Raman probe is expected to improve epithelial cancer detection in vivo.

Original languageEnglish
Pages (from-to)1203-1216
Number of pages14
JournalBiomedical Optics Express
Issue number4
Publication statusPublished - 1 Apr 2014

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